Leucine-Rich Repeat Kinase 2 (LRRK2)

Part I. Clinical and Genetic Considerations of LRRK2 Associated Parkinson’s Disease

1. Leucine-Rich Repeat Kinase (LRRK2) Genetics and Parkinson’s Disease
Edoardo Monfrini, Alessio Fonzo

2. Clinical Features of LRRK2 Carriers with Parkinson’s Disease
Meir Kestenbaum, Roy N. Alcalay

Part II. Fundamentals of LRRK2 Biology

3. LRRK2 Phosphorylation
R. Jeremy Nichols

4. Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity
An Phu Tran Nguyen, Darren J. Moore

5. LRRK2 and Autophagy
Claudia Manzoni, Patrick A. Lewis

6. Molecular Insights and Functional Implication of LRRK2 Dimerization
Laura Civiero, Isabella Russo, Luigi Bubacco, Elisa Greggio

7. LRRK2 and the Immune System
Nicolas L. Dzamko

8. Regulation of LRRK2 by Phosphatases
Jean-Marc Taymans

Part III. LRRK2 Neurodegeneration, Modeling, and Therapeutic Options

9. Models of LRRK2-Associated Parkinson’s Disease
Yulan Xiong, Ted M. Dawson, Valina L. Dawson

10. LRRK2 and the “LRRKtosome” at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives
Hardy J. Rideout, Diane B. Re

11. Interaction of LRRK2 and α-Synuclein in Parkinson’s Disease
João Paulo Lima Daher

12. Mechanisms of Mutant LRRK2 Neurodegeneration
Mark R. Cookson

13. Small-Molecule Inhibitors of LRRK2
John M. Hatcher, Hwan Geun Choi, Dario R. Alessi, Nathanael S. Gray

Keywords: Biomedicine, Neurosciences, Neurology