Fundamentals of Pediatric Drug Dosing

1. Pediatric Drug Development and the Regulatory Changes That Are Creating the Science of Pediatric Dosing
Gilbert J. Burckart

2. Pediatric Physiology
Iftekhar Mahmood

3. Developmental Pharmacology: Impact on Pharmacokinetics and Pharmacodynamics of Drugs
Iftekhar Mahmood

4. Pediatric Clinical Trial Design and Dosing
Dionna Green, Valerie Amspacher

5. Application of Allometric Principles in Pediatric Drug Development
Iftekhar Mahmood

6. Population Pharmacokinetics in Pediatric Drug Development
Jeremiah D. Momper, John Bradley, Brookie M. Best

7. Scaling Dose-Exposure-Response from Adults to Children
Ine Skottheim Rusten, Anna Nordmark, Susan Cole, Joseph F. Standing, Sofia Friberg Hietala, Wei Zhao, Valeria Gigante, Anna Karin Hamberg, Gérard Pons, María Jesús Garrido, Johannes Taminiau, Norbert Benda, Frederike Lentz, Flora Musuamba Tshinanu, Andrew Thomson, Paolo Tomasi, Cecile Ollivier, Ralf Herold, Efthymios Manolis

8. Applications of Physiologically Based Pharmacokinetic (PBPK) Models for Pediatric Populations
Peng Duan, Jeffrey W. Fisher, Jian Wang

9. Perinatal Pharmacology and Maternal/Fetal Dosing
Iftekhar Mahmood, Gilbert J. Burckart, Robert M. Ward

Keywords: Medicine & Public Health, Pediatrics, Pharmacotherapy, General Practice / Family Medicine