Graier, Wolfgang F.

Store-Operated Ca²⁺ Entry (SOCE) Pathways

Graier, Wolfgang F. - Store-Operated Ca²⁺ Entry (SOCE) Pathways, ebook


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Table of contents

Part I. SOCE: Fundamental Mechanistic Concepts

1. Introduction
James W. Putney

2. The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex
Jinhui Zhu, Qingping Feng, Peter B. Stathopulos

3. The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel
Aparna Gudlur, Patrick G. Hogan

4. The STIM-Orai Pathway: The Interactions Between STIM and Orai
Marc Fahrner, Rainer Schindl, Martin Muik, Isabella Derler, Christoph Romanin

5. The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry
Robert M. Nwokonko, Xiangyu Cai, Natalia A. Loktionova, Youjun Wang, Yandong Zhou, Donald L. Gill

6. The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications
Barbara A. Niemeyer

7. The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels
Guolin Ma, Shufan Wen, Yun Huang, Yubin Zhou

8. STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes
Dora Bodnar, Woo Young Chung, Dongki Yang, Jeong Hee Hong, Archana Jha, Shmuel Muallem

9. STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function
Hwei Ling Ong, Indu S. Ambudkar

10. STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex
Jonathan Pacheco, Luis Vaca

Part II. SOCE: Crosstalk Between Organelle and Cellular Compartments

11. Introduction
Alexei V. Tepikin

12. New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE
Hayley Dingsdale, Emmanuel Okeke, Lee Haynes, Gyorgy Lur, Alexei V. Tepikin

13. New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores
Alexis Bavencoffe, Michael Xi Zhu, Jin-bin Tian

14. The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and Mitochondria
András Spät, Gergö Szanda

15. The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling Hubs Sustaining Store-Operated Ca2+ Entry
Nicolas Demaurex, Daniele Guido

16. The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry
Roland Malli, Wolfgang F. Graier

17. Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling
Nicola Fameli, A. Mark Evans, Cornelis Breemen

18. Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells
Lothar A. Blatter

19. Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes
Martin D. Bootman, Katja Rietdorf

Part III. SOCE: Molecular and Cellular (Patho)Physiology

20. Introduction: Overview of the Pathophysiological Implications of Store-Operated Calcium Entry in Mammalian Cells
Juan A. Rosado

21. Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes
Sonal Srikanth, Jin Seok Woo, Zuoming Sun, Yousang Gwack

22. Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders
Jyoti Tanwar, Mohamed Trebak, Rajender K. Motiani

23. Cardiovascular and Hemostatic Disorders: SOCE and Ca2+ Handling in Platelet Dysfunction
Jose J. Lopez, Gines M. Salido, Juan A. Rosado

24. Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention
Klaus Groschner, Niroj Shrestha, Nicola Fameli

25. Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology
Petra Eder

26. Cardiac Remodeling and Disease: Current Understanding of STIM1/Orai1-Mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology
Fiona Bartoli, Jessica Sabourin

27. Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function
Sunitha Bollimuntha, Biswaranjan Pani, Brij B. Singh

28. Neurological and Motor Disorders: TRPC in the Skeletal Muscle
Sophie Saüc, Maud Frieden

29. Fertility: Store-Operated Ca2+ Entry in Germ Cells: Role in Egg Activation
Zoltan Machaty, Chunmin Wang, Kiho Lee, Lu Zhang

30. Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease
Eunüs S. Ali, Grigori Y. Rychkov, Greg J. Barritt

31. Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion
Abigaël Ritaine, George Shapovalov, Natalia Prevarskaya

Keywords: Life Sciences, Cell Biology, Medical Biochemistry, Biological and Medical Physics, Biophysics, Cardiology

Publication year
2nd ed. 2017
Advances in Experimental Medicine and Biology
Page amount
29 pages
Natural Sciences
Printed ISBN

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