Redox-Active Therapeutics

1. Superoxide and the Superoxide Dismutases: An Introduction by Irwin Fridovich
Irwin Fridovich

2. The Discovery of Superoxide Dismutase and Its Role in Redox Biology
Joe M. McCord

3. Manganese Superoxide Dismutase (MnSOD) and Its Importance in Mitochondrial Function and Cancer
Aaron K. Holley, Daret K. St. Clair

4. Regulation of the Cellular Redox Environment by Superoxide Dismutases, Catalase, and Glutathione Peroxidases During Tumor Metastasis
L. P. Madhubhani P. Hemachandra, Akshaya Chandrasekaran, J. Andres Melendez, Nadine Hempel

5. Superoxide Dismutase Family of Enzymes in Brain Neurogenesis and Radioprotection
Huy Nguyen, Chandra Srinivasan, Ting-Ting Huang

6. Metabolic Production of H2O2 in Carcinogenesis and Cancer Treatment
Bryan G. Allen, Douglas R. Spitz

7. Mimicking SOD, Why and How: Bio-Inspired Manganese Complexes as SOD Mimic
Clotilde Policar

8. Mn Porphyrin-Based Redox-Active Therapeutics
Ines Batinić-Haberle, Artak Tovmasyan, Ivan Spasojević

9. Cytochrome P450-Like Biomimetic Oxidation Catalysts Based on Mn Porphyrins as Redox Modulators
Victor Hugo A. Pinto, Nathália K. S. M. Falcão, Jacqueline C. Bueno-Janice, Ivan Spasojević, Ines Batinić-Haberle, Júlio S. Rebouças

10. Nitrones as Potent Anticancer Therapeutics
Rheal A. Towner, Robert A. Floyd

11. Salen Manganese Complexes Mitigate Radiation Injury in Normal Tissues Through Modulation of Tissue Environment, Including Through Redox Mechanisms
Susan R. Doctrow, Brian Fish, Karl D. Huffman, Zelmira Lazarova, Meetha Medhora, Jacqueline P. Williams, John E. Moulder

12. Molecular Basis for Anticancer and Antiparasite Activities of Copper-Based Drugs
Ana Maria Da Costa Ferreira, Philippe Alexandre Divina Petersen, Helena Maria Petrilli, Maria Rosa Ciriolo

13. Small Signaling Molecules and CO-Releasing Molecules (CORMs) for the Modulation of the Cellular Redox Metabolism
Peter V. Simpson, Ulrich Schatzschneider

14. HNO/Thiol Biology as a Therapeutic Target
Jan Lj. Miljkovic, Milos R. Filipovic

15. Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents
Debashree Basudhar, Katrina M. Miranda, David A. Wink, Lisa A. Ridnour

16. Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells
Rebecca E. Oberley-Deegan, James D. Crapo

17. Targeted Therapy for Malignant Brain Tumors
Paula Lam, Nivedh Dinesh, Xandra O. Breakefield

18. Redox Therapeutics in Breast Cancer: Role of SOD Mimics
Ana S. Fernandes, Nuno Saraiva, Nuno G. Oliveira

19. Anticancer Action of Mn Porphyrins in Head and Neck Cancer
Kathleen A. Ashcraft, Mark W. Dewhirst

20. Redox-Based Therapeutic Strategies in the Treatment of Skin Cancers
Annapoorna Sreedhar, Ines Batinić-Haberle, Yunfeng Zhao

21. Role of Oxidative Stress in Erectile Dysfunction After Prostate Cancer Therapy
Timothy J. Robinson, Bridget F. Koontz

22. Theranostic Nanoconjugates of Tetrapyrrolic Macrocycles and Their Applications in Photodynamic Therapy
Jayeeta Bhaumik, Seema Kirar, Joydev K. Laha

23. Quantum Dots in Photodynamic Therapy
Osnir S. Viana, Martha S. Ribeiro, Adriana Fontes, Beate S. Santos

24. Metalloporphyrin in CNS Injuries
Huaxin Sheng, David S. Warner

25. The Contribution of Nitroxidative Stress to Pathophysiological Pain and Opioid Analgesic Failure
Ashley M. Symons-Liguori, Kali Janes, William L. Neumann, Daniela Salvemini

26. Amyotrophic Lateral Sclerosis: Present Understanding of the Role of SOD
Kristina Ramdial, Fabian H. Rossi, Maria Clara Franco, Alvaro G. Estevez

27. Redox Regulation and Misfolding of SOD1: Therapeutic Strategies for Amyotrophic Lateral Sclerosis
Wouter Hubens, Ayako Okado-Matsumoto

28. Redox-Based Therapeutics for Prevention, Mitigation, and Treatment of Lung Injury Secondary to Radiation Exposure
Isabel L. Jackson, Zeljko Vujaskovic

29. Using Metalloporphyrins to Preserve β Cell Mass and Inhibit Immune Responses in Diabetes
Gina M. Coudriet, Dana M. Previte, Jon D. Piganelli

30. Redox-Active Metal Complexes in Trypanosomatids
Cynthia Demicheli, Frédéric Frézard, Nicholas P. Farrell

31. Erratum to: Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents
Debashree Basudhar, Katrina M. Miranda, David A. Wink, Lisa A. Ridnour

Keywords: Life Sciences, Oxidative Stress, Enzymology, Cancer Research