Science of Ashwagandha: Preventive and Therapeutic Potentials

Part I. Ashwagandha – Phytogenomics and Pharmacology

1. Phytochemical Genomics of Ashwagandha
Neelam S. Sangwan, Sandhya Tripathi, Yashdeep Srivastava, Bhawana Mishra, Neha Pandey

2. Phytopharmacology of Ashwagandha as an Anti-Diabetic Herb
Vikas Kumar, Amitabha Dey, Shyam Sunder Chatterjee

3.
Allium cepa Root Chromosomal Aberration Assay: An Application in Assessing Anti-genotoxic Potential of Ashwagandha
Rajneet Kour Soodan, Ashita Sharma, Mandeep Kaur, Jatinder Kaur Katnoria, Avinash Kaur Nagpal

4.
Withania somnifera: From Traditional Use to Evidence Based Medicinal Prominence
Sheikh Rayees, Fayaz Malik

5. Withanolides: A Prospective Drug for Infectious and Tropical Diseases
Radheshyam Maurya

6.
Withania somnifera Extract/Withaferin A as a Prospective Anti-pigmenting Agent
Genji Imokawa

Part II. Ashwagandha for Cancer

7. Ashwagandha Bioactives for Cancer Treatment: Experimental Evidence and Their Mechanism(s) of Action
Renu Wadhwa, Sukant Garg, Ashish Kaul, Sunil C. Kaul

8. Scientific Evidence for Anticancer Effects of Withania somnifera and Its Primary Bioactive Component Withaferin A
Anuradha Sehrawat, Suman K. Samanta, Su-Hyeong Kim, Eun-Ryeong Hahm, Shivendra V. Singh

9. Withaferin-A as a Potential Candidate for Cancer Therapy: Experimental Evidence of Its Effects on Telomerase Plus and Minus Cancer Cells
Zeenia Kaul, Yue Yu, Sunil C. Kaul, Renu Wadhwa

10.
Withania somnifera Has Potential to Treat Cancer
Babli Halder, Suman S. Thakur

11. The Effects of Withaferin A on Normal and Malignant Immune Cells
Sara S. Alhakeem, Mary K. McKenna, Karine Z. Oben, Beth W. Gachuki, Sunil K. Noothi, Natarajan Muthusamy, Vivek M. Rangnekar, Ramesh C. Gupta, Subbarao Bondada

12. Ashwagandha for Cancer Metastasis: Bioactives and Basics of Their Function
Sunil C. Kaul, Priyanshu Bhargava, Renu Wadhwa

13. Computational Methods to Understand the Anticancer Mechanism of Withanolides
Shashank P. Katiyar, Vidhi Malik, Anjani Kumari, Durai Sundar

Part III. Ashwagandha for Brain

14. Ashwagandha for Brain Health: Experimental Evidence for Its Neuroregenerative Activities
Renu Wadhwa, Rajkumar S. Kalra, Anupama Chaudhary, Sunil C. Kaul

15. Cellular and Molecular Targets Underpinning Memory Enhancement by Ashwagandha
Arpita Konar, Mahendra K. Thakur

16. Using Human Neural Stem Cells as a Model to Understand the “Science of Ashwagandha”
Manju Tewari, Hriday S. Pandey, Pankaj Seth

17. The Potential Utility of Ashwagandha for Improving Cognitive Dysfunction in Persons with Bipolar or Other Neurocognitive Disorders
K. N. Roy Chengappa, Jessica M. Gannon, Luna Acharya, Abhishek Rai

18. Neuroprotective Potential of Withania somnifera (Ashwagandha) in Neurological Conditions
Rajat Sandhir, Abhilasha Sood

19. Potential Therapeutic Use of Withania somnifera for Treatment of Amyotrophic Lateral Sclerosis
Kallol Dutta, Vivek Swarup, Jean-Pierre Julien

20. Neuromodulatory Role of Withania somnifera

Gurcharan Kaur, Taranjeet Kaur, Muskan Gupta, Shaffi Manchanda

21. Therapeutic Effects of Ashwagandha in Brain Aging and Clock Dysfunction
Anita Jagota, K. Kowshik

Part IV. Active Ingredient Enriched Ashwagandha – Biotechnologies

22. Biotechnological Approaches in Propagation and Improvement of Withania somnifera (L.) Dunal
Kulwinder Kaur, Pritika Singh, Rupam Guleri, Baldev Singh, Kuldeep Kaur, Varinder Singh, Pratap Kumar Pati

23. Plant Tissue Culture Based Strategies for Production of Withanolides
Deepika Soni, Preeti Rana, Sukriti Goyal, Aditi Singh, Salma Jamal, Abhinav Grover

24. Establishment of Hydroponic Cultivation of Ashwagandha for Active Ingredient Enriched Leaves
Sunil C. Kaul, Sukant Garg, Kazuya Tamura, Teruo Wada, Zeenia Kaul, Renu Wadhwa

Keywords: Biomedicine, Biomedicine general, Health Promotion and Disease Prevention, Popular Science in Medicine and Health, Medical Education, Complementary & Alternative Medicine