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Eskes, Chantra

Alternatives for Dermal Toxicity Testing

Eskes, Chantra - Alternatives for Dermal Toxicity Testing, ebook

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ISBN: 9783319503530
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Table of contents

Part I. Skin Irritation

1. Overview on Current Status of Alternative Methods and Testing Approaches for Skin Irritation Testing
Chantra Eskes, Markus Hofmann

2. Skin Irritation Hazard of Chemicals Assessed by the EpiSkin™ In Vitro Test Method
Nathalie Alépée, Marie Hélène Grandidier, José Cotovio

3. The EpiDerm™ Skin Irritation Test (EpiDerm™ SIT)
Helena Kandarova, Manfred Liebsch

4. An In Vitro Skin Irritation Test Using the SkinEthic™ Reconstructed Human Epidermal (RHE) Model
Nathalie Alépée, Marie Hélène Grandidier, Carine Tornier, José Cotovio

5.
In Vitro Skin Irritation Assay with the LabCyte EPI-MODEL
Hajime Kojima, Masakazu Katoh

6. The epiCS® Skin Irritation Test (SIT) Method
Oliver Engelking, Horst W. Fuchs, Dirk Weisensee

Part II. Skin Corrosion

7. Overview on Current Status of Alternative Methods and Testing Approaches for Skin Corrosion Testing
Chantra Eskes, Markus Hofmann

8. The EpiSkin™ Human Epidermis Model for In Vitro Skin Corrosion of Test Chemicals
Nathalie Alépée, Marie Hélène Grandidier, José Cotovio

9. The EpiDerm™ Skin Corrosion Test (EpiDerm™ SCT)
Helena Kandarova, Manfred Liebsch

10. Assessment of the Human Epidermis SkinEthic™ RHE Model for In Vitro Skin Corrosion Testing of Chemicals
Nathalie Alépée, Marie-Hélène Grandidier, José Cotovio

11. The epiCS® Skin Corrosion Test Method
Oliver Engelking, Dirk Weisensee, Horst W. Fuchs

12. The In Vitro Membrane Barrier Test Corrositex® for Skin Corrosion
Rich Ulmer, Amy Wang

13. The Rat Skin Transcutaneous Electrical Resistance (TER) Test
Robert Guest

Part III. Skin Sensitization

14. Overview on Current Status and Combination of Test Methods
Erwin L. Roggen

15. The Local Lymph Node Assay
David A. Basketter, Ian Kimber, G. Frank Gerberick

16. Utilization of Peptide Reactivity Assays for the Prediction of Skin Sensitization
G. Frank Gerberick, John A. Troutman, Leslie M. Foertsch, Petra S. Kern

17. The KeratinoSens™ Assay for Skin Sensitization Screening
Andreas Natch

18. LuSens: Shedding Light on Skin Sensitization
Tzutzuy Ramirez, Annette Mehling, Robert Landsiedel

19. NCTC 2544 and IL-18 Production: A Tool for the Identification of Contact Allergens
Emanuela Corsini, Valentina Galbiati

20. Epidermal Equivalent (EE) Potency Assay
Susan Gibbs, Sander W. Spiekstra

21. The h-CLAT Method
Hitoshi Sakaguchi, Takao Ashikaga

22. U-SENS™: A U937 Cell Line Activation Test for Skin Sensitization
Nathalie Alépée, Cécile Piroird, Laurent Nardelli

23. Human Peripheral Blood Monocyte Derived Dendritic Cells Assay for the Detection and Characterization of Sensitizers
Andreas Schepky, Hendrik Reuter, Jochen Kühnl, Pierre Aeby

24. VITOSENS™
Nathalie Lambrechts, Greet Schoeters, Rosette Heuvel, Hilda Witters, Inge Nelissen, Jef Hooyberghs

25. The SENS-IS Assay
Françoise Cottrez, Elodie Boitel, Claude Auriault, Hervé Groux

26. The SenCeeTox® Assay
Donald Keller, Caroline Bauch, Prakash Patel

27. GARD: Genomic Allergen Rapid Detection
Malin Lindstedt, Kathrin Stephanie Zeller, Henrik Johansson, Carl Borrebaeck

28. Proteomics Testing for Sensitization Potency Using the Sensiderm™ TMT-SRM 10-Plex Assay
Petra Budde, Hans-Dieter Zucht, Ian Pike

29.
In Vitro Dendritic Cell-Based Test for Skin Sensitizers Identification and Potency Estimation
Bruno Miguel Neves, João Demétrio Martins, Isabel Ferreira, Ana Silva, Maria Teresa Cruz

30. An In Vitro Human Skin Test for Assessing Adverse Immune Reactions and Sensitization Potential
Anne Dickinson, Xiao Nong Wang, Shaheda Ahmed

31. The Human T Cell Priming Assay (hTCPA)
Philipp R. Esser, Stefan F. Martin

32. Promising Test Systems Beyond the Current Status
Erwin L. Roggen

Part IV. UV-Induced Effects (Phototoxicity and Photoallergy)

33. Overview on the Current Status of Available Test Methods and Additional Promising Methods for Assessing UV-Induced Effects
Lorena Rigo Gaspar, Camila Martins Kawakami, Carolina Gomes Benevenuto

34. Reactive Oxygen Species Assay for Evaluating Phototoxicity Potential
Hajime Kojima, Kazuhiro Hosoi, Satomi Onoue

35. The EpiDerm™ Phototoxicity Test (EpiDerm™ H3D-PT)
Helena Kandarova, Manfred Liebsch

Part V. Skin Genotoxicity

36. Overview on Current Status
Stefan Pfuhler, Kerstin Reisinger

37. Reconstructed Skin Micronucleus Assay (RSMN)
Stefan Pfuhler, Kerstin Reisinger

38. 3D Skin Comet Assay
Kerstin Reisinger, Stefan Pfuhler

39. Role in a Testing Strategy
Kerstin Reisinger, Stefan Pfuhler

Part VI. Other Exploratory Areas of Relevance

40. Progenitor Skin Cell Therapy and Evolution of Medical Applications
Lee Ann Applegate, Paris Jafari, Corinne Scaletta, Anthony Buys Roessingh, Wassim Raffoul, Nathalie Hirt-Burri

41. Integrated Safety Strategy for the Development of Children’s Cosmetic Products Using In Vitro and Clinical Methodologies
Andrezza di Pietro Micali Canavez, Talita M. T. P. Silveira, Natalia de Albuquerque Vita, Ana Cristina Weihermann, Caroline Radoski Neumann, Desirée Cigaran Schuck, Marcela Contador Baptista, Odivania Kruger, Carla Abdo Brohem, Marcio Lorencini

42. High-Throughput Screening Techniques
Rico Brendtke, Bart Wever, Florian Groeber, Jan Hansmann, Freia Schmid, Heike Walles

Keywords: Medicine & Public Health, Dermatology, Pharmacology/Toxicology, Animal Models

Editor
 
 
Publisher
Springer
Publication year
2017
Language
en
Edition
1
Page amount
20 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (PDF)
9783319503530
Printed ISBN
978-3-319-50351-6

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