Kroemer, Guido


Kroemer, Guido - Oncoimmunology, ebook


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Table of contents

1. Principles of Oncoimmunology
Laurence Zitvogel, Guido Kroemer

Part I. Fundamentals in I-O

2. The Human Tumor Microenvironment
Yann Vano, Nicolas A. Giraldo, Wolf Herman Fridman, Catherine Sautès-Fridman

3. CD8+ T Cells in Immunotherapy, Radiotherapy, and Chemotherapy
Weimin Wang, Michael Green, J. Rebecca Liu, Theodore S. Lawrence, Weiping Zou

4. Mutant Epitopes in Cancer
Martin Rao, Liu Zhenjiang, Qingda Meng, Georges Sinclair, Ernest Dodoo, Markus Maeurer

5. The Secrets of T Cell Polarization
Thaiz Rivera Vargas, Lionel Apetoh

6. Regulatory T Cells: Their Role, Mechanism of Action, and Impact on Cancer
Anthony R. Cillo, Dario A. A. Vignali

7. Purinergic Receptors: Novel Targets for Cancer Immunotherapy
Dipti Vijayan, Mark J. Smyth, Michele W. L. Teng

8. Plasmacytoid DC/Regulatory T Cell Interactions at the Center of an Immunosuppressive Network in Breast and Ovarian Tumors
N. Bendriss-Vermare, N. Gourdin, N. Vey, J. Faget, V. Sisirak, I. Labidi-Galy, I. Mercier, N. Goutagny, I. Puisieux, C. Ménétrier-Caux, C. Caux

9. Cancer Immunosurveillance by Natural Killer Cells and Other Innate Lymphoid Cells
Camille Guillerey, Mark J. Smyth

10. Biology of Myeloid-Derived Suppressor Cells
Kevin Alicea-Torres, Dmitry I. Gabrilovich

11. Effect of Pharmaceutical Compounds on Myeloid-Derived Suppressor Cells
Mélanie Bruchard, Francois Ghiringhelli

12. Immunogenic Stress and Death of Cancer Cells in Natural and Therapy-Induced Immunosurveillance
Oliver Kepp, Jonathan Pol, Laurence Zitvogel, Guido Kroemer

13. Genetics and Immunology: Tumor-Specific Genetic Alterations as a Target for Immune Modulating Therapies
Anna S. Berghoff, Jakob Nikolas Kather, Dirk Jäger

Part II. Breakthrough Status

14. Peptide-Based Therapeutic Cancer Vaccines
Cornelis J. M. Melief

15. Cancer Vaccines for HPV Malignancies
Maria Agarwal, Cornelia Trimble

16. NK Cell-Based Therapies
Laura Chiossone, Eric Vivier

17. IDO/TDO Inhibition in Cancer
George C. Prendergast, William J. Malachowski, Arpita Mondal, Peggy Scherle, Alexander J. Muller

Part III. FDA-EMA Approval of I-O

18. Tumor-Targeted Antibodies
Aurélien Marabelle

19. PD1 Checkpoint Blockade in Melanoma: From Monotherapy to Combination Therapies
Annette Paschen, Dirk Schadendorf

20. Immune Checkpoint Inhibition in Lung Cancer
Daniel Morgensztern, Roy S. Herbst

21. PD-1 Blockade in Renal Cell Carcinoma
Lisa Derosa, Bernard Escudier

22. BCG and Anti-PDL-1 Ab in Bladder Cancers
Pernelle Lavaud, Yohann Loriot

23. PD-L1 and Other Immunological Diagnosis Tools
Nicolas A. Giraldo, Janis M. Taube

24. Oncolytic Viruses: T-VEC and Others
Rutika Mehta, Igor Puzanov

Part IV. Developing Fields

25. Innate Immune Receptors in the Regulation of Tumor Immunity
Sho Hangai, Yoshitaka Kimura, Tadatsugu Taniguchi, Hideyuki Yanai

26. Co-stimulation Agonists via CD137, OX40, GITR, and CD27 for Immunotherapy of Cancer
Ignacio Melero, Elisabeth Pérez-Ruiz, Alfonso R. Sanchez-Paulete, Alvaro Teijeira, Angela Aznar, Miguel F. Sanmamed

27. The Impact of the Intestinal Microbiota in Therapeutic Responses Against Cancer
Mélodie Bonvalet, Romain Daillère, Maria P. Roberti, Conrad Rauber, Laurence Zitvogel

28. Local Immunotherapies of Cancer
Thomas U. Marron, Linda Hammerich, Joshua Brody

29. Strategies to Reduce Intratumoral Regulatory T Cells
C. Maherzi, F. Onodi, E. Tartour, M. Terme, C. Tanchot

30. Synergy Between Radiotherapy and Immunotherapy
Sandra Demaria, Sophia Bornstein, Silvia C. Formenti

31. Predictors of Response to Immune Checkpoint Blockade
Miles C. Andrews, Jennifer A. Wargo

Part V. Changes in Clinical Practice

32. Immune Therapies in Phase 1 Trials
Sophie Postel-Vinay, Jean-Charles Soria

33. Side Effects of Cancer Immunotherapy with Checkpoint Inhibitors
Lucia Festino, Paolo A. Ascierto

34. Melanoma: Immunotherapy in Advanced Melanoma and in the Adjuvant Setting
Alexander M. M. Eggermont, Caroline Robert

35. Immunotherapy for Prostate Cancer: An Evolving Landscape
Wendy Mao, Charles G. Drake

36. Challenges of Oncoimmunology for Ovarian and Breast Cancers
Mathilde Saint-Ghislain, Marie Bretagne, Marie-Paule Sablin, Emanuela Romano

37. Challenges in Colorectal Cancer: From Vaccines to Macrophage Repolarization
Niels Halama

38. Current Status of Immuno-Oncology in Hematologic Cancers
Bertrand Routy, David Ghez

39. Immunotherapy of Gliomas
Michael Platten

40. Assessing T Cell Receptor Affinity and Avidity Against Tumor Antigens
Mathilde Allard, Michael Hebeisen, Nathalie Rufer

41. Immune Monitoring of Blood and Tumor Microenvironment
Petra Baumgaertner, Kalliopi Ioannidou, Daniel E. Speiser

42. Toward Engineered Cells as Transformational and Broadly Available Medicines for the Treatment of Cancer
Cedrik M. Britten, Laura A. Johnson, Alfonso Quintás-Cardama, Neil C. Sheppard, Axel Hoos

Part VI. Concluding Remarks

43. Concluding Remarks
Pedro Romero, Wolf H. Fridman

Keywords: Medicine & Public Health, Oncology, Immunology, Cancer Research

Publication year
Page amount
10 pages
Medicine, Health Care, Mode
Printed ISBN

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