Radiobiology of Glioblastoma

1. Introduction and Background
Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano

Part I. From Bedside to Bench: Radiobiological Topics Arising from Clinical Studies

2. The “Radioresistance” of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options
Michela Buglione, Luca Triggiani, Paolo Borghetti, Sara Pedretti, Nadia Pasinetti, Stefano Maria Magrini

3. Radiobiological Hints from Clinical Studies
Silvia Scoccianti, Riccardo Santoni, Beatrice Detti, Gianluca Ingrosso, Daniela Greto, Giulio Francolini

4. Chemoradiotherapy: Radiation Total Dose and Fractionation
Silvia Chiesa, Mario Balducci, Milena Ferro, Anna Rita Alitto, Vincenzo Valentini

5. Clinical Evidence and Radiobiological Background of Particle Radiation Therapy
Walter Tinganelli, Marco Durante, Alexander Helm

6. Mathematical Modelling of Radiobiological Parameters
Piernicola Pedicini, Lidia Strigari, Luigi Spiazzi, Alba Fiorentino, Paolo Tini, Luigi Pirtoli

7. Clinical, Pathological, and Molecular Prognostic Parameters in Glioblastoma Patients Undergoing Chemo- and Radiotherapy
Paolo Tini, Clelia Miracco, Marzia Toscano, Silvia Palumbo, Sergio Comincini, Giovanni Luca Gravina, Luigi Pirtoli

8. Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond
Francesca Felice, Vincenzo Tombolini, Michela Buglione, Daniela Musio, Luca Triggiani, Stefano Maria Magrini

Part II. Preclinical Research

9. Basic Knowledge of Glioblastoma Radiobiology
Monica Mangoni, Mariangela Sottili, Chiara Gerini, Lorenzo Livi

10. The Immune System and Its Contribution to the Radiotherapeutic Response of Glioblastoma
Benjamin Cooper, Ralph Vatner, Encouse Golden, Joshua Silverman, Silvia Formenti

11. Genetic and Epigenetic Determinants in Tumor Initiation and Progression of Glioblastoma
A. Cimini, A. Fidoamore, M. d’Angelo, A. Antonosante, L. Cristiano, E. Benedetti, Antonio Giordano

12. Tumor Microenvironment, Hypoxia, and Stem Cell-Related Radiation Resistance
Mariangela Sottili, Chiara Gerini, Isacco Desideri, Mauro Loi, Lorenzo Livi, Monica Mangoni

13. Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide
Marzia Toscano, Silvia Palumbo, Paolo Tini, Clelia Miracco, Giovanni Luca Gravina, Sergio Comincini

14. miRNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models
Silvia Palumbo, G. Belmonte, Paolo Tini, Marzia Toscano, Clelia Miracco, Sergio Comincini

15. NanoMaterials Technology for Research Radiobiology
Elisa Panzarini, Luciana Dini

Part III. From Bench to Bedside: Translational Perspectives

16. Preclinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods
Anita Tandle, Uma Shankavaram, Cody Schlaff, Kevin Camphausen, Andra Krauze

17. From Molecular to Clinical Radiation Biology of Glioblastoma
Nadia Pasinetti, Luigi Pirtoli, Michela Buglione, Luca Triggiani, Paolo Borghetti, Paolo Tini, Stefano Maria Magrini

18. Perspective of the Large Databases and Ontologic Models of Creation of Preclinical and Clinical Results
Elisa Meldolesi, Mario Balducci, Silvia Chiesa, Andrea Damiani, Nicola Dinapoli, Roberto Gatta, Vincenzo Valentini

19. Concluding Remarks and Perspectives for Future Research
Antonio Giordano, Giovanni Luca Gravina, Luigi Pirtoli

Keywords: Medicine & Public Health, Pathology, Oncology