Carrasco, Martin

Modern Proteomics – Sample Preparation, Analysis and Practical Applications

Carrasco, Martin - Modern Proteomics – Sample Preparation, Analysis and Practical Applications, ebook


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ISBN: 9783319414485
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Table of contents

Part I. Sample Preparation Strategies for Proteomics

1. Proteomes, Their Compositions and Their Sources
Anna Kwasnik, Claire Tonry, Angela Mc Ardle, Aisha Qasim Butt, Rosanna Inzitari, Stephen R. Pennington

2. Protein Fractionation and Enrichment Prior to Proteomics Sample Preparation
Andrew J. Alpert

3. Sample Preparation for Mass Spectrometry-Based Proteomics; from Proteomes to Peptides
John C. Rogers, Ryan D. Bomgarden

4. Plant Structure and Specificity – Challenges and Sample Preparation Considerations for Proteomics
Sophie Alvarez, Michael J. Naldrett

5. Improving Proteome Coverage by Reducing Sample Complexity via Chromatography
Uma Kota, Mark L. Stolowitz

Part II. Mass Spectrometry for Proteomics Analysis

6. Database Search Engines: Paradigms, Challenges and Solutions
Kenneth Verheggen, Lennart Martens, Frode S. Berven, Harald Barsnes, Marc Vaudel

7. Mass Analyzers and Mass Spectrometers
Anthony M. Haag

8. Top-Down Mass Spectrometry: Proteomics to Proteoforms
Steven M. Patrie

Part III. Bioinformatic Tools for Proteomics data Analysis and Interpretation

9. Platforms and Pipelines for Proteomics Data Analysis and Management
Marius Cosmin Codrea, Sven Nahnsen

10. Tandem Mass Spectrum Sequencing: An Alternative to Database Search Engines in Shotgun Proteomics
Thilo Muth, Erdmann Rapp, Frode S. Berven, Harald Barsnes, Marc Vaudel

11. Visualization, Inspection and Interpretation of Shotgun Proteomics Identification Results
Ragnhild R. Lereim, Eystein Oveland, Frode S. Berven, Marc Vaudel, Harald Barsnes

12. Protein Inference
Zengyou He, Ting Huang, Can Zhao, Ben Teng

13. Modification Site Localization in Peptides
Robert J. Chalkley

14. Useful Web Resources
Andre Bui, Maria D. Person

15. Mass Spectrometry-Based Protein Quantification
Yun Chen, Fuqiang Wang, Feifei Xu, Ting Yang

16. Bioinformatics Tools for Proteomics Data Interpretation
Karla Grisel Calderón-González, Jesús Hernández-Monge, María Esther Herrera-Aguirre, Juan Pedro Luna-Arias

Part IV. Applications of Proteomics Technologies in Biological and Medical Sciences

17. Identification, Quantification, and Site Localization of Protein Posttranslational Modifications via Mass Spectrometry-Based Proteomics
Mi Ke, Hainan Shen, Linjue Wang, Shusheng Luo, Lin Lin, Jie Yang, Ruijun Tian

18. Protein-Protein Interaction Detection Via Mass Spectrometry-Based Proteomics
Benedetta Turriziani, Alexander Kriegsheim, Stephen R. Pennington

19. Protein Structural Analysis via Mass Spectrometry-Based Proteomics
Antonio Artigues, Owen W. Nadeau, Mary Ashley Rimmer, Maria T. Villar, Xiuxia Du, Aron W. Fenton, Gerald M. Carlson

Part V. Clinical Proteomics

20. Introduction to Clinical Proteomics
John E. Wiktorowicz, Allan R. Brasier

21. Discovery of Candidate Biomarkers
John E. Wiktorowicz, Kizhake V. Soman

22. Statistical Approaches to Candidate Biomarker Panel Selection
Heidi M. Spratt, Hyunsu Ju

23. Qualification and Verification of Protein Biomarker Candidates
Yingxin Zhao, Allan R. Brasier

24. Protocol for Standardizing High-to-Moderate Abundance Protein Biomarker Assessments Through an MRM-with-Standard-Peptides Quantitative Approach
Andrew J. Percy, Juncong Yang, Andrew G. Chambers, Yassene Mohammed, Tasso Miliotis, Christoph H. Borchers

Keywords: Life Sciences, Proteomics, Protein Science, Bioinformatics

Publication year
Advances in Experimental Medicine and Biology
Page amount
9 pages
Natural Sciences
Printed ISBN

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