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Brannath, Werner

Group Sequential and Confirmatory Adaptive Designs in Clinical Trials

Brannath, Werner - Group Sequential and Confirmatory Adaptive Designs in Clinical Trials, ebook

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ISBN: 9783319325620
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Table of contents

Part I. Group Sequential Designs

1. Repeated Significance Tests
Gernot Wassmer, Werner Brannath

2. Procedures with Equally Sized Stages
Gernot Wassmer, Werner Brannath

3. Procedures with Unequally Sized Stages
Gernot Wassmer, Werner Brannath

4. Confidence Intervals, p-Values, and Point Estimation
Gernot Wassmer, Werner Brannath

5. Applications
Gernot Wassmer, Werner Brannath

Part II. Confirmatory Adaptive Designs with a Single Hypothesis

6. Adaptive Group Sequential Tests
Gernot Wassmer, Werner Brannath

7. Decision Tools for Adaptive Designs
Gernot Wassmer, Werner Brannath

8. Estimation and p-Values for Two-Stage Adaptive Designs
Gernot Wassmer, Werner Brannath

9. Adaptive Designs with Survival Data
Gernot Wassmer, Werner Brannath

Part III. Adaptive Designs with Multiple Hypotheses

10. Multiple Testing in Adaptive Designs
Gernot Wassmer, Werner Brannath

11. Applications and Case Studies
Gernot Wassmer, Werner Brannath

Keywords: Statistics, Statistics for Life Sciences, Medicine, Health Sciences, Biostatistics, Drug Safety and Pharmacovigilance, Pharmaceutical Sciences/Technology

Author(s)
 
Publisher
Springer
Publication year
2016
Language
en
Edition
1
Series
Springer Series in Pharmaceutical Statistics
Category
Natural Sciences
Format
Ebook
eISBN (PDF)
9783319325620
Printed ISBN
978-3-319-32560-6

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