Eskes, Chantra
Alternatives for Dermal Toxicity Testing
Part I. Skin Irritation
1. Overview on Current Status of Alternative Methods and Testing Approaches for Skin Irritation Testing
Chantra Eskes, Markus Hofmann
2. Skin Irritation Hazard of Chemicals Assessed by the EpiSkin™
Nathalie Alépée, Marie Hélène Grandidier, José Cotovio
3. The EpiDerm™ Skin Irritation Test (EpiDerm™ SIT)
Helena Kandarova, Manfred Liebsch
4. An
Nathalie Alépée, Marie Hélène Grandidier, Carine Tornier, José Cotovio
5.
Hajime Kojima, Masakazu Katoh
6. The epiCS
Oliver Engelking, Horst W. Fuchs, Dirk Weisensee
Part II. Skin Corrosion
7. Overview on Current Status of Alternative Methods and Testing Approaches for Skin Corrosion Testing
Chantra Eskes, Markus Hofmann
8. The EpiSkin™ Human Epidermis Model for
Nathalie Alépée, Marie Hélène Grandidier, José Cotovio
9. The EpiDerm™ Skin Corrosion Test (EpiDerm™ SCT)
Helena Kandarova, Manfred Liebsch
10. Assessment of the Human Epidermis SkinEthic™ RHE Model for
Nathalie Alépée, Marie-Hélène Grandidier, José Cotovio
11. The epiCS
Oliver Engelking, Dirk Weisensee, Horst W. Fuchs
12. The
Rich Ulmer, Amy Wang
13. The Rat Skin Transcutaneous Electrical Resistance (TER) Test
Robert Guest
Part III. Skin Sensitization
14. Overview on Current Status and Combination of Test Methods
Erwin L. Roggen
15. The Local Lymph Node Assay
David A. Basketter, Ian Kimber, G. Frank Gerberick
16. Utilization of Peptide Reactivity Assays for the Prediction of Skin Sensitization
G. Frank Gerberick, John A. Troutman, Leslie M. Foertsch, Petra S. Kern
17. The KeratinoSens™ Assay for Skin Sensitization Screening
Andreas Natch
18. LuSens: Shedding Light on Skin Sensitization
Tzutzuy Ramirez, Annette Mehling, Robert Landsiedel
19. NCTC 2544 and IL-18 Production: A Tool for the Identification of Contact Allergens
Emanuela Corsini, Valentina Galbiati
20. Epidermal Equivalent (EE) Potency Assay
Susan Gibbs, Sander W. Spiekstra
21. The h-CLAT Method
Hitoshi Sakaguchi, Takao Ashikaga
22. U-SENS™: A U937 Cell Line Activation Test for Skin Sensitization
Nathalie Alépée, Cécile Piroird, Laurent Nardelli
23. Human Peripheral Blood Monocyte Derived Dendritic Cells Assay for the Detection and Characterization of Sensitizers
Andreas Schepky, Hendrik Reuter, Jochen Kühnl, Pierre Aeby
24. VITOSENS™
Nathalie Lambrechts, Greet Schoeters, Rosette Heuvel, Hilda Witters, Inge Nelissen, Jef Hooyberghs
25. The SENS-IS Assay
Françoise Cottrez, Elodie Boitel, Claude Auriault, Hervé Groux
26. The SenCeeTox
Donald Keller, Caroline Bauch, Prakash Patel
27. GARD: Genomic Allergen Rapid Detection
Malin Lindstedt, Kathrin Stephanie Zeller, Henrik Johansson, Carl Borrebaeck
28. Proteomics Testing for Sensitization Potency Using the Sensiderm™ TMT-SRM 10-Plex Assay
Petra Budde, Hans-Dieter Zucht, Ian Pike
29.
Bruno Miguel Neves, João Demétrio Martins, Isabel Ferreira, Ana Silva, Maria Teresa Cruz
30. An
Anne Dickinson, Xiao Nong Wang, Shaheda Ahmed
31. The Human T Cell Priming Assay (hTCPA)
Philipp R. Esser, Stefan F. Martin
32. Promising Test Systems Beyond the Current Status
Erwin L. Roggen
Part IV. UV-Induced Effects (Phototoxicity and Photoallergy)
33. Overview on the Current Status of Available Test Methods and Additional Promising Methods for Assessing UV-Induced Effects
Lorena Rigo Gaspar, Camila Martins Kawakami, Carolina Gomes Benevenuto
34. Reactive Oxygen Species Assay for Evaluating Phototoxicity Potential
Hajime Kojima, Kazuhiro Hosoi, Satomi Onoue
35. The EpiDerm™ Phototoxicity Test (EpiDerm™ H3D-PT)
Helena Kandarova, Manfred Liebsch
Part V. Skin Genotoxicity
36. Overview on Current Status
Stefan Pfuhler, Kerstin Reisinger
37. Reconstructed Skin Micronucleus Assay (RSMN)
Stefan Pfuhler, Kerstin Reisinger
38. 3D Skin Comet Assay
Kerstin Reisinger, Stefan Pfuhler
39. Role in a Testing Strategy
Kerstin Reisinger, Stefan Pfuhler
Part VI. Other Exploratory Areas of Relevance
40. Progenitor Skin Cell Therapy and Evolution of Medical Applications
Lee Ann Applegate, Paris Jafari, Corinne Scaletta, Anthony Buys Roessingh, Wassim Raffoul, Nathalie Hirt-Burri
41. Integrated Safety Strategy for the Development of Children’s Cosmetic Products Using
Andrezza di Pietro Micali Canavez, Talita M. T. P. Silveira, Natalia de Albuquerque Vita, Ana Cristina Weihermann, Caroline Radoski Neumann, Desirée Cigaran Schuck, Marcela Contador Baptista, Odivania Kruger, Carla Abdo Brohem, Marcio Lorencini
42. High-Throughput Screening Techniques
Rico Brendtke, Bart Wever, Florian Groeber, Jan Hansmann, Freia Schmid, Heike Walles
Keywords: Medicine & Public Health, Dermatology, Pharmacology/Toxicology, Animal Models
- Editor
- Eskes, Chantra
- Maibach, Howard I.
- Vliet, Erwin van
- Publisher
- Springer
- Publication year
- 2017
- Language
- en
- Edition
- 1
- Page amount
- 20 pages
- Category
- Medicine, Health Care, Mode
- Format
- Ebook
- eISBN (PDF)
- 9783319503530
- Printed ISBN
- 978-3-319-50351-6