Biomarkers of the Tumor Microenvironment

Part I. Basic Mechanisms and Biomarkers

1. The Role of the Tumor Microenvironment in Regulating Angiogenesis
Randolph S. Watnick

2. More Than a Barrier: How the Endothelium Instructs Metastasis
Candice Alexandra Grzelak, Andrea Rachel Lim, Cyrus Michael Ghajar

3. Tissue-Based Biomarkers of Tumor-Vascular Interactions
Lars A. Akslen

4. Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?
Cédric Zeltz, Roya Navab, Marion Kusche-Gullberg, Ming-Sound Tsao, Donald Gullberg

5. Stromal PDGF Receptors as Prognostic and Predictive Biomarkers
Arne Östman

6. The Function and Diagnostic Potential of Adipocyte-Derived Factors in the Tumor Microenvironment
Joan Chang, Andrew C. Dudley

7. Inflammation and Cancer: The Role of Lipid Signaling in the Continuum Between Two Ends of the Tumor Spectrum
Megan L. Sulciner, Molly M. Gilligan, Bruce R. Zetter, Dipak Panigrahy

8. Cancer Immunity and Immune Evasion Mechanisms
Stalin Chellappa, Einar M. Aandahl, Kjetil Taskén

9. Drivers of EMT and Immune Evasion
Rolf A. Brekken, Katarzyna Wnuk-Lipinska

10. Inflammatory Biomarkers for Cancer
Alexandre Corthay, Guttorm Haraldsen

11. Immunology of Solid Tumors Beyond Tumor-Infiltrating Lymphocytes: The Role of Tertiary Lymphoid Structures
Gert G. G. M. Eynden, Roberto Salgado, Karen Willard-Gallo

12. The Role of Platelets in the Tumor Microenvironment
Kelly E. Johnson, Sandra S. McAllister, Joseph E. Italiano, Elisabeth M. Battinelli

13. Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments
Tina Rayes, Dingcheng Gao, Nasser K. Altorki, Thomas R. Cox, Janine T. Erler, Vivek Mittal

14. Neuropilin 1 and Neuropilin 2: Cancer Progression and Biomarker Analysis
Xiaoran Li, Diane R. Bielenberg

15. The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance
Kjersti T. Davidsen, Gry S. Haaland, Maria K. Lie, James B. Lorens, Agnete S. T. Engelsen

Part II. Organ Related Biomarker Studies

16. Gene Expression Signatures of the Tumor Microenvironment: Relation to Tumor Progress in Breast Cancer
Elisabeth Wik, Lars A. Akslen

17. MR-Derived Biomarkers for Cancer Characterization
Eugene Kim, Morteza Esmaeili, Siver A. Moestue, Tone F. Bathen

18. The Influence of Tissue Architecture on Drug Response: Anticancer Drug Development in High-Dimensional Combinatorial Microenvironment Platforms
Chun-Han Lin, Mark A. LaBarge

19. Models of Tumor Progression in Prostate Cancer
Waqas Azeem, Yaping Hua, Karl-Henning Kalland, Xisong Ke, Jan Roger Olsen, Anne Margrete Øyan, Yi Qu

20. Tumor-Host Interactions in Malignant Gliomas
Lina Leiss, Ercan Mutlu, Mohummad Aminur Rahman, Per Øyvind Enger

21. The Tumor Microenvironment in Cutaneous Melanoma: Friend or Foe
Oddbjørn Straume, Cornelia Schuster

22. Biomarker Panels and Contemporary Practice in Clinical Trials of Targeted Therapy
Nina Louise Jebsen, Samantha Scarlett, Bergrun Tinna Magnusdottir, Bjørn Tore Gjertsen

Keywords: Medicine & Public Health, Pathology, Cancer Research