New Approaches to Drug Discovery

1. Trends in Modern Drug Discovery
Jörg Eder, Paul L. Herrling

2. Functional Genomics in Pharmaceutical Drug Discovery
Robert Adams, Michael Steckel, Barbara Nicke

3. Emerging Target Families: Intractable Targets
Stefan Knapp

4. In Vivo Target Validation Using Biological Molecules in Drug Development
Derek S. Sim, Katalin Kauser

5. High-Throughput Synthesis of Diverse Compound Collections for Lead Discovery and Optimization
C. Rademacher, P. H. Seeberger

6. Sources for Leads: Natural Products and Libraries
Eric F. Herwerden, Roderich D. Süssmuth

7. New Compound Classes: Protein–Protein Interactions
C. Ottmann

8. Using Cheminformatics in Drug Discovery
Michael S. Lawless, Marvin Waldman, Robert Fraczkiewicz, Robert D. Clark

9. Implementation and Use of State-of-the-Art, Cell-Based In Vitro Assays
Gernot Langer

10. Translational In Vivo Models for Women’s Health: The Nonhuman Primate Endometrium—A Predictive Model for Assessing Steroid Receptor Modulators
Ov Daniel Slayden

11. Predictive In Vivo Models for Oncology
Diana Behrens, Jana Rolff, Jens Hoffmann

12. Translational In Vivo Models for Cardiovascular Diseases
Daniela Fliegner, Christoph Gerdes, Jörg Meding, Johannes-Peter Stasch

13. Pharmacokinetics in Drug Discovery: An Exposure-Centred Approach to Optimising and Predicting Drug Efficacy and Safety
Andreas Reichel, Philip Lienau

14. Nonclinical Safety and Toxicology
Claudia Stark, Thomas Steger-Hartmann

15. Impact of Biomarkers on Personalized Medicine
Patricia Carrigan, Thomas Krahn

16. Modeling and Simulation of In Vivo Drug Effects
Jörg Lippert, Rolf Burghaus, Lars Kuepfer, Bart Ploeger, Stephan Schaller, Walter Schmitt, Stefan Willmann

Keywords: Biomedicine, Pharmacology/Toxicology, Drug Safety and Pharmacovigilance, Medical Biochemistry, Metabolomics