Applications of Mass Spectrometry in Microbiology

1. Introduction
Plamen Demirev, Todd R. Sandrin

Part I. Methodology and Techniques

2. Methods and Instrumentation in Mass Spectrometry for the Differentiation of Closely Related Microorganisms
Franco Basile, Rudolph K. Mignon

3. Sample Preparation Methods for the Rapid MS Analysis of Microorganisms
Shobha Devi, Anren Hu, Yen-Peng Ho

4. Advantages Offered by Proteomic Strategies for Rapid Biodetection
Catherine Fenselau

5. Bottom-Up Proteomics Methods for Strain-Level Typing and Identification of Bacteria
Jacek P. Dworzanski

6. Maximizing the Taxonomic Resolution of MALDI-TOF-MS-Based Approaches to Bacterial Characterization: From Culture Conditions Through Data Analysis
Lin Zhang, Todd R. Sandrin

Part II. Subspecies Discrimination

7. Modulation of the Discriminatory Power of MALDI-TOF MS Profiling for Distinguishing Between Closely Related Bacterial Strains
Ondrej Šedo, Zbyněk Zdráhal

8. Discriminatory Power of MALDI-TOF Mass Spectrometry for Phylogenetically Closely Related Microbial Strains
Peter Lasch, Daniela Jacob, Silke R. Klee, Guido Werner

9. MALDI-TOF MS as a Novel Tool for Dereplication and Characterization of Microbiota in Bacterial Diversity Studies
Freek Spitaels, Anneleen D. Wieme, Peter Vandamme

10. Bacterial Identification at the Serovar Level by Top-Down Mass Spectrometry
Melinda A. McFarland, Denis Andrzejewski, John H. Callahan

Part III. Drug Resistance Monitoring and Assays

11. Rapid Profiling of Human Pathogenic Bacteria and Antibiotic Resistance Employing Specific Tryptic Peptides as Biomarkers
David Drissner, René Brunisholz, Ralph Schlapbach, Maria-Theresia Gekenidis

12. Detection of β-Lactamases and Their Activity Using MALDI-TOF MS
Jaroslav Hrabak, Vladimír Havlicek, Costas C. Papagiannitsis

13. Stable-Isotope-Based Strategies for Rapid Determination of Drug Resistance by Mass Spectrometry
Plamen Demirev

Keywords: Chemistry, Mass Spectrometry, Applied Microbiology, Epidemiology, Drug Resistance