Crohn's Disease and Ulcerative Colitis

Part I. Epidemiology

1. Environmental Factors in the Epidemiology of Inflammatory Bowel Disease
Morten H. Vatn

Part II. Immunobiology

2. Role of the Intestinal Immune System in Health
Per Brandtzaeg

3. Understanding the Epithelial Barrier in IBD
Matthew A. Odenwald, Jerrold R. Turner

4. Intestinal Microbiology and Ecology in Crohn’s Disease and Ulcerative Colitis
Ludovica F. Buttó, Dirk Haller

5. The Immune System in IBD: Antimicrobial Peptides
Charles L. Bevins

6. Vascular Responses to Intestinal Inflammation
D. Neil Granger, Norman R. Harris

7. Immunobiology of Human Dendritic Cells in Inflammatory Bowel Disease
Daniel C. Baumgart

8. Immunobiology of T-Cells in Inflammatory Bowel Disease
S. Snapper, D. Nguyen, A. Biswas

9. Immunobiology of B Cells in Inflammatory Bowel Disease
Atsushi Mizoguchi, Atul K. Bhan

10. Immune Cells: Monocytes and Macrophages
Gerhard Rogler

11. Immune Functions of Epithelial Cells in Inflammatory Bowel Disease
Eric L. Campbell, Sean P. Colgan

12. Autophagy and Endoplasmic Reticulum Stress
Arthur Kaser

13. Matrix Metalloproteinases
Paolo Biancheri, Thomas T. MacDonald

14. Paradigm of T Cell Differentiation in IBD
Takashi Nagaishi, Mamoru Watanabe

15. Mouse Models of Chronic Intestinal Inflammation: Characterization and Use in Pharmacological Intervention Studies
Cynthia Reinoso Webb, Matthew B. Grisham

16. Stem Cells and Organoids to Study Epithelial Cell Biology in IBD
Jorge O. Múnera, James M. Wells

Part III. Diagnostic Approach

17. Enhanced Endoscopy
R. Kiesslich

18. Magnetic Resonance Enterography
Patrik Rogalla, Luís Guimarães

19. Computed Tomography Enterography and Inflammatory Bowel Disease
J. G. Fletcher

20. Ultrasound in Inflammatory Bowel Disease
A. Potthoff, C. Agné, M. Gebel

21. Laboratory Evaluation, Including Novel Diagnostic Markers
M. Flamant, X. Roblin

22. Pathology of Inflammatory Bowel Disease
Nora E. Joseph, Christopher R. Weber

23. Objective Assessment of Clinical Disease Activity
Edouard Louis, Catherine Kemseke, Catherine Reenaers

24. Objective Assessment of Endoscopic Disease Activity and Mucosal Healing
Britt Christensen, David T. Rubin

25. Evaluation of Quality of Life in Crohn’s Disease and Ulcerative Colitis: What Is Health-Related Quality of Life?
Katrine Carlsen, Pia Munkholm, Johan Burisch

26. Evaluation of Health Economics in Inflammatory Bowel Disease
Reena Khanna, Brian G. Feagan

Part IV. Therapy: Crohn’s Disease

27. The Natural History of Inflammatory Bowel Disease
Charles N. Bernstein

28. Conventional Medical Management of Crohn’s Disease: Sulfasalazine
Miquel A. Gassull, Eduard Cabré

29. Steroid Therapy for Crohn’s Disease
A. Hillary Steinhart

30. Thiopurines in Crohn’s Disease
Adi Lahat, Rami Eliakim

31. Conventional Medical Management of Crohn’s Disease: Methotrexate
Grace Harkin, Laurence Egan

32. Adalimumab for the Treatment of Crohn’s Disease
Remo Panaccione

33. Biologic Therapy of Crohn’s Disease: Certolizumab
Alessandro Armuzzi, Daniela Pugliese

34. Biologic Therapy for Crohn’s Disease: Infliximab
Jan-Michael A. Klapproth, Gary R. Lichtenstein

35. Briakinumab and Ustekinumab: Anti-p40 Antibodies for Inflammatory Bowel Disease Treatment
Peter Mannon

36. Biological Therapy of Crohn’s Disease: Natalizumab, Vedolizumab, and Anti-MadCAM
Pieter Hindryckx, Geert D’Haens

37. Optimal Management of Fistulizing Crohn’s Disease
Farhad Peerani, Bruce E. Sands

Part V. Therapy: Ulcerative Colitis

38. Sulfasalazine and 5-Aminosalicylates for Ulcerative Colitis
Reena Khanna, John K. Marshall

39. Conventional Therapy of Ulcerative Colitis: Corticosteroids
Kirstin Taylor, Peter R. Gibson

40. Medical Management of Ulcerative Colitis: Conventional Therapy—Azathioprine
Barrett G. Levesque, Edward V. Loftus

41. Calcineurin Inhibitors in Ulcerative Colitis
Andreas Fischer, Daniel C. Baumgart

42. Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: Infliximab
Mindy Lam, Brian Bressler

43. Biologic Therapy of Ulcerative Colitis: Adalimumab
Walter Reinisch

44. Biologic Therapy of Ulcerative Colitis: Golimumab
Mark A. Samaan, Peter M. Irving

45. Biologic Therapy of Ulcerative Colitis: Natalizumab, Vedolizumab, Etrolizumab (rHUMab Beta 7), Anti-MAdCAM
Severine Vermeire

46. Probiotics, Prebiotics, and Antibiotics in IBD
Paolo Gionchetti, Carlo Calabrese, Andrea Calafiore, Fernando Rizzello

47. Biosimilars in the Treatment of Inflammatory Bowel Disease
Vivian W. Huang, Richard N. Fedorak

48. Step-Up vs. Top-Down Approach in Crohn’s Disease
Christine Y. Yu, Daniel W. Hommes

49. Leukocytapheresis Therapy of Inflammatory Bowel Disease
Takanori Kanai

50. Surgical Management of Crohn’s Disease and Ulcerative Colitis
Robert R. Cima, John H. Pemberton

Part VI. Extraintestinal Manifestations

51. Extraintestinal Manifestations: Autoimmune Hepatitis
Michael P. Manns, Nora Schweitzer

52. Primary Sclerosing Cholangitis
Roger W. Chapman, Kate D. Williamson

53. Autoimmune Pancreatitis and Other Organ Involvement
Go Kuwata, Terumi Kamisawa

54. Cutaneous and Oral Manifestations of Inflammatory Bowel Disease
Caroline P. Allen, Susan M. Burge

55. Arthritis, Arthropathy, and Osteoporosis in Inflammatory Bowel Disease
Alistair Tindell, Hanna Johnsson, Iain B. McInnes

Part VII. Nutrition

56. Nutrition in Inflammatory Bowel Disease
Alan L. Buchman

Part VIII. Pregnancy, Family Planning and Pediatric Aspects

57. Pregnancy and Fertility in Inflammatory Bowel Disease
Rebecca Matro, Uma Mahadevan

58. Pediatric Aspects of Inflammatory Bowel Disease
Brendan Boyle, Jeffrey S. Hyams

Part IX. Surveillance and Prevention

59. Management and Prevention of Infectious Diseases in IBD Patients
Kristine Macartney, Nigel Crawford

60. Incidence of Cancer and Screening in Inflammatory Bowel Disease
Jimmy K. Limdi, Francis A. Farraye

61. Inflammatory Bowel Diseases: How to Identify High-Risk Patients
Jacques Cosnes, Harry Sokol

Part X. Patient Perspective and Resources

62. Patient Perspective on Inflammatory Bowel Disease
Ayesha Williams, Marjorie Merrick

63. Patient Resources in Inflammatory Bowel Disease
Sanna Lönnfors, Marco Greco

Keywords: Medicine & Public Health, Gastroenterology