Anderson, Robert E.
Retinal Degenerative Diseases
Part I. Age-Related Macular Degeneration (AMD)
1. Apolipoprotein E Isoforms and AMD
Kimberly A Toops, Li Xuan Tan, Aparna Lakkaraju
2. Role of Chemokines in Shaping Macrophage Activity in AMD
Matt Rutar, Jan M Provis
3. Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD)
Lei Wang, Katayoon B Ebrahimi, Michelle Chyn, Marisol Cano, James T Handa
4. Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?
Elod Kortvely, Marius Ueffing
5. Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration
Manas R Biswal, Cristhian J Ildefonso, Haoyu Mao, Soo Jung Seo, Zhaoyang Wang, Hong Li, Yun Z. Le, Alfred S. Lewin
6. Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration
Andre K. Berner, Mark E. Kleinman
7. A Brief Discussion on Lipid Activated Nuclear Receptors and their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD)
Mayur Choudhary, Goldis Malek
8. Extracellular Matrix Alterations and Deposit Formation in AMD
Rosario Fernandez-Godino, Eric A. Pierce, Donita L. Garland
9. The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration
Cristhian J. Ildefonso, Manas R. Biswal, Chulbul M. Ahmed, Alfred S. Lewin
10. Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration
Mandy L. Lambros, Scott M. Plafker
11. Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease
Wenxin Ma, Wai T. Wong
12. VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration
Alexander G. Marneros
13. Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration
Luciana M. Pujol-Lereis, Nicole Schäfer, Laura B. Kuhn, Bärbel Rohrer, Diana Pauly
14. Gene-Diet Interactions in Age-Related Macular Degeneration
Sheldon Rowan, Allen Taylor
15. Challenges in the Development of Therapy for Dry Age-Related Macular Degeneration
Cynthia X. Wei, Aixu Sun, Ying Yu, Qianyong Liu, Yue-Qing Tan, Isamu Tachibana, Hong Zeng, Ji-Ye Wei
16. Nanoceria: a Potential Therapeutic for Dry AMD
Xue Cai, James F. McGinnis
17. β-amyloidopathy in the Pathogenesis of Age-Related Macular Degeneration in Correlation with Neurodegenerative Diseases
Victor V. Ermilov, Alla A. Nesterova
Part II. Macular Dystrophies/Inherited Macular Degeneration
18. Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans
Martin-Paul Agbaga
19. Mouse Models of Stargardt 3 Dominant Macular Degeneration
Peter Barabas, Aruna Gorusupudi, Paul S Bernstein, David Krizaj
20. Current Progress in Deciphering Importance of VLC-PUFA in the Retina
Lea D. Bennett, Robert E. Anderson
21. Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-Related Macular Degeneration and Potential Therapies
John D. Hulleman
Part III. Inherited Retinal Degenerations
22. Hsp90 as a Potential Therapeutic Target in Retinal Disease
Mònica Aguilà, Michael E. Cheetham
23. Leber Congenital Amaurosis: Genotypes and Retinal Structure Phenotypes
Samuel G. Jacobson, Artur V. Cideciyan, Wei Chieh Huang, Alexander Sumaroka, Hyun Ju Nam, Rebecca Sheplock, Sharon B. Schwartz
24. A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects
Jeremy R. Charette, Ivy S. Samuels, Minzhong Yu, Lisa Stone, Wanda Hicks, Lan Ying Shi, Mark P. Krebs, Jürgen K. Naggert, Patsy M. Nishina, Neal S. Peachey
25. Ablation of
Wei-Chieh Chiang, Victory Joseph, Douglas Yasumura, Michael T. Matthes, Alfred S. Lewin, Marina S. Gorbatyuk, Kelly Ahern, Matthew M. LaVail, Jonathan H. Lin
26. Identification of a Novel Gene on 10q22.1 Causing Autosomal Dominant Retinitis Pigmentosa (adRP)
Stephen P. Daiger, Lori S. Sullivan, Sara J. Bowne, Daniel C. Koboldt, Susan H. Blanton, Dianna K. Wheaton, Cheryl E. Avery, Elizabeth D. Cadena, Robert K. Koenekoop, Robert S. Fulton, Richard K. Wilson, George M. Weinstock, Richard A. Lewis, David G. Birch
27.
Louise M Downs, Gustavo D Aguirre
28. Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization
Joseph Fogerty, Kristin Denton, Brian D. Perkins
29. RDS Functional Domains and Dysfunction in Disease
Michael W. Stuck, Shannon M. Conley, Muna I. Naash
30.
Glenn P. Lobo, Lindsey A. Ebke, Adrian Au, Stephanie A. Hagstrom
31. Understanding Cone Photoreceptor Cell Death in Achromatopsia
Livia S. Carvalho, Luk H. Vandenberghe
32. Geranylgeranylacetone Suppresses
Yoshiki Koriyama, Kazuhiro Ogai, Kayo Sugitani, Suguru Hisano, Satoru Kato
33. My Retina Tracker
Joan K. Fisher, Russell L. Bromley, Brian C. Mansfield
34. A Mini-review: Animal Models of
Shannon E. Boye
35. A Comprehensive Review of Mutations in the
Célia Parinot, Emeline F. Nandrot
Part IV.
36. New Developments in Murine Imaging for Assessing Photoreceptor Degeneration
Marie E. Burns, Emily S. Levine, Eric B. Miller, Azhar Zam, Pengfei Zhang, Robert J. Zawadzki, Edward N. Pugh
37. Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia
Mortada A. Abozaid, Christopher S. Langlo, Adam M. Dubis, Michel Michaelides, Sergey Tarima, Joseph Carroll
38. Quantitative Fundus Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is not Increased in Non-Lesion Areas of Retina
Janet R. Sparrow, Tobias Duncker, Russell Woods, François C. Delori
39. Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with
Michael J. Gale, Shu Feng, Hope E. Titus, Travis B. Smith, Mark E. Pennesi
40. Intra-familial Similarity of Wide-Field Fundus Autofluorescence in Inherited Retinal Dystrophy
Yuka Furutani, Ken Ogino, Akio Oishi, Norimoto Gotoh, Yukiko Makiyama, Maho Oishi, Masafumi Kurimoto, Nagahisa Yoshimura
41. Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy
Akio Oishi, Maho Oishi, Ken Ogino, Satoshi Morooka, Nagahisa Yoshimura
42. The Development of a Cat Model of Retinal Detachment and Re-attachment
Sarah Wassmer, Brian C. Leonard, Stuart G. Coupland, Adam Baker, John Hamilton, Renée Torlone, David N. Zacks, Catherine Tsilfidis
Part V. Mechanisms of Degeneration
43. The Role of X-Chromosome Inactivation in Retinal Development and Disease
Abigail T. Fahim, Stephen P. Daiger
44. A Non-Canonical Role for β-Secretase in the Retina
Qingwen Qian, Sayak K. Mitter, S. Louise Pay, Xiaoping Qi, Catherine Bowes Rickman, Maria B. Grant, Michael E Boulton
45. The Consequences of Hypomorphic RPE65 for Rod and Cone Photoreceptors
Marijana Samardzija, Maya Barben, Philipp Geiger, Christian Grimm
46. The Rate of Vitamin A Dimerization in Lipofuscinogenesis, Fundus Autofluorescence, Retinal Senescence and Degeneration
Ilyas Washington, Leonide Saad
47. Can Vitamin A be Improved to Prevent Blindness due to Age-Related Macular Degeneration, Stargardt Disease and Other Retinal Dystrophies?
Leonide Saad, Ilyas Washington
48. Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina
Seifollah Azadi, Richard S. Brush, Robert E. Anderson, Raju V.S. Rajala
49. Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic Targets
Yvan Arsenijevic
50. Nitric Oxide Synthase Activation as a Trigger of
Suguru Hisano, Yoshiki Koriyama, Kazuhiro Ogai, Kayo Sugitani, Satoru Kato
51. Molecular Principles for Decoding Homeostasis Disruptions in the Retinal Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseases
Nicolas G. Bazan
52. Aging and Vision
Marcel V. Alavi
Part VI. Neuroprotection, Small Molecules and Related Therapeutic Approaches
53. The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair
Carolina Abrahan, John D. Ash
54. Retinal Caveolin-1 Modulates Neuroprotective Signaling
Alaina Reagan, Xiaowu Gu, Stefanie M. Hauck, John D. Ash, Guangwen Cao, Timothy C. Thompson, Michael H. Elliott
55. Photoreceptor Neuroprotection: Regulation of Akt Activation Through Serine/Threonine Phosphatases, PHLPP and PHLPPL
Raju V.S. Rajala, Yogita Kanan, Robert E. Anderson
56. The Role of AMPK Pathway in Neuroprotection
Lei Xu, John D. Ash
57. Tauroursodeoxycholic Acid Protects Retinal Function and Structure in
Eric C. Lawson, Shagun K. Bhatia, Moon K. Han, Moe H. Aung, Vincent Ciavatta, Jeffrey H. Boatright, Machelle T. Pardue
58. Near-Infrared Photobiomodulation in Retinal Injury and Disease
Janis T. Eells, Sandeep Gopalakrishnan, Krisztina Valter
59. Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns
Micah A. Chrenek, Jana T. Sellers, Eric C. Lawson, Priscila P. Cunha, Jessica L. Johnson, Preston E. Girardot, Cristina Kendall, Moon K. Han, Adam Hanif, Vincent T. Ciavatta, Marissa A. Gogniat, John M. Nickerson, Machelle T. Pardue, Jeffrey H. Boatright
60. Small Molecules that Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models
Craig Beeson, Chris Lindsey, Cecile Nasarre, Mausumi Bandyopadhyay, Nathan Perron, Bärbel Rohrer
61. Histone Deacetylase: Therapeutic Targets in Retinal Degeneration
Conor Daly, Jun Yin, Breandán N. Kennedy
62. Therapeutic Approach of Nanotechnology for Oxidative Stress Induced Ocular Neurodegenerative Diseases
Rajendra N. Mitra, Shannon M. Conley, Muna I. Naash
63. Transscleral Controlled Delivery of Geranylgeranylaceton Using a Polymeric Device Protects Rat Retina Against Light Injury
Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe
64. Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa
David A. Parfitt, Michael E. Cheetham
Part VII. Gene Therapy and Antisense
65. Gene Therapy for
Matthew M. LaVail, Douglas Yasumura, Michael T. Matthes, Haidong Yang, William W. Hauswirth, Wen-Tao Deng, Douglas Vollrath
66. Tamoxifen-Containing Eye Drops Successfully Trigger
Anja Schlecht, Sarah V. Leimbeck, Ernst R. Tamm, Barbara M. Braunger
67. Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages
Wenjun Xiong, Constance Cepko
68. Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin Mutation
Shannon M. Conley, Patrick Whalen, Alfred S. Lewin, Muna I. Naash
69. Antisense Oligonucleotide Therapy for Inherited Retinal Dystrophies
Xavier Gerard, Alejandro Garanto, Jean-Michel Rozet, Rob W. J. Collin
70. Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins
Minghao Jin, Songhua Li, Jane Hu, Heather H. Jin, Samuel G. Jacobson, Dean Bok
71. Evaluation of Ocular Gene Therapy in an Italian Patient Affected by Congenital Leber Amaurosis Type 2 Treated in Both Eyes
Francesco Testa, Albert M Maguire, Settimio Rossi, Kathleen Marshall, Alberto Auricchio, Paolo Melillo, Jean Bennett, Francesca Simonelli
Part VIII. Stem Cells and Cell-Based Therapies
72. Regenerative Medicine: Solution in Sight
Qingjie Wang, Jeffrey H. Stern, Sally Temple
73. Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-Derived Retinal Pigment Epithelium Cells
Yao Li, Lawrence Chan, Huy V Nguyen, Stephen H Tsang
74. Human Retinal Pigment Epithelium Stem Cell (RPESC)
Janmeet S. Saini, Sally Temple, Jeffrey H. Stern
75. Embryonic Stem Cell-Derived Microvesicles: Could They be Used for Retinal Regeneration?
Debora B. Farber, Diana Katsman
76. Intravitreal Implantation of Genetically Modified Autologous Bone Marrow-Derived Stem Cells for Treating Retinal Disorders
Christopher J. Tracy, Douglas N. Sanders, Jeffrey N. Bryan, Cheryl A. Jensen, Leilani J. Castaner, Mark D. Kirk, Martin L. Katz
77. Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina
Claire Hippert, Anna B. Graca, Rachael A. Pearson
78. Interkinetic Nuclear Migration in the Regenerating Retina
Manuela Lahne, David R. Hyde
Part IX. Photoreceptors and Inner Retina
79. Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules
John A. Fuller, Cynthia A. Berlinicke, James Inglese, Donald J. Zack
80. A Novel Approach to Identify Photoreceptor Compartment-Specific Tulp1 Binding Partners
Lindsey A. Ebke, Gayle J.T. Pauer, Belinda Willard, Stephanie A. Hagstrom
81. Thyroid Hormone Signaling and Cone Photoreceptor Viability
Hongwei Ma, Xi-Qin Ding
82. In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination
Naoyuki Tanimoto, Stylianos Michalakis, Bernhard H. F. Weber, Christian A. Wahl-Schott, Hans-Peter Hammes, Mathias W. Seeliger
83. The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium
Daniel G. Taub, Qin Liu
84. Regulation of Retinal Development via the Epigenetic Modification of Histone H3
Sumiko Watanabe, Akira Murakami
85. The Potential Role of Flavins and Retbindin in Retinal Function and Homeostasis
Ryan A. Kelley, Muayyad R. Al-Ubaidi, Muna I. Naash
86. Identification of Tyrosine
Yogita Kanan, Muayyad R. Al-Ubaidi
87. The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors
Christin Hanke-Gogokhia, Houbin Zhang, Jeanne M. Frederick, Wolfgang Baehr
88. Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4
Janise D. Deming, Kathleen Van Craenenbroeck, Yun Sung Eom, Eun-Jin Lee, Cheryl Mae Craft
89. A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina
Kayo Sugitani, Yoshiki Koriyama, Kazuhiro Ogai, Keisuke Wakasugi, Satoru Kato
90. JNK Inhibition Reduced Retinal Ganglion Cell Death after Ischemia/Reperfusion
Nathalie Produit-Zengaffinen, Tatiana Favez, Constantin J. Pournaras, Daniel F. Schorderet
91. Cell Fate of Müller Cells During Photoreceptor Regeneration in an
Kazuhiro Ogai, Suguru Hisano, Kayo Sugitani, Yoshiki Koriyama, Satoru Kato
92. Polymodal Sensory Integration in Retinal Ganglion Cells
David Križaj
93. Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors
Federica Polato, S. Patricia Becerra
Part X. Retinal Pigment Epithelium (RPE)
94. The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells
Melissa A. Calton, Douglas Vollrath
95. Live Imaging of LysoTracker-Labelled Phagolysosomes Tracks Diurnal Phagocytosis of Photoreceptor Outer Segment Fragments in Rat RPE Tissue
Yingyu Mao, Silvia C. Finnemann
96. Cre Recombinase: You Can’t Live with It, and You Can’t Live Without It
Yun-Zheng Le, Meili Zhu, Robert E. Anderson
97. Efficiency of Membrane Protein Expression Following Infection with Recombinant Adenovirus of Polarized Non-Transformed Human Retinal Pigment Epithelial Cells
Claudia Müller, Timothy A. Blenkinsop, Jeffrey H. Stern, Silvia C. Finnemann
98. Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: MaxiK, Cav1.3 and Bestrophin-1
Olaf Strauß, Nadine Reichhart, Nestor Mas Gomez, Claudia Müller
99. Lysosomal Trafficking Regulator (LYST)
Xiaojie Ji, Bo Chang, Jürgen K. Naggert, Patsy M. Nishina
100. Live-Cell Imaging of Phagosome Motility in Primary Mouse RPE Cells
Roni Hazim, Mei Jiang, Julian Esteve-Rudd, Tanja Diemer, Vanda S. Lopes, David S. Williams
101. RPE Cell and Sheet Properties in Normal and Diseased Eyes
Alia Rashid, Shagun K. Bhatia, Karina I. Mazzitello, Micah A. Chrenek, Qing Zhang, Jeffrey H. Boatright, Hans E. Grossniklaus, Yi Jiang, John M. Nickerson
102. Valproic Acid Induced Human Retinal Pigment Epithelial Cell Death as Well as its Survival after Hydrogen Peroxide Damage is Mediated by P38 Kinase.
Piyush C Kothary, Benjamin Rossi, Monte A Del Monte
103. Blockade of MerTK Activation by AMPK Inhibits RPE Cell Phagocytosis
Suofu Qin
104. Modulation of V-ATPase by βA3/A1-Crystallin in Retinal Pigment Epithelial Cells
Mallika Valapala, Yuri Sergeev, Eric Wawrousek, Stacey Hose, J Samuel Zigler, Debasish Sinha
105. Proteomic Profiling of Cigarette Smoke Induced Changes in Retinal Pigment Epithelium Cells
Juliane Merl-Pham, Fabian Gruhn, Stefanie M Hauck
106. Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress
Bärbel Rohrer, Mausumi Bandyopadhyay, Craig Beeson
107. Erratum to: The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair
Carolina Abrahan, John D. Ash
Keywords: Medicine & Public Health, Ophthalmology, Neurosciences, Immunology
- Editor
- Anderson, Robert E.
- Ash, John
- Grimm, Christian
- Hollyfield, Joe
- LaVail, Matthew M.
- Rickman, Catherine Bowes
- Publisher
- Springer
- Publication year
- 2016
- Language
- en
- Edition
- 1st ed. 2016
- Series
- Advances in Experimental Medicine and Biology
- Page amount
- 55 pages
- Category
- Medicine, Health Care, Mode
- Format
- Ebook
- eISBN (PDF)
- 9783319171210
- Printed ISBN
- 978-3-319-17120-3