Centromeres and Kinetochores

Part I. Identification, Organization, and Regulation of Centromere and Kinetochore Components

1. Use of Mass Spectrometry to Study the Centromere and Kinetochore
Itaru Samejima, Melpomeni Platani, William C. Earnshaw

2. Critical Foundation of the Kinetochore: The Constitutive Centromere-Associated Network (CCAN)
Masatoshi Hara, Tatsuo Fukagawa

3. The Power of Xenopus Egg Extract for Reconstitution of Centromere and Kinetochore Function
Bradley T French, Aaron F Straight

4. Centrochromatin of Fungi
Steven Friedman, Michael Freitag

5. Evolutionary Lessons from Species with Unique Kinetochores
Ines A. Drinnenberg, Bungo Akiyoshi

6. Quantitative Microscopy Reveals Centromeric Chromatin Stability, Size, and Cell Cycle Mechanisms to Maintain Centromere Homeostasis
Ana Stankovic, Lars E. T. Jansen

Part II. Epigenetic Contributions to Centromere Identity and Function

7. Orchestrating the Specific Assembly of Centromeric Nucleosomes
Ewelina Zasadzińska, Daniel R. Foltz

8. Artificial Chromosomes and Strategies to Initiate Epigenetic Centromere Establishment
Evelyne J. Barrey, Patrick Heun

9. Post-translational Modifications of Centromeric Chromatin
Ana García del Arco, Sylvia Erhardt

10. Centromere Silencing Mechanisms
Shannon M. McNulty, Beth A. Sullivan

11. Centromere Transcription: Means and Motive

Zachary Duda, Sarah Trusiak, Rachel O’Neill

Part III. The Role of DNA Sequence in Centromere Identity and Function

12. The Promises and Challenges of Genomic Studies of Human Centromeres
Karen H. Miga

13. DNA Sequences in Centromere Formation and Function
M. Dumont, D. Fachinetti

14. The Unique DNA Sequences Underlying Equine Centromeres
Elena Giulotto, Elena Raimondi, Kevin F. Sullivan

Part IV. The Functions and Mechanisms of Centromeres and Kinetochores in Healthy Meiotic and Mitotic Divisions and their Role in Human Disease

15. Centromere Dynamics in Male and Female Germ Cells
Elaine M. Dunleavy, Caitríona M. Collins

16. Cell Biology of Cheating—Transmission of Centromeres and Other Selfish Elements Through Asymmetric Meiosis
Lukáš Chmátal, Richard M. Schultz, Ben E. Black, Michael A. Lampson

17. Biophysics of Microtubule End Coupling at the Kinetochore
Ekaterina L. Grishchuk

18. Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing
Kevin D Corbett

19. A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC
Giulia Vallardi, Marilia Henriques Cordeiro, Adrian Thomas Saurin

20. Centromeric Cohesin: Molecular Glue and Much More
Mihailo Mirkovic, Raquel A. Oliveira

21. Centromere Structure and Function
Kerry Bloom, Vincenzo Costanzo

22. The Role of Centromere Defects in Cancer
Thian Thian Beh, Paul Kalitsis

Keywords: Life Sciences, Cell Cycle Analysis, Cell Physiology, Human Genetics