Anderson, Robert E.

Retinal Degenerative Diseases

Anderson, Robert E. - Retinal Degenerative Diseases, ebook


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Table of contents

Part I. Age-Related Macular Degeneration (AMD)

1. Apolipoprotein E Isoforms and AMD
Kimberly A Toops, Li Xuan Tan, Aparna Lakkaraju

2. Role of Chemokines in Shaping Macrophage Activity in AMD
Matt Rutar, Jan M Provis

3. Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD)
Lei Wang, Katayoon B Ebrahimi, Michelle Chyn, Marisol Cano, James T Handa

4. Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?
Elod Kortvely, Marius Ueffing

5. Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration
Manas R Biswal, Cristhian J Ildefonso, Haoyu Mao, Soo Jung Seo, Zhaoyang Wang, Hong Li, Yun Z. Le, Alfred S. Lewin

6. Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration
Andre K. Berner, Mark E. Kleinman

7. A Brief Discussion on Lipid Activated Nuclear Receptors and their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD)
Mayur Choudhary, Goldis Malek

8. Extracellular Matrix Alterations and Deposit Formation in AMD
Rosario Fernandez-Godino, Eric A. Pierce, Donita L. Garland

9. The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration
Cristhian J. Ildefonso, Manas R. Biswal, Chulbul M. Ahmed, Alfred S. Lewin

10. Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration
Mandy L. Lambros, Scott M. Plafker

11. Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease
Wenxin Ma, Wai T. Wong

12. VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration
Alexander G. Marneros

13. Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration
Luciana M. Pujol-Lereis, Nicole Schäfer, Laura B. Kuhn, Bärbel Rohrer, Diana Pauly

14. Gene-Diet Interactions in Age-Related Macular Degeneration
Sheldon Rowan, Allen Taylor

15. Challenges in the Development of Therapy for Dry Age-Related Macular Degeneration
Cynthia X. Wei, Aixu Sun, Ying Yu, Qianyong Liu, Yue-Qing Tan, Isamu Tachibana, Hong Zeng, Ji-Ye Wei

16. Nanoceria: a Potential Therapeutic for Dry AMD
Xue Cai, James F. McGinnis

17. β-amyloidopathy in the Pathogenesis of Age-Related Macular Degeneration in Correlation with Neurodegenerative Diseases
Victor V. Ermilov, Alla A. Nesterova

Part II. Macular Dystrophies/Inherited Macular Degeneration

18. Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans
Martin-Paul Agbaga

19. Mouse Models of Stargardt 3 Dominant Macular Degeneration
Peter Barabas, Aruna Gorusupudi, Paul S Bernstein, David Krizaj

20. Current Progress in Deciphering Importance of VLC-PUFA in the Retina
Lea D. Bennett, Robert E. Anderson

21. Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-Related Macular Degeneration and Potential Therapies
John D. Hulleman

Part III. Inherited Retinal Degenerations

22. Hsp90 as a Potential Therapeutic Target in Retinal Disease
Mònica Aguilà, Michael E. Cheetham

23. Leber Congenital Amaurosis: Genotypes and Retinal Structure Phenotypes
Samuel G. Jacobson, Artur V. Cideciyan, Wei Chieh Huang, Alexander Sumaroka, Hyun Ju Nam, Rebecca Sheplock, Sharon B. Schwartz

24. A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects
Jeremy R. Charette, Ivy S. Samuels, Minzhong Yu, Lisa Stone, Wanda Hicks, Lan Ying Shi, Mark P. Krebs, Jürgen K. Naggert, Patsy M. Nishina, Neal S. Peachey

25. Ablation of Chop Transiently Enhances Photoreceptor Survival but Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin
Wei-Chieh Chiang, Victory Joseph, Douglas Yasumura, Michael T. Matthes, Alfred S. Lewin, Marina S. Gorbatyuk, Kelly Ahern, Matthew M. LaVail, Jonathan H. Lin

26. Identification of a Novel Gene on 10q22.1 Causing Autosomal Dominant Retinitis Pigmentosa (adRP)
Stephen P. Daiger, Lori S. Sullivan, Sara J. Bowne, Daniel C. Koboldt, Susan H. Blanton, Dianna K. Wheaton, Cheryl E. Avery, Elizabeth D. Cadena, Robert K. Koenekoop, Robert S. Fulton, Richard K. Wilson, George M. Weinstock, Richard A. Lewis, David G. Birch

FAM161A and TTC8 are Differentially Expressed in Non-Allelelic Early Onset Retinal Degeneration
Louise M Downs, Gustavo D Aguirre

28. Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization
Joseph Fogerty, Kristin Denton, Brian D. Perkins

29. RDS Functional Domains and Dysfunction in Disease
Michael W. Stuck, Shannon M. Conley, Muna I. Naash

TULP1 Missense Mutations Induces the Endoplasmic Reticulum Unfolded Protein Response Stress Complex (ER-UPR)
Glenn P. Lobo, Lindsey A. Ebke, Adrian Au, Stephanie A. Hagstrom

31. Understanding Cone Photoreceptor Cell Death in Achromatopsia
Livia S. Carvalho, Luk H. Vandenberghe

32. Geranylgeranylacetone Suppresses N-Methyl-N-nitrosourea-Induced Photoreceptor Cell Loss in Mice
Yoshiki Koriyama, Kazuhiro Ogai, Kayo Sugitani, Suguru Hisano, Satoru Kato

33. My Retina Tracker: An On-line International Registry for People Affected with Inherited Orphan Retinal Degenerative Diseases and their Genetic Relatives - A New Resource
Joan K. Fisher, Russell L. Bromley, Brian C. Mansfield

34. A Mini-review: Animal Models of GUCY2D Leber Congenital Amaurosis (LCA1)
Shannon E. Boye

35. A Comprehensive Review of Mutations in the MERTK Proto-Oncogene
Célia Parinot, Emeline F. Nandrot

Part IV. In Vivo Imaging and Other Diagnostic Advances

36. New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo

Marie E. Burns, Emily S. Levine, Eric B. Miller, Azhar Zam, Pengfei Zhang, Robert J. Zawadzki, Edward N. Pugh

37. Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia
Mortada A. Abozaid, Christopher S. Langlo, Adam M. Dubis, Michel Michaelides, Sergey Tarima, Joseph Carroll

38. Quantitative Fundus Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is not Increased in Non-Lesion Areas of Retina
Janet R. Sparrow, Tobias Duncker, Russell Woods, François C. Delori

39. Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa

Michael J. Gale, Shu Feng, Hope E. Titus, Travis B. Smith, Mark E. Pennesi

40. Intra-familial Similarity of Wide-Field Fundus Autofluorescence in Inherited Retinal Dystrophy
Yuka Furutani, Ken Ogino, Akio Oishi, Norimoto Gotoh, Yukiko Makiyama, Maho Oishi, Masafumi Kurimoto, Nagahisa Yoshimura

41. Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy
Akio Oishi, Maho Oishi, Ken Ogino, Satoshi Morooka, Nagahisa Yoshimura

42. The Development of a Cat Model of Retinal Detachment and Re-attachment
Sarah Wassmer, Brian C. Leonard, Stuart G. Coupland, Adam Baker, John Hamilton, Renée Torlone, David N. Zacks, Catherine Tsilfidis

Part V. Mechanisms of Degeneration

43. The Role of X-Chromosome Inactivation in Retinal Development and Disease
Abigail T. Fahim, Stephen P. Daiger

44. A Non-Canonical Role for β-Secretase in the Retina
Qingwen Qian, Sayak K. Mitter, S. Louise Pay, Xiaoping Qi, Catherine Bowes Rickman, Maria B. Grant, Michael E Boulton

45. The Consequences of Hypomorphic RPE65 for Rod and Cone Photoreceptors
Marijana Samardzija, Maya Barben, Philipp Geiger, Christian Grimm

46. The Rate of Vitamin A Dimerization in Lipofuscinogenesis, Fundus Autofluorescence, Retinal Senescence and Degeneration
Ilyas Washington, Leonide Saad

47. Can Vitamin A be Improved to Prevent Blindness due to Age-Related Macular Degeneration, Stargardt Disease and Other Retinal Dystrophies?
Leonide Saad, Ilyas Washington

48. Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina
Seifollah Azadi, Richard S. Brush, Robert E. Anderson, Raju V.S. Rajala

49. Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic Targets
Yvan Arsenijevic

50. Nitric Oxide Synthase Activation as a Trigger of N-methyl-N-nitrosourea-Induced Photoreceptor Cell Death
Suguru Hisano, Yoshiki Koriyama, Kazuhiro Ogai, Kayo Sugitani, Satoru Kato

51. Molecular Principles for Decoding Homeostasis Disruptions in the Retinal Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseases
Nicolas G. Bazan

52. Aging and Vision
Marcel V. Alavi

Part VI. Neuroprotection, Small Molecules and Related Therapeutic Approaches

53. The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair
Carolina Abrahan, John D. Ash

54. Retinal Caveolin-1 Modulates Neuroprotective Signaling
Alaina Reagan, Xiaowu Gu, Stefanie M. Hauck, John D. Ash, Guangwen Cao, Timothy C. Thompson, Michael H. Elliott

55. Photoreceptor Neuroprotection: Regulation of Akt Activation Through Serine/Threonine Phosphatases, PHLPP and PHLPPL
Raju V.S. Rajala, Yogita Kanan, Robert E. Anderson

56. The Role of AMPK Pathway in Neuroprotection
Lei Xu, John D. Ash

57. Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice
Eric C. Lawson, Shagun K. Bhatia, Moon K. Han, Moe H. Aung, Vincent Ciavatta, Jeffrey H. Boatright, Machelle T. Pardue

58. Near-Infrared Photobiomodulation in Retinal Injury and Disease
Janis T. Eells, Sandeep Gopalakrishnan, Krisztina Valter

59. Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns
Micah A. Chrenek, Jana T. Sellers, Eric C. Lawson, Priscila P. Cunha, Jessica L. Johnson, Preston E. Girardot, Cristina Kendall, Moon K. Han, Adam Hanif, Vincent T. Ciavatta, Marissa A. Gogniat, John M. Nickerson, Machelle T. Pardue, Jeffrey H. Boatright

60. Small Molecules that Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models
Craig Beeson, Chris Lindsey, Cecile Nasarre, Mausumi Bandyopadhyay, Nathan Perron, Bärbel Rohrer

61. Histone Deacetylase: Therapeutic Targets in Retinal Degeneration
Conor Daly, Jun Yin, Breandán N. Kennedy

62. Therapeutic Approach of Nanotechnology for Oxidative Stress Induced Ocular Neurodegenerative Diseases
Rajendra N. Mitra, Shannon M. Conley, Muna I. Naash

63. Transscleral Controlled Delivery of Geranylgeranylaceton Using a Polymeric Device Protects Rat Retina Against Light Injury
Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe

64. Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa
David A. Parfitt, Michael E. Cheetham

Part VII. Gene Therapy and Antisense

65. Gene Therapy for MERTK-Associated Retinal Degenerations
Matthew M. LaVail, Douglas Yasumura, Michael T. Matthes, Haidong Yang, William W. Hauswirth, Wen-Tao Deng, Douglas Vollrath

66. Tamoxifen-Containing Eye Drops Successfully Trigger Cre-Mediated Recombination in the Entire Eye
Anja Schlecht, Sarah V. Leimbeck, Ernst R. Tamm, Barbara M. Braunger

67. Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages
Wenjun Xiong, Constance Cepko

68. Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin Mutation
Shannon M. Conley, Patrick Whalen, Alfred S. Lewin, Muna I. Naash

69. Antisense Oligonucleotide Therapy for Inherited Retinal Dystrophies
Xavier Gerard, Alejandro Garanto, Jean-Michel Rozet, Rob W. J. Collin

70. Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins
Minghao Jin, Songhua Li, Jane Hu, Heather H. Jin, Samuel G. Jacobson, Dean Bok

71. Evaluation of Ocular Gene Therapy in an Italian Patient Affected by Congenital Leber Amaurosis Type 2 Treated in Both Eyes
Francesco Testa, Albert M Maguire, Settimio Rossi, Kathleen Marshall, Alberto Auricchio, Paolo Melillo, Jean Bennett, Francesca Simonelli

Part VIII. Stem Cells and Cell-Based Therapies

72. Regenerative Medicine: Solution in Sight
Qingjie Wang, Jeffrey H. Stern, Sally Temple

73. Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-Derived Retinal Pigment Epithelium Cells
Yao Li, Lawrence Chan, Huy V Nguyen, Stephen H Tsang

74. Human Retinal Pigment Epithelium Stem Cell (RPESC)
Janmeet S. Saini, Sally Temple, Jeffrey H. Stern

75. Embryonic Stem Cell-Derived Microvesicles: Could They be Used for Retinal Regeneration?
Debora B. Farber, Diana Katsman

76. Intravitreal Implantation of Genetically Modified Autologous Bone Marrow-Derived Stem Cells for Treating Retinal Disorders
Christopher J. Tracy, Douglas N. Sanders, Jeffrey N. Bryan, Cheryl A. Jensen, Leilani J. Castaner, Mark D. Kirk, Martin L. Katz

77. Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina
Claire Hippert, Anna B. Graca, Rachael A. Pearson

78. Interkinetic Nuclear Migration in the Regenerating Retina
Manuela Lahne, David R. Hyde

Part IX. Photoreceptors and Inner Retina

79. Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules
John A. Fuller, Cynthia A. Berlinicke, James Inglese, Donald J. Zack

80. A Novel Approach to Identify Photoreceptor Compartment-Specific Tulp1 Binding Partners
Lindsey A. Ebke, Gayle J.T. Pauer, Belinda Willard, Stephanie A. Hagstrom

81. Thyroid Hormone Signaling and Cone Photoreceptor Viability
Hongwei Ma, Xi-Qin Ding

82. In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination
Naoyuki Tanimoto, Stylianos Michalakis, Bernhard H. F. Weber, Christian A. Wahl-Schott, Hans-Peter Hammes, Mathias W. Seeliger

83. The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium
Daniel G. Taub, Qin Liu

84. Regulation of Retinal Development via the Epigenetic Modification of Histone H3
Sumiko Watanabe, Akira Murakami

85. The Potential Role of Flavins and Retbindin in Retinal Function and Homeostasis
Ryan A. Kelley, Muayyad R. Al-Ubaidi, Muna I. Naash

86. Identification of Tyrosine O Sulfated Proteins in Cow Retina and the 661W Cell Line
Yogita Kanan, Muayyad R. Al-Ubaidi

87. The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors
Christin Hanke-Gogokhia, Houbin Zhang, Jeanne M. Frederick, Wolfgang Baehr

88. Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4
Janise D. Deming, Kathleen Van Craenenbroeck, Yun Sung Eom, Eun-Jin Lee, Cheryl Mae Craft

89. A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina
Kayo Sugitani, Yoshiki Koriyama, Kazuhiro Ogai, Keisuke Wakasugi, Satoru Kato

90. JNK Inhibition Reduced Retinal Ganglion Cell Death after Ischemia/Reperfusion In Vivo and after Hypoxia In Vitro

Nathalie Produit-Zengaffinen, Tatiana Favez, Constantin J. Pournaras, Daniel F. Schorderet

91. Cell Fate of Müller Cells During Photoreceptor Regeneration in an N-Methyl-N-nitrosourea-Induced Retinal Degeneration Model of Zebrafish
Kazuhiro Ogai, Suguru Hisano, Kayo Sugitani, Yoshiki Koriyama, Satoru Kato

92. Polymodal Sensory Integration in Retinal Ganglion Cells
David Križaj

93. Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo

Federica Polato, S. Patricia Becerra

Part X. Retinal Pigment Epithelium (RPE)

94. The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells
Melissa A. Calton, Douglas Vollrath

95. Live Imaging of LysoTracker-Labelled Phagolysosomes Tracks Diurnal Phagocytosis of Photoreceptor Outer Segment Fragments in Rat RPE Tissue Ex Vivo

Yingyu Mao, Silvia C. Finnemann

96. Cre Recombinase: You Can’t Live with It, and You Can’t Live Without It
Yun-Zheng Le, Meili Zhu, Robert E. Anderson

97. Efficiency of Membrane Protein Expression Following Infection with Recombinant Adenovirus of Polarized Non-Transformed Human Retinal Pigment Epithelial Cells
Claudia Müller, Timothy A. Blenkinsop, Jeffrey H. Stern, Silvia C. Finnemann

98. Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: MaxiK, Cav1.3 and Bestrophin-1
Olaf Strauß, Nadine Reichhart, Nestor Mas Gomez, Claudia Müller

99. Lysosomal Trafficking Regulator (LYST)
Xiaojie Ji, Bo Chang, Jürgen K. Naggert, Patsy M. Nishina

100. Live-Cell Imaging of Phagosome Motility in Primary Mouse RPE Cells
Roni Hazim, Mei Jiang, Julian Esteve-Rudd, Tanja Diemer, Vanda S. Lopes, David S. Williams

101. RPE Cell and Sheet Properties in Normal and Diseased Eyes
Alia Rashid, Shagun K. Bhatia, Karina I. Mazzitello, Micah A. Chrenek, Qing Zhang, Jeffrey H. Boatright, Hans E. Grossniklaus, Yi Jiang, John M. Nickerson

102. Valproic Acid Induced Human Retinal Pigment Epithelial Cell Death as Well as its Survival after Hydrogen Peroxide Damage is Mediated by P38 Kinase.
Piyush C Kothary, Benjamin Rossi, Monte A Del Monte

103. Blockade of MerTK Activation by AMPK Inhibits RPE Cell Phagocytosis
Suofu Qin

104. Modulation of V-ATPase by βA3/A1-Crystallin in Retinal Pigment Epithelial Cells
Mallika Valapala, Yuri Sergeev, Eric Wawrousek, Stacey Hose, J Samuel Zigler, Debasish Sinha

105. Proteomic Profiling of Cigarette Smoke Induced Changes in Retinal Pigment Epithelium Cells
Juliane Merl-Pham, Fabian Gruhn, Stefanie M Hauck

106. Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress
Bärbel Rohrer, Mausumi Bandyopadhyay, Craig Beeson

107. Erratum to: The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair
Carolina Abrahan, John D. Ash

Keywords: Medicine & Public Health, Ophthalmology, Neurosciences, Immunology

Publication year
1st ed. 2016
Advances in Experimental Medicine and Biology
Page amount
55 pages
Medicine, Health Care, Mode
Printed ISBN

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