The Role of Pendrin in Health and Disease

1. Introduction
Silvia Dossena, Markus Paulmichl

Part I. The Role of Pendrin in the Inner Ear

2. Mouse Models Reveal the Role of Pendrin in the Inner Ear
Philine Wangemann, Andrew J. Griffith

3. The Slc26a4

loop
Mouse Model for Pendred’s Syndrome and Nonsyndromic Deafness
Amiel A. Dror, Karen B. Avraham

4. Pendrin-Linked Deafness in Humans
Sebastian Roesch, Miklós Tóth, Gerd Rasp

5. Genetic Diagnosis of Deafness
Sueli Matilde Silva Costa, Priscila Zonzini Ramos, Fábio Tadeu Arrojo Martins, Edi Lúcia Sartorato

Part II. The Role of Pendrin in the Thyroid

6. Hypothyroidism, Subclinical Hypothyroidism and Related Diagnostic Tools
Gregor Schweighofer Zwink, Christian Pirich

7. The Controversial Role of Pendrin in Thyroid Cell Function and in the Thyroid Phenotype in Pendred Syndrome
Peter Kopp, Aigerim Bizhanova, Liuska Pesce

Part III. The Role of Pendrin in the Kidney

8. Pendrin and Its Partners in the Kidney: Roles in Vascular Volume and Acid Base Regulation
Manoocher Soleimani, Giovanna Valenti

Part IV. The Role of Pendrin in the Airways

9. The Role of Pendrin in the Airways: Links with Asthma and COPD
Kenji Izuhara, Shoichi Suzuki, Charity Nofziger, Masahiro Ogawa, Shoichiro Ohta, Yasuhiro Nanri, Yasutaka Mitamura, Tomohito Yoshihara, Nicoletta Pedemonte, Luis J. V. Galietta, Markus Paulmichl

Part V. The Pendrin Gene and Protein

10. Transcriptional Regulation and Epigenetics of Pendrin
Julia Rozenfeld, Charity Nofziger, Orly Kladnitsky, Seth L. Alper, Israel Zelikovic

11. The Pendrin Polypeptide
Silvia Dossena, Emanuele Bernardinelli, Alok K. Sharma, Seth L. Alper, Markus Paulmichl

Keywords: Biomedicine, Molecular Medicine, Otorhinolaryngology, Endocrinology, Human Genetics