Metabolomics: From Fundamentals to Clinical Applications

Part I. Fundamentals and Analytical Methodologies in Metabolomics

1. Metabolomics: Definitions and Significance in Systems Biology
Aline Klassen, Andréa Tedesco Faccio, Gisele André Baptista Canuto, Pedro Luis Rocha Cruz, Henrique Caracho Ribeiro, Marina Franco Maggi Tavares, Alessandra Sussulini

2. Collection and Preparation of Clinical Samples for Metabolomics
Andrew J. Chetwynd, Warwick B. Dunn, Giovanny Rodriguez-Blanco

3. Nuclear Magnetic Resonance Strategies for Metabolic Analysis
Clement Heude, Jay Nath, John Bosco Carrigan, Christian Ludwig

4. Metabolomic Strategies Involving Mass Spectrometry Combined with Liquid and Gas Chromatography
Aline Soriano Lopes, Elisa Castañeda Santa Cruz, Alessandra Sussulini, Aline Klassen

5. Strategies Involving Mass Spectrometry Combined with Capillary Electrophoresis in Metabolomics
Karina Trevisan Rodrigues, Zuzana Cieslarová, Marina Franco Maggi Tavares, Ana Valéria Colnaghi Simionato

Part II. Statistical Analysis and Data Interpretation

6. Preprocessing and Pretreatment of Metabolomics Data for Statistical Analysis
Ibrahim Karaman

7. Chemometrics Methods and Strategies in Metabolomics
Rui Climaco Pinto

8. Computational Strategies for Biological Interpretation of Metabolomics Data
Jianguo Xia

Part III. Applications and Future Trends of Metabolomics in Clinical Cases

9. Applications of Metabolomics in Cancer Studies
Emily Grace Armitage, Michal Ciborowski

10. Chronic Diseases and Lifestyle Biomarkers Identification by Metabolomics
Annalaura Mastrangelo, Coral Barbas

11. Lipidomics, Biomarkers, and Schizophrenia: A Current Perspective
Sumit Sethi, Mirian A. F. Hayashi, Banny S. Barbosa, João G. M. Pontes, Ljubica Tasic, Elisa Brietzke

12. Spatial Metabolite Profiling by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging
Berin A. Boughton, Brett Hamilton

13. Single-Cell Metabolomics
Samy Emara, Sara Amer, Ahmed Ali, Yasmine Abouleila, April Oga, Tsutomu Masujima

Keywords: Life Sciences, Metabolomics, Gene Therapy, Gene Function