Selenium

Part I. The Machinery of Selenoprotein Biosynthesis

1. Selenocysteine tRNA[Ser]Sec: From Nonsense Suppressor tRNA to the Quintessential Constituent in Selenoprotein Biosynthesis
Bradley A. Carlson, Byeong Jae Lee, Petra A. Tsuji, Ryuta Tobe, Jin Mo Park, Ulrich Schweizer, Vadim N. Gladyshev, Dolph L. Hatfield

2. Eukaryotic Mechanisms of Selenocysteine Incorporation and Its Reconstitution In Vitro
Mark H. Pinkerton, Paul R. Copeland

3. Probing Selenoprotein Translation by Ribosome Profiling
Michael T. Howard

4. Pathways in De Novo Biosynthesis of Selenocysteine and Cysteine in Eukaryotes
Vadim N. Gladyshev, Bradley A. Carlson, Dolph L. Hatfield

5. Prokaryotic Selenoprotein Biosynthesis and Function
Michael Rother

6. The Role of Selenium in Human Evolution
Louise White, Sergi Castellano

7. The Chemistry of Selenocysteine in Proteins
Rebecca N. Dardashti, Linoy Dery, Reem Mousa, Shahar Dery, Post S. Reddy, Norman Metanis

8. Evolution of Selenophosphate Synthetase
Marco Mariotti, Didac Santesmasses, Roderic Guigó

9. Structure and Mechanism of Selenocysteine Synthases
Malgorzata Dobosz-Bartoszek, Miljan Simonović

10. Mechanism, Structure, and Biological Role of Selenocysteine Lyase
Hisaaki Mihara, Ryuta Tobe, Nobuyoshi Esaki

Part II. Selenoproteins, Their Occurrence and Function

11. Eukaryotic Selenoproteomes
Vadim N. Gladyshev

12. Prokaryotic Selenoproteins and Selenoproteomes
Yan Zhang

13. Functional Genomics of Selenoproteins and Se-responsive Pathways
Catherine Méplan, John Hesketh

14. Selenium Regulation of the Selenoprotein and Non-selenoprotein Transcriptomes in a Variety of Species
Roger A. Sunde

15.
77Se NMR Spectroscopy of Selenoproteins
Jun Liu, Sharon Rozovsky

16. Thioredoxin Reductase 1 as an Anticancer Drug Target
Edward E. Schmidt, Elias S. J. Arnér

17. Basics and News on Glutathione Peroxidases
Leopold Flohé, Regina Brigelius-Flohé

18. Glutathione Peroxidase 4
Matilde Maiorino, Valentina Bosello-Travain, Giorgio Cozza, Giovanni Miotto, Laura Orian, Antonella Roveri, Stefano Toppo, Mattia Zaccarin, Fulvio Ursini

19. The 15 kDa Selenoprotein: Insights into Its Regulation and Function
Bradley A. Carlson, Janelle M. Hartman, Petra A. Tsuji

20. Selenoprotein K and Protein Palmitoylation in Regulating Immune Cell Functions
Peter R. Hoffmann

21. Selenoprotein M: Structure, Expression and Functional Relevance
Ting Gong, Marla J. Berry, Matthew W. Pitts

22. Selenoprotein P and Selenium Distribution in Mammals
Ulrich Schweizer, Lutz Schomburg, Josef Köhrle

23. Selenoprotein T: From Discovery to Functional Studies Using Conditional Knockout Mice
Loubna Boukhzar, Yannick Tanguy, Houssni Abid, Matthieu Castex, Abdallah Hamieh, Ifat Alsharif, Dorthe Cartier, Gaëtan Prevost, Anthony Falluel-Morel, Isabelle Lihrmann, Abdeslam Chagraoui, Youssef Anouar

24. Biochemistry and Function of Methionine Sulfoxide Reductase
Byung Cheon Lee

Part III. Dietary Selenium and Its Impact on Human Health

25. Selenium: Dietary Sources, Human Nutritional Requirements and Intake Across Populations
Kristin M. Peters, Sarah E. Galinn, Petra A. Tsuji

26. Human Clinical Trials Involving Selenium
Lutz Schomburg

27. Status of Dietary Selenium in Cancer Prevention
Gerald F. Combs, Lin Yan

28. Selenium in HIV/AIDS
Adriana Campa, Sabrina Sales Martinez, Marianna K. Baum

29. Genetic Variations in the Genes for Selenoproteins Implicate the Encoded Proteins in Cancer Etiology
Rama Saad, Alan M. Diamond

30. Is Adequate Selenium Important for Healthy Human Pregnancy?
Margaret P. Rayman

31. The Epidemiology of Selenium and Human Health
Marco Vinceti, Barbara Burlingame, Tommaso Filippini, Androniki Naska, Annalisa Bargellini, Paola Borella

32. Sex-Specific Differences in Biological Effects and Metabolism of Selenium
Lutz Schomburg

33. Selenium and Endocrine Tissues
Josef Köhrle

34. Selenium Antagonism with Mercury and Arsenic: From Chemistry to Population Health and Demography
Anatoly V. Skalny, Margarita G. Skalnaya, Alexandr A. Nikonorov, Alexey A. Tinkov

35. Biological Selenium Species and Selenium Speciation in Biological Samples
Katarzyna Bierla, Joanna Szpunar, Ryszard Lobinski

Part IV. Selenoproteins in Human Health

36. Selenoproteins in Nervous System Development, Function and Degeneration
Ulrich Schweizer

37. Interplay of Selenoproteins and Different Antioxidant Systems in Various Cancers
Petra A. Tsuji, Bradley A. Carlson, Byeong Jae Lee, Vadim N. Gladyshev, Dolph L. Hatfield

38. Glutathione Peroxidase 2, a Selenoprotein Exhibiting a Dual Personality in Preventing and Promoting Cancer
Regina Brigelius-Flohé, Anna P. Kipp

39. Selenoproteins in Cardiovascular Redox Pathology
Diane E. Handy, Joseph Loscalzo

40. What Do We Know About Selenium Contributions to Muscle Physiology?
Alain Lescure, Mickaël Briens, Ana Ferreiro

41. Tissue-Specific Regulation of Thyroid Status by Selenodeiodinases
Alessandro Marsili, P. Reed Larsen, Ann Marie Zavacki

42. The Role of Selenoproteins in Resolution of Inflammation
Bastihalli T. Diwakar, Emily R. Finch, Chang Liao, Ashley E. Shay, K. Sandeep Prabhu

43. Glutathione Peroxidase 4 and Ferroptosis
José Pedro Friedmann Angeli, Bettina Proneth, Marcus Conrad

44. Mutations in Humans That Adversely Affect the Selenoprotein Synthesis Pathway
Erik Schoenmakers, Nadia Schoenmakers, Krishna Chatterjee

45. Alteration of Selenoprotein Expression During Stress and in Aging
Zahia Touat-Hamici, Yona Legrain, Jordan Sonet, Anne-Laure Bulteau, Laurent Chavatte

Part V. Biological Models for Elucidating the Role of Selenium and Selenoproteins in Biology and Medicine

46. Selenocysteine tRNA[Ser]Sec Mouse Models for Elucidating Roles of Selenoproteins in Health and Development
Bradley A. Carlson

47. Mouse Models that Target Individual Selenoproteins
Marcus Conrad, Ulrich Schweizer

48. The Naked Mole Rat and Selenium
Alexei V. Lobanov, Vadim N. Gladyshev

49. Glutathione Peroxidase 1: Models for Diabetes and Obesity
Xin Gen Lei, Marko Vatamaniuk

50. Selenium in Livestock and Other Domestic Animals
Peter F. Surai, Vladimir I. Fisinin

Keywords: Biomedicine, Immunology, Nutrition