Smith, Sylvia B.

Sigma Receptors: Their Role in Disease and as Therapeutic Targets

Smith, Sylvia B. - Sigma Receptors: Their Role in Disease and as Therapeutic Targets, ebook


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Table of contents

1. Introduction to Sigma Receptors: Their Role in Disease and as Therapeutic Targets
Sylvia B. Smith

2. Structural Perspectives on Sigma-1 Receptor Function
Assaf Alon, Hayden Schmidt, Sanduo Zheng, Andrew C. Kruse

3. A Review of the Human Sigma-1 Receptor Structure
Felipe Ossa, Jason R. Schnell, José Luis Ortega-Roldan

4. Fluorinated PET Tracers for Molecular Imaging of σ1 Receptors in the Central Nervous System
Frauke Weber, Peter Brust, Erik Laurini, Sabrina Pricl, Bernhard Wünsch

5. The Evolution of the Sigma-2 (σ2) Receptor from Obscure Binding Site to Bona Fide Therapeutic Target
Chenbo Zeng, Robert H. Mach

6. Sigma 1 Receptor and Ion Channel Dynamics in Cancer
Olivier Soriani, Raphaël Rapetti-Mauss

7. Sigma-1 Receptors Fine-Tune the Neuronal Networks
Shang-Yi Anne Tsai, Tsung-Ping Su

8. Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain
Manuel Merlos, Javier Burgueño, Enrique Portillo-Salido, Carlos Ramón Plata-Salamán, José Miguel Vela

9. Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics
Cristina Sánchez-Fernández, José Manuel Entrena, José Manuel Baeyens, Enrique José Cobos

10. Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection
Linda Nguyen, Brandon P. Lucke-Wold, Shona Mookerjee, Nidhi Kaushal, Rae R. Matsumoto

11. Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders
Yakup Albayrak, Kenji Hashimoto

12. Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease
Yu Cai, Lu Yang, Fang Niu, Ke Liao, Shilpa Buch

13. Sigma Receptors and Substance Use Disorders
Valentina Sabino, Callum Hicks, Pietro Cottone

14. Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mice
Kohji Fukunaga, Shigeki Moriguchi

15. Role of σ1 Receptors in Learning and Memory and Alzheimer’s Disease-Type Dementia
Tangui Maurice, Nino Goguadze

16. Sigma-1 Receptor in Motoneuron Disease
Renzo Mancuso, Xavier Navarro

17. The Sigma-1 Receptor–A Therapeutic Target for the Treatment of ALS?
Timur A. Mavlyutov, Erin M. Baker, Tasher M. Losenegger, Jaimie R. Kim, Brian Torres, Miles L. Epstein, Arnold E. Ruoho

18. The Role of Sigma1R in Mammalian Retina
Jing Wang, Xuezhi Cui, Penny Roon, Alan Saul, Sylvia B. Smith

19. Peeking into Sigma-1 Receptor Functions Through the Retina
Timur A. Mavlyutov, Lian-Wang Guo

20. The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma
Barbara Mysona, Neil Kansara, Jing Zhao, Kathryn Bollinger

Keywords: Biomedicine, Biomedicine general, Protein Science, Receptors

Publication year
Advances in Experimental Medicine and Biology
Page amount
13 pages
Medicine, Health Care, Mode
Printed ISBN

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