Platelets in Thrombotic and Non-Thrombotic Disorders

Part I. Physiology

1. A Brief History of Blood Platelets: A Personal View
Michael C. Berndt, Pat Metharom, Robert K. Andrews

2. Phylogeny of Blood Platelets
Stefania Momi, Viroj Wiwanitkit

3. Platelet Morphology and Ultrastructure
Harry F. G. Heijnen, Suzanne J. A. Korporaal

4. Megakaryocyte Development and Platelet Production
Joseph E. Italiano

5. Platelet Heterogeneity
Shawn Jobe

6. Regulation of Platelet Adhesion Receptors
Ana Kasirer-Friede, Sanford J. Shattil

7. The Platelet Glycoprotein Ib-IX-V Complex
José A. López

8. αIIbβ3 (GPIIb/IIIa) Structure and Function
Joel S. Bennett

9. GPVI
Yacine Boulaftali, Benoit Ho Tin Noé, Martine Jandrot-Perrus, Pierre H. Mangin

10. The Role of CLEC-2 in and Beyond the Vasculature
Julie Rayes, Alexander T. Hardy, Stephanie E. Lombard, Samantha J. Montague, Steve P. Watson, Kate L. Lowe

11. Anatomy of the Platelet Cytoskeleton
Hervé Falet

12. Platelet Proteomics and its Applications to Study Platelet-Related Disorders
Michela Michele, Kris Gevaert, Kathleen Freson

13. The Platelet PARs
Amal Arachiche, Marvin T. Nieman

14. The P2 Receptors
Béatrice Hechler, Christian Gachet

15. Platelet Prostanoids and their receptors
Susanne Fries, Tilo Grosser

16. Platelet Genomics
Zongdong Li, Dmitri V. Gnatenko, Wadie F. Bahou

17. The Platelet Transcriptome: Coding RNAs
Jesse W. Rowley, Bhanu Kanth Manne, Andrew S. Weyrich

18. Noncoding RNAs in Platelet Biology
Leonard C. Edelstein, Paul F. Bray

19. Implications of Platelet RNA to Vascular Health and Disease
Lauren Clancy, Jane E. Freedman

20. GTPases
Lucia Stefanini, Robert H. Lee, Wolfgang Bergmeier

21. Platelet Signalling: Calcium
Alan G. S. Harper, Stewart O. Sage

22. Platelet Signaling: Protein Phosphorylation
Satya P. Kunapuli, Dheeraj Bhavanasi, John C. Kostyak, Bhanu Kanth Manne

23. Platelet Adhesion
Elizabeth E. Gardiner, Robert K. Andrews

24. Platelet Shape Change
Joseph E. Aslan

25. The Migration of Platelets and their Interaction with Other Migrating Cells
Eleonora Petito, Stefania Momi, Paolo Gresele

26. Platelet Secretion
Robert Flaumenhaft

27. A Systems Approach to the Platelet Signaling Network and the Hemostatic Response to Injury
Lawrence F. Brass, Peisong Ma, Maurizio Tomaiuolo, Scott L. Diamond, Timothy J. Stalker

28. Platelet-Derived Microparticles
Sylvie Cointe, Romaric Lacroix, Françoise Dignat-George

29. Platelet Interactions with the Blood Vessel Wall
Bradley A. Maron, Joseph Loscalzo

30. Platelet–Leukocyte Interactions
Virgilio Evangelista, Licia Totani, Angelo A. Manfredi, Norma Maugeri

31. The Role of Platelets in Lymphangiogenesis and Neoangiogenesis
Katsue Suzuki-Inoue, Toshiaki Shirai

32. Platelets and Coagulation
Johan W. M. Heemskerk, Judith M. E. M. Cosemans, Paola E. J. Meijden

33. Platelets and Fibrinolysis
Mario Colucci, Nicola Semeraro, Fabrizio Semeraro

34. Platelets and Immunity
Ingrid Slaba, Paul Kubes

35. Platelets in Neurological Disorders
Ilaria Canobbio, Gianni F. Guidetti, Mauro Torti

36. The Role of Platelets During Development and Reproduction
Shrey Kohli, Berend Isermann

37. Platelet-Derived Inhibitors of Platelet Activation
A. J. Unsworth, A. P. Bye, J. M. Gibbins

Part II. Methodology

38. Platelet Function Tests
Marie Lordkipanidzé, Paul Harrison

39. Platelet Counting and Measurement of Platelet Dimensions
Patrizia Noris, Carlo Zaninetti

40. Flow Cytometry
Cecilia Carubbi, Elena Masselli, Marco Vitale

41. Platelet Aggregation
Catherine P. M. Hayward, Karen A. Moffat

42. Platelet Secretion
Andreas Wersäll, Ewelina M. Golebiewska, Alastair W. Poole

43. Platelet Activation Under Conditions of Flow
Philip G. Groot, Rolf T. Urbanus

44. In Vivo Imaging of Thrombosis and Hemostasis
Anil K. Chauhan

45. Monitoring of Antiplatelet Therapy
Udaya S. Tantry, Aung Myat, Paul A. Gurbel

46. Mouse Models of Thrombosis
Deya Cherpokova, Bernhard Nieswandt

47. Next-Generation Sequencing in the Study of Platelets
Vincenzo C. Leo

Part III. Pathology: Hemostatic Disorders

48. Approach to the Patient with Platelet-Related Bleeding
Diego Mezzano, Jaime Pereira

49. Inherited Thrombocytopenias
Carlo L. Balduini, Federica Melazzini, Alessandro Pecci

50. Immune Thrombocytopenia: Where Are We Now?
Nichola Cooper, James Bussel

51. Fetal and Neonatal Alloimmune Thrombocytopenia
Gérald Bertrand, Cécile Kaplan

52. Drug-Induced Thrombocytopenia: Pathogenesis, Diagnosis and Management
Beng H. Chong, James J. -H. Chong

53. Heparin-Induced Thrombocytopenia
Andreas Greinacher, Tamam Bakchoul, Adam Cuker, Theodore (Ted) E. Warkentin

54. Thrombocytopenia in Pregnancy
Shruti Chaturvedi, Keith McCrae

55. Thrombocytopenia in the Newborn
Robert Carr, Timothy Watts, Catherine Rea

56. Thrombocytopenia in Patients with Solid Tumors or Hematologic Malignancies
Caroline I. Piatek, Howard A. Liebman

57. Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome
Johanna A. Kremer Hovinga

58. Thrombocytosis and Essential Thrombocythaemia
Samah Alimam, Claire N. Harrison

59. Platelet Adhesive Protein Defect Disorders
Shinji Kunishima, Hirokazu Kashiwagi

60. Defects of Soluble Agonists
Marco Cattaneo

61. Defects of Platelet Granules and Secretion
Barbara Zieger

62. Defects of Platelet Signal Transduction
Binggang Xiang, Zhenyu Li

63. Alterations of the Platelet Procoagulant or Fibrinolytic Functions
Bernard Payrastre, Marie-Christine Alessi, Pierre Sié

64. Acquired Disorders of Platelet Function
Rüdiger E. Scharf

Part IV. Pathology: Thrombotic Disorders

65. Platelets in Arterial Thrombosis
Christian Schulz, Steffen Massberg

66. Platelets in Atherosclerosis
Madhumita Chatterjee, Meinrad Gawaz

67. Platelets in Acute Coronary Syndromes
Mark R. Thomas, Robert F. Storey

68. Platelets in Acute Ischemic Stroke
Guido Stoll, Christoph Kleinschnitz, Bernhard Nieswandt

69. Platelets in Deep Venous Thrombosis and Pulmonary Embolism
Ingrid Pabinger, Julia Riedl, Simon Panzer

70. Gene Regulation of Platelet Function
Dmitri V. Gnatenko, Zongdong Li, Wadie F. Bahou

Part V. Pathology: Non Hemostatic or Thrombotic Disorders

71. Platelets and Bacterial Infections
Matthew T. Rondina, Olivier Garraud, Hansjörg Schwertz

72. Virus–Platelet Associations
Edward L. G. Pryzdial, Bryan H. Lin, Michael R. Sutherland

73. Platelets in Malarial Infection: Protective or Pathological?
Simon Foote, Gaétan Burgio, Brendan McMorran

74. Platelets: “First Responders” in Cancer Progression and Metastasis
David G. Menter, Jennifer S. Davis, Stephanie C. Tucker, Ernest Hawk, John D. Crissman, Anil K. Sood, Scott Kopetz, Kenneth V. Honn

75. Platelets and Inflammatory Disorders of Connective Tissue
Jerry Ware, Steven R. Post

76. Platelets and Skin Disorders
Risa Tamagawa-Mineoka

77. Platelets and Airway Diseases
Stefania Momi, Simon Pitchford, Paolo Gresele, Clive P. Page

78. Hemostatic and Non-hemostatic Functions of Platelets in Patients with Liver Disease
Ton Lisman

79. Platelets and Renal Disorders
Jens Lutz, Kerstin Jurk

80. Platelets in Inflammatory Bowel Disease
Felix Becker, Thorsten Vowinkel

81. Platelets and Neurodegenerative Diseases
Lili Donner, Margitta Elvers

82. Platelets and Diabetes
Francesca Santilli, Paola Simeone, Rossella Liani, Giovanni Davì

Part VI. Pharmacology

83. Aspirin
Carlo Patrono

84. Pharmacology: Inhibitors of P2Y12

Lisa Gross, Dániel Aradi, Dirk Sibbing

85. Glycoprotein IIb/IIIa Antagonists
Madhan Shanmugasundaram, David J. Moliterno

86. Dipyridamole and PDE Inhibitors
Paolo Gresele, Stefania Momi, Emanuela Falcinelli

87. PAR Antagonists
Patrícia O. Guimarães, Pierluigi Tricoci

88. Inhibitors of Platelet Adhesion to VWF and Collagen
Claudia Tersteeg, Simon F. Meyer, Hans Deckmyn

89. Pharmacogenomics of Antiplatelet Drugs
Chiara Cerletti, Benedetta Izzi, Licia Iacoviello, Giovanni Gaetano

90. Targeting Intraplatelet Signaling Pathways as Potential Antithrombotic Strategy
Patrick Andre

Part VII. Therapy

91. Antiplatelet Therapy in Patients with Coronary Artery Disease
Harsh Patel, Neal S. Kleiman

92. Antiplatelet Therapy in Cerebrovascular Disorders
Ilana Spokoyny, Gregory Albers

93. Antiplatelet Therapy in Peripheral Artery Disease
Francesco Violi, Stefania Basili, Jeffrey S. Berger, William R. Hiatt

94. Platelet Transfusions
Randolph B. Lyde, Mortimer Poncz, Michele P. Lambert

95. Platelet-Rich Plasma in Regenerative Medicine
Joseph Alsousou, Paul Harrison

96. Therapeutic Use of Thrombopoietin Receptor Agonists
Michael D. Tarantino, Sarah Chalmers

97. Gene Therapy
Qizhen Shi, Robert R. Montgomery

Keywords: Biomedicine, Pharmacology/Toxicology, Hematology, Human Physiology, Cardiology, Molecular Medicine