Phosphodiesterases: CNS Functions and Diseases

Part I. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders

1. Phosphodiesterase Diversity and Signal Processing Within cAMP Signaling Networks
Susana R. Neves-Zaph

2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry
Jan-Philip Schülke, Nicholas J. Brandon

3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases
Yafang Hu, Suyue Pan, Han-Ting Zhang

4. The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action
Graeme B. Bolger

5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-Related Metabolic Diseases
Steven J. Clapcote

Part II. PDEs in Cognition of Aging and Alzheimer’s Disease

6. From Age-Related Cognitive Decline to Alzheimer’s Disease: A Translational Overview of the Potential Role for Phosphodiesterases
Pim R. A. Heckman, Arjan Blokland, Jos Prickaerts

7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for Age-Induced Memory Loss
Rolf T. Hansen, Han-Ting Zhang

8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood
Michy P. Kelly

9. Role of PDE9 in Cognition
C. Dorner-Ciossek, K. S. Kroker, H. Rosenbrock

Part III. PDEs in Parkinson’s and Huntington’s Diseases

10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson’s Disease
Fernando E. Padovan-Neto, Anthony R. West

11. Role of Phosphodiesterases in Huntington’s Disease
Francesca R. Fusco, Emanuela Paldino

Part IV. PDEs and Psychiatric Disorders

12. The Role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders
Chong Zhang, Lindsay M. Lueptow, Han-Ting Zhang, James M. O’Donnell, Ying Xu

13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction
Lawrence P. Wennogle, Helen Hoxie, Youyi Peng, Joseph P. Hendrick

14. PDE Inhibitors for the Treatment of Schizophrenia
Gretchen L. Snyder, Kimberly E. Vanover

Part V. PDEs and Others

15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence
Rui-Ting Wen, Jian-Hui Liang, Han-Ting Zhang

16. Genetic Understanding of Stroke Treatment: Potential Role for Phosphodiesterase Inhibitors
Anjana Munshi, Satrupa Das

17. A Unique Sub-Pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS
Yousheng Wang, Hengming Ke

Keywords: Biomedicine, Neurosciences