PI3K-mTOR in Cancer and Cancer Therapy

1. PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics
Sameer S. Chopra, Lewis C. Cantley

Part I. PI3K-mTOR Pathway in Cancers

2. The mTOR Complexes in Cancer Cell Metabolism
Thomas Lynch, Joseph G. Moloughney, Estela Jacinto

3. PI3K-AKT-mTOR Pathway Cooperates with the DNA Damage Repair Pathway: Carcinogenesis in Triple-Negative Breast Cancers and Beyond
Pradip De, Jennifer H. Carlson, Brian Leyland-Jones, Nandini Dey

4. The AKT-mTOR Signaling Pathway for Drug Response Prediction and Prognostic Signatures
John Conor Moran, Elisa Baldelli, Emanuel F. Petricoin, Mariaelena Pierobon

5. Resistance to PI3K Pathway Inhibition
Payal D. Shah, Sarat Chandarlapaty

Part II. PI3K-mTOR Pathway in Cancer Medicine

6. Combination Therapies Targeting the PI3K/AKT/mTOR Pathways
Aung Naing, Gordon B Mills, Funda Meric-Bernstam

7. Phospho-Inositol-3-Kinase Activity and Dysregulation in Pediatric Leukemia and Lymphoma
Charles B Goodwin, Rebecca J. Chan

8. HER2 Signaling Network in Advanced Breast Cancer: Opportunities for Combination Therapies
Nandini Dey, Brian Leyland-Jones, Pradip De

9. The PI3K-mTOR Pathway in Prostate Cancer: Biological Significance and Therapeutic Opportunities
Jason Boyang Wu, Leland W.K. Chung

Keywords: Biomedicine, Cancer Research, Molecular Medicine, Drug Resistance