The Value of Systems and Complexity Sciences for Healthcare

Part I. Complexity in Clinical Care

1. “Returning to Holism”: An Imperative for the Twenty-First Century
Joachim P. Sturmberg

2. Systems Biology: Unravelling Molecular Complexity in Health and Disease
Amrita K. Cheema, Massimo S. Fiandaca, Mark Mapstone, Howard J. Federoff

3. Complicated vs. Complex, Disease vs. Illness: Rethinking Diagnosis, Therapy, and Restoring Health
S. Lee Hong, Simeon J. Hain

4. A System for Systems Epidemiology: The Example of Inference from Agent-Based Models
Abdulrahman M. El-Sayed

5. Coping with Complexity and Uncertainty: Insights from Studying Epidemiology in Family Medicine
Martin Konitzer, Waltraud Fink, Vilen Lipatov, Gustav Kamenski, Thorsten Knigge

6. Anticipation in Complex Systems: Potential Implications for Improving Safety and Quality in Healthcare
Thomas O. Staiger

7. Extreme Variability is Typical Not Normal
Bruce J. West

8. Monitoring Variability and Complexity at the Bedside
Andrew J. E. Seely, Kimberley D. Newman, Christophe Herry

9. Heterogeneity Mediated System Complexity: The Ultimate Challenge for Studying Common and Complex Diseases
Henry H. Heng, Steven D. Horne, Joshua B. Stevens, Batoul Y. Abdallah, Guo Liu, Saroj K. Chowdhury, Steven W. Bremer, Kezhong Zhang, Christine J. Ye

10. Multimorbidity: Through a Glass Darkly
Carmel M. Martin

11. Viewing Mental Health Through the Lens of Complexity Science
David A. Katerndahl

12. Quantitatively Demonstrating the Complex Nature of Intimate Partner Violence
David A. Katerndahl, Sandra Burge, Robert Ferrer, Johanna Becho, Robert Wood

13. Depression: Not Just a Top–Down Phenomenon
Jeanette M. Bennett, Joachim P. Sturmberg

Part II. Complexity and the Healthcare System Ethics, Organisation Policy, and Politics

14. Ethical Complexities in Systems Healthcare: What Care and for Whom?
Kevin T. FitzGerald

15. Systematic Reviews: Beyond Cochrane to Complexity
Frances Griffiths, Jane Goudge

16. Agent-Based Modelling of Organizational Performance
Russell S. Gonnering, David Logan

17. Leading the Emergency Department as a Complex Adaptive System
Paola Camorlinga, Sergio Camorlinga

18. The Value of Systems and Complexity Thinking to Enable Change in Adaptive Healthcare Organisations, Supported by Informatics
Beverley S. Ellis

19. Using a Team Approach to Address Avoidable Emergency Department Utilization and Re-hospitalizations as Symptoms of Complexity Through Quality Improvement Methodology
Jacqueline Morse, Andrew S. Valeras, Dominic Geffken, Daniel Eubank, A. John Orzano, Douglas Dreffer, Amanda DeCook, Aimee Burke Valeras

20. Access to Primary Care: A Complex Adaptive Systems Lens on Acuity
Carmel M. Martin, David Emanuel Surate Solaligue

21. “If the Facts Don’t Fit the Theory, Change the Theory”: Implications for Health System Reform
Joachim P. Sturmberg

Keywords: Medicine & Public Health, Health Administration, Health Care Management, Primary Care Medicine