Systems Pharmacology and Pharmacodynamics

Part I. Systems Modeling

1. Systems Pharmacology and Pharmacodynamics: An Introduction
Donald E. Mager, Holly H. C. Kimko

2. Role of Systems Modeling in Regulatory Drug Approval
Vikram Sinha, Shiew-Mei Huang, Darrell R. Abernethy, Yaning Wang, Ping Zhao, Issam Zineh

3. Quantitative Systems Pharmacology: Applications and Adoption in Drug Development
Saroja Ramanujan, Kapil Gadkar, Ananth Kadambi

4. Systems Pharmacology: An Overview
Marc R. Birtwistle, Jens Hansen, James M. Gallo, Sreeharish Muppirisetty, Peter Man-Un Ung, Ravi Iyengar, Avner Schlessinger

5. Discrete Dynamic Modeling: A Network Approach for Systems Pharmacology
Steven Nathaniel Steinway, Rui-Sheng Wang, Reka Albert

6. Kinetic Models of Biochemical Signaling Networks
Mehdi Bouhaddou, Marc R. Birtwistle

7. Mechanistic Models of Physiological Control Systems
Michael C. K. Khoo, Wen-Hsin Hu, Patjanaporn Chalacheva

Part II. Pharmacodynamics

8. Foundations of Pharmacodynamic Systems Analysis
William J. Jusko

9. Direct, Indirect, and Signal Transduction Response Modeling
Wojciech Krzyzanski

10. Irreversible Pharmacodynamics
Alberto Russu, Italo Poggesi

11. Feedback Control Indirect Response Models
Yaping Zhang, David Z. D’Argenio

12. Nonlinear Mixed Effects Modeling in Systems Pharmacology
Peter L. Bonate, Amit Desai, Ahsan Rizwan, Zheng Lu, Stacey Tannenbaum

13. Detecting Pharmacokinetic and Pharmacodynamic Covariates from High-Dimensional Data
Jonathan Knights, Murali Ramanathan

Part III. Multi-scale Models of Drug Action

14. Multi-scale Modeling of Drug Action in the Nervous System
Hugo Geerts, Patrick Roberts, Athan Spiros, Robert Carr

15. Mechanistic Modeling of Inflammation
Jeremy D. Scheff, Kubra Kamisoglu, Ioannis P. Androulakis

16. Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities
Yoshiaki Kariya, Masashi Honma, Hiroshi Suzuki

17. Translational Modeling of Antibacterial Agents
Gauri G. Rao, Neang S. Ly, Brian T. Tsuji, Jürgen B. Bulitta, Alan Forrest

18. Viral Dynamic Modeling of Hepatitis C Virus Infection: Past Successes and Future Challenges
Eric L. Haseltine, Holly H. C. Kimko

19. Using Systems Pharmacology to Advance Oncology Drug Development
Daniel C. Kirouac

20. Systems Pharmacology Modeling in Type 2 Diabetes Mellitus
James R. Bosley, Tristan S. Maurer, Cynthia J. Musante

Keywords: Biomedicine, Pharmaceutical Sciences/Technology, Mathematical and Computational Biology, Medical Biochemistry