Pituitary Adenylate Cyclase Activating Polypeptide — PACAP

Part I. Evolutionary Aspects of PACAP

1. Molecular Evolution of Pituitary Adenylyl Cyclase-Activating Polypeptide Subfamily and Cognate Receptor Subfamily
Jason S. W. On, Billy K. C. Chow

2. Occurrence, Distribution, and Physiological Function of Pituitary Adenylyl Cyclase-Activating Polypeptide in Invertebrate Species
Zsolt Pirger, Nora Krajcs, Tibor Kiss

3. PACAP-Like Compounds of Earthworms: Identification and Putative Functions from Embryonic Development to Brain Regeneration
Laszlo Molnar, Peter Engelmann, Anita Steib, Edit Pollak

4. PACAP and Learning in Invertebrates
Ildiko Kemenes, Gyorgy Kemenes

Part II. Effects of PACAP in Neuronal Development

5. PACAP and Neural Progenitor Cells
Dan Lindholm, Johanna Mäkelä, Laura Korhonen

6. PACAP and Neural Development
Jun Watanabe, Tamotsu Seki, Seiji Shioda

7. PACAP Modulates Distinct Neuronal Components to Induce Cell-Specific Plasticity at Central and Autonomic Synapses
Eric R. Starr, Joseph F. Margiotta

Part III. PACAP Receptors and Signalling

8. The Pharmacophoric Determinants of PACAP
Alain Fournier, Steve Bourgault, David Chatenet

9. PACAP-Derived Carriers: Mechanisms and Applications
David Chatenet, Alain Fournier, Steve Bourgault

10. Effects and Development of TAT-Tagged PACAP/VIP and Related Peptides
Rongjie Yu

Part IV. Presence and Physiological Functions of PACAP in Diverse Systems

11. Presence and Role of PACAP in Endocrine Glands of Mammals
Katalin Koves

12. Distribution of PACAP in the Mammalian Nervous System
Katalin Koves

13. Multiple Mechanisms Contribute to the PAC1 Modulation of Parasympathetic Cardiac Neuron Excitability
Rodney L. Parsons, John D. Tompkins, Jean C. Hardwick, Laura A. Merriam, Beatrice M. Girard, Victor May

14. PACAP in the Circadian Timing System: Learning from Knockout Models
Jens Hannibal

15. The Role of PACAP in the Regulation of Body Temperature
Andras Garami, Eszter Pakai, Zoltan Rumbus, Margit Solymar

Part V. Presence and Functions of PACAP in the Gastrointestinal and Urinary Tracts

16. PACAP Regulation of Gastrointestinal Function and Obesity
John P. Vu, Jihane N. Benhammou, Deepinder Goyal, Leon Luong, Suwan Oh, Patrizia Germano, Joseph R. Pisegna

17. Protective Intestinal Effects of Pituitary Adenylate Cyclase Activating Polypeptide
Gabriella Horvath, Anita Illes, Markus M. Heimesaat, Attila Bardosi, Sebastian Bardosi, Andrea Tamas, Balazs D. Fulop, Balazs Opper, Jozsef Nemeth, Andrea Ferencz, Dora Reglodi

18. Renoprotective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide 38 (PACAP38)
M-Altaf Khan, Vecihi Batuman

19. Neuroplasticity of PACAP Expression and Function in Micturition Reflex Pathways
Eric J. Gonzalez, Beatrice Girard, Karen M. Braas, Victor May, Margaret A. Vizzard

Part VI. Functions of PACAP in the Skeletal System

20. Role of PACAP and VIP Signalling in Regulation of Chondrogenesis and Osteogenesis
Tamas Juhasz, Andrea Tamas, Roza Zakany, Dora Reglodi

21. Role of PACAP/VIP in Bone and Joint Physiology and Pathophysiology
Balint Botz, Zsuzsanna Helyes

Part VII. PACAP in the Regulation of the Reproductive System

22. Role of PACAP and Its PACAP Type I Receptor in the Central Control of Reproductive Hormones
Haruhiko Kanasaki, Aki Oride, Mijiddorj Tselmeg, Unurjargal Sukhbaatar, Satoru Kyo

23. Occurrence and Functions of PACAP in the Placenta
Gabriella Horvath, Jozsef Nemeth, Reka Brubel, Balazs Opper, Miklos Koppan, Andrea Tamas, Laszlo Szereday, Dora Reglodi

24. PACAP in the Reproductive System
Rita Canipari, Virginia Paolo, Marzia Barberi, Sandra Cecconi

Part VIII. PACAP in Biological Barriers and Barrier-Forming Cells

25. Transport of Pituitary Adenylate Cyclase Activating Polypeptide Across the Blood–Brain Barrier: Consequences for Disease States and Therapeutic Effects
William A. Banks

26. Effects of PACAP on Biological Barriers
Imola Wilhelm, Istvan A. Krizbai

27. Role of PACAP in Astrocytes and Astrocytic Tumors
Tomoya Nakamachi

28. Multiple Actions of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Schwann Cell Biology
Alessandro Castorina

Part IX. PACAP in Sensory Systems

29. Sniffing Out a Role for PACAP in the Olfactory System
Mary T. Lucero

30. Protective Effects of PACAP in the Retina
Tamas Atlasz, Alexandra Vaczy, Dora Werling, Peter Kiss, Andrea Tamas, Krisztina Kovacs, Eszter Fabian, Timea Kvarik, Barbara Mammel, Bese Danyadi, Emese Lokos, Dora Reglodi

31. Pituitary Adenylate Cyclase-Activating Polypeptide in the Auditory System
Balazs D. Fulop, Dora Reglodi, Adrienn Nemeth, Andrea Tamas

Part X. Neuroprotective effects of PACAP

32. PACAP Signaling in Neuroprotection
Destiny-Love Manecka, Loubna Boukhzar, Anthony Falluel-Morel, Isabelle Lihrmann, Youssef Anouar

33. PACAP Expression and Plasticity in the Peripheral Nervous System
Karen M. Braas, Rodney L. Parsons, Margaret A. Vizzard, James A. Waschek, Victor May

34. The Neuropeptide PACAP, a Potent Disease Modifier Candidate for Brain Stroke Treatment
Coralie Brifault, David Vaudry, Olivier Wurtz

Part XI. PACAP in the Pathomechanism of Migraine and Pain

35. Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) in Migraine Pathophysiology
Lars Edvinsson

36. PACAP Regulation of Vascular Tone: Differential Mechanism Among Vascular Beds
Arsalan U. Syed, Masayo Koide, Victor May, George C. Wellman

37. PACAP Circuits Mediating the Sensory and Behavioral Consequences of Pain
Galen Missig, Rodney L. Parsons, Margaret A Vizzard, Sayamwong E. Hammack, Karen M. Braas, Victor May

Part XII. Role of PACAP in Inflammatory Processes

38. PACAP Modulation of CNS and Peripheral Inflammation
Yukio Ago, Michael C. Condro, Abha K. Rajbhandari, Christina Van, Bhavaani Jayaram, Victor May, James A. Waschek

39. PACAP Regulation of Inflammatory and Free Radical Networks in Neuronal and Nonneuronal Diseases
Hirokazu Ohtaki, Seiji Shioda

40. Immunobiology of the Pituitary Adenylate Cyclase-Activating Peptide
Mario Delgado

Part XIII. PACAP in Stress and Mood Disorders

41. PACAPergic Synaptic Signaling and Circuitry Mediating Mammalian Responses to Psychogenic and Systemic Stressors
Sunny Z. Jiang, Lee E. Eiden

42. Using PACAP Heterozygous Mice as Models of the Three Hit Theory of Depression
Jozsef Farkas, Laszlo A. Kovacs, Tamas Gaszner, Balazs Gaszner

43. PACAP and Depression
Albert Pinhasov, Izhak Michaelevski, Igor Koman, Elimelech Nesher

44. Implications of PACAP Signaling in Psychiatric Disorders
Hitoshi Hashimoto, Norihito Shintani, Yukio Ago, Atsuko Hayata-Takano, Takanobu Nakazawa, Ryota Hashimoto, Shinsuke Matsuzaki, Taiichi Katayama, Masaya Tohyama, Toshio Matsuda, Akemichi Baba

45. Mechanisms of PACAP in PTSD and Stress-Related Disorders in Humans
Lauren A. M. Lebois, Kerry J. Ressler

46. PACAP, VIP, and ADNP: Autism and Schizophrenia
Illana Gozes

Part XIV. Clinical Relations of PACAP

47. PACAP and Cancer
Terry W. Moody, Robert T. Jensen

48. PACAP as a Potential Biomarker: Alterations of PACAP Levels in Human Physiological and Pathological Conditions
Dora Reglodi, Zsuzsanna Helyes, Jozsef Nemeth, Reka A. Vass, Andrea Tamas

49. Examination of PACAP During Lactation
Andrea Tamas, Reka A. Vass, Zsuzsanna Helyes, Katalin Csanaky, Zalan Szanto, Jozsef Nemeth, Dora Reglodi

Keywords: Biomedicine, Neurosciences