Heart Failure

1. The Three-Decade Long Journey in Heart Failure Drug Development
Kelly S. Lewis, Javed Butler, Johann Bauersachs, Peter Sandner

2. Epidemiology of Heart Failure
Francesco Orso, Gianna Fabbri, Aldo Pietro Maggioni

3. Comorbidities in Heart Failure
Haye H. Wal, Vincent M. Deursen, Peter Meer, Adriaan A. Voors

4. Clinical Trial Design, Endpoints, and Regulatory Requirements
Giuseppe M. C. Rosano

5. Biomarkers of Heart Failure with Preserved and Reduced Ejection Fraction
Michele Senni, Emilia D’Elia, Michele Emdin, Giuseppe Vergaro

6. Heart Failure Guidelines on Pharmacotherapy
Lampros Papadimitriou, Carine E. Hamo, Javed Butler

7. Sacubitril/Valsartan (LCZ696) in Heart Failure
Yasser Khder, Victor Shi, John J. V. McMurray, Martin P. Lefkowitz

8. Ivabradine
Michel Komajda

9. Partial Adenosine A1 Agonist in Heart Failure
Wilfried Dinh, Barbara Albrecht-Küpper, Mihai Gheorghiade, Adriaan A. Voors, Michael Laan, Hani N. Sabbah

10. New and Emerging Therapies and Targets: Beta-3 Agonists
Lauriane Y. M. Michel, Jean-Luc Balligand

11. Novel sGC Stimulators and sGC Activators for the Treatment of Heart Failure
Stefanie Breitenstein, Lothar Roessig, Peter Sandner, Kelly S. Lewis

12. Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease
Grace E. Kim, David A. Kass

13. Steroidal and Novel Non-steroidal Mineralocorticoid Receptor Antagonists in Heart Failure and Cardiorenal Diseases: Comparison at Bench and Bedside
Peter Kolkhof, Frederic Jaisser, So-Young Kim, Gerasimos Filippatos, Christina Nowack, Bertram Pitt

14. Vasopressin and Vasopressin Antagonists in Heart Failure
Julie K. Vishram-Nielsen, Finn Gustafsson

15. Mesenchymal Stem Cell Therapy for the Treatment of Heart Failure Caused by Ischemic or Non-ischemic Cardiomyopathy: Immunosuppression and Its Implications
Michael J. Lipinski, Dror Luger, Stephen E. Epstein

16. Platelet-Derived Growth Factor in Heart Failure
John Medamana, Richard A. Clark, Javed Butler

17. Wnt Signaling in Cardiac Remodeling and Heart Failure
Vasili Stylianidis, Kevin C. M. Hermans, W. Matthijs Blankesteijn

18. Gene Therapy in Heart Failure
Anthony S. Fargnoli, Michael G. Katz, Charles R. Bridges, Roger J. Hajjar

19. Noncoding RNAs in Heart Failure
Seema Dangwal, Katharina Schimmel, Ariana Foinquinos, Ke Xiao, Thomas Thum

20. Cardiac Myosin Activation with Gene Therapy Produces Sustained Inotropic Effects and May Treat Heart Failure with Reduced Ejection Fraction
Sam L. Teichman, Kassandra S. Thomson, Michael Regnier

21. Direct Myosin Activation by Omecamtiv Mecarbil for Heart Failure with Reduced Ejection Fraction
Mitchell A. Psotka, John R. Teerlink

22. Mitochondrial Therapies in Heart Failure
Albrecht Hardenberg, Christoph Maack

23. Anticoagulation Therapy and NOACs in Heart Failure
Isac Thomas, Jorge EncisoSilva, Michelle Schlueter, Barry Greenberg

24. Role of Hyperkalemia in Heart Failure and the Therapeutic Use of Potassium Binders
Chaudhry M. S. Sarwar, Aditi A. Bhagat, Stefan D. Anker, Javed Butler

25. Iron Deficiency Treatment in Patients with Heart Failure
Ewa A. Jankowska, Marcin Drozd, Piotr Ponikowski

Keywords: Biomedicine, Pharmacology/Toxicology, Cardiology, Human Physiology