The Initiation of DNA Replication in Eukaryotes

1. Introduction to Eukaryotic DNA Replication Initiation
Nalini Dhingra, Daniel L. Kaplan

2. Choice of Origins and Replication Timing Control in Budding Yeast
Arturo Calzada

3. Epigenetic vs. Sequence-Dependent Control of Eukaryotic Replication Timing
Kyle N. Klein, David M. Gilbert

4. Up and Down the Slope: Replication Timing and Fork Directionality Gradients in Eukaryotic Genomes
Olivier Hyrien

5. Chromatin Determinants of Origin Selection and Activation
Mónica P. Gutiérrez, David M. MacAlpine

6. Global and Local Regulation of Replication Origin Activity
Conrad A. Nieduszynski

7. Sequence Determinants of Yeast Replication Origins
M. K. Raghuraman, Ivan Liachko

8. Rif1, a Conserved Chromatin Factor Regulating DNA Replication, DNA Repair, and Transcription
Naoko Yoshizawa-Sugata, Satoshi Yamazaki, Hisao Masai

9. The Origin Recognition Complex in the Initiation of DNA Replication
Timothy Hoggard, Catherine A. Fox

10. Licensing of Replication Origins
Alberto Riera, Christian Speck

11. Coordination of DNA Replication and Histone Synthesis During S Phase
Johanna Paik, Serena Giovinazzi, Akash Gunjan

12. The Role of Mcm2–7 in Replication Initiation
Dirk Remus

13. Role of CDK in Replication Initiation
Seiji Tanaka, Hiroyuki Araki

14. Role of DDK in Replication Initiation
Daniel Rossbach, Robert A. Sclafani

15. Roles of Sld2, Sld3, and Dpb11 in Replication Initiation
Karl-Uwe Reußwig, Dominik Boos, Boris Pfander

16. The Role of Mcm10 in Replication Initiation
Ryan M. Baxley, Yee Mon Thu, Anja-Katrin Bielinsky

17. Role of Small-Molecule Modifiers in Replication Initiation
Giacomo Piccoli, Agnieszka Gambus

18. Role of Posttranslational Modifications in Replication Initiation
Lei Wei, Xiaolan Zhao

19. Assembly of the Cdc45-MCM2-7-GINS Complex, the Replication Helicase
Helmut Pospiech, Anna Szambowska

20. Structure and Activity of the Cdc45-Mcm2–7-GINS (CMG) Complex, the Replication Helicase
Barbara Medagli, Patrizia Crescenzio, Matteo March, Silvia Onesti

21. Structure and Function Studies of Replication Initiation Factors
Jingchuan Sun, Zuanning Yuan, Bruce Stillman, Christian Speck, Huilin Li

22. Regulation of the Initiation of DNA Replication upon DNA Damage in Eukaryotes
Kerstin Köhler, Pedro Ferreira, Boris Pfander, Dominik Boos

23. Protein Phosphatases and DNA Replication Initiation
Michael J. R. Stark, Shin-ichiro Hiraga, Anne D. Donaldson

24. DNA Replication Checkpoint Signaling
Nanda Kumar Sasi, Michael Weinreich

25. Meier-Gorlin Syndrome
Manzar Hossain, Bruce Stillman

26. Mechanisms and Consequences of Break-Induced Replication
Roberto A. Donnianni, Lorraine S. Symington

Keywords: Biomedicine, Human Genetics, Systems Biology, Microbial Genetics and Genomics