Novel Immunotherapeutic Approaches to the Treatment of Cancer

1. Enhancing the Efficacy of Checkpoint Blockade Through Combination Therapies
Vikram R. Juneja, Martin W. LaFleur, Robert T. Manguso, Arlene H. Sharpe

2. Novel Immunomodulatory Pathways in the Immunoglobulin Superfamily
Paul D. Rennert

3. Parallel Costimulation of Effector and Regulatory T Cells by OX40, GITR, TNFRSF25, CD27, and CD137: Implications for Cancer Immunotherapy
Taylor H. Schreiber

4. NK Cell Responses in Immunotherapy: Novel Targets and Applications
Russell Pachynski, Holbrook Kohrt

5. Reversing T Cell Dysfunction for Tumor Immunotherapy
Lawrence P. Kane, Greg M. Delgoffe

6. Immunomodulation Within a Single Tumor Site to Induce Systemic Antitumor Immunity: In Situ Vaccination for Cancer
Linda Hammerich, Joshua D. Brody

7. Novel Targets and Their Assessment for Cancer Treatment
Sheila Ranganath, AnhCo Nguyen

8. The New Frontier of Antibody Drug Conjugates: Targets, Biology, Chemistry, Payloads
Christopher D. Thanos, Paul D. Rennert

9. Cellular Therapies: Gene Editing and Next-Gen CAR T Cells
Thomas J. Cradick

10. Targeting the Physicochemical, Cellular, and Immunosuppressive Properties of the Tumor Microenvironment by Depletion of Hyaluronan to Treat Cancer
Christopher D. Thanos

Keywords: Biomedicine, Immunology, Cancer Research, Oncology, Pharmacology/Toxicology