High Density Lipoproteins

Part I. Physiology of HDL

1. Structure of HDL: Particle Subclasses and Molecular Components
Anatol Kontush, Mats Lindahl, Marie Lhomme, Laura Calabresi, M. John Chapman, W. Sean Davidson

2. HDL Biogenesis, Remodeling, and Catabolism
Vassilis I. Zannis, Panagiotis Fotakis, Georgios Koukos, Dimitris Kardassis, Christian Ehnholm, Matti Jauhiainen, Angeliki Chroni

3. Regulation of HDL Genes: Transcriptional, Posttranscriptional, and Posttranslational
Dimitris Kardassis, Anca Gafencu, Vassilis I. Zannis, Alberto Davalos

4. Cholesterol Efflux and Reverse Cholesterol Transport
Elda Favari, Angelika Chroni, Uwe J. F. Tietge, Ilaria Zanotti, Joan Carles Escolà-Gil, Franco Bernini

5. Functionality of HDL: Antioxidation and Detoxifying Effects
Helen Karlsson, Anatol Kontush, Richard W. James

6. Signal Transduction by HDL: Agonists, Receptors, and Signaling Cascades
Jerzy-Roch Nofer

Part II. Pathology of HDL

7. Epidemiology: Disease Associations and Modulators of HDL-Related Biomarkers
Markku J. Savolainen

8. Beyond the Genetics of HDL: Why Is HDL Cholesterol Inversely Related to Cardiovascular Disease?
J. A. Kuivenhoven, A. K. Groen

9. Mouse Models of Disturbed HDL Metabolism
Menno Hoekstra, Miranda Eck

10. Dysfunctional HDL: From Structure-Function-Relationships to Biomarkers
Meliana Riwanto, Lucia Rohrer, Arnold Eckardstein, Ulf Landmesser

Part III. Possible Indications and Target Mechanisms of HDL Therapy

11. HDL and Atherothrombotic Vascular Disease
Wijtske Annema, Arnold Eckardstein, Petri T. Kovanen

12. HDLs, Diabetes, and Metabolic Syndrome
Peter Vollenweider, Arnold Eckardstein, Christian Widmann

13. High-Density Lipoprotein: Structural and Functional Changes Under Uremic Conditions and the Therapeutic Consequences
Mirjam Schuchardt, Markus Tölle, Markus Giet

14. Impact of Systemic Inflammation and Autoimmune Diseases on apoA-I and HDL Plasma Levels and Functions
Fabrizio Montecucco, Elda Favari, Giuseppe Danilo Norata, Nicoletta Ronda, Jerzy-Roch Nofer, Nicolas Vuilleumier

15. HDL in Infectious Diseases and Sepsis
Angela Pirillo, Alberico Luigi Catapano, Giuseppe Danilo Norata

16. High-Density Lipoproteins in Stroke
Olivier Meilhac

17. Therapeutic Potential of HDL in Cardioprotection and Tissue Repair
Sophie Linthout, Miguel Frias, Neha Singh, Bart Geest

Part IV. Treatments for Dyslipidemias and Dysfunction of HDL

18. HDL and Lifestyle Interventions
Joan Carles Escolà-Gil, Josep Julve, Bruce A. Griffin, Dilys Freeman, Francisco Blanco-Vaca

19. Effects of Established Hypolipidemic Drugs on HDL Concentration, Subclass Distribution, and Function
Monica Gomaraschi, Maria Pia Adorni, Maciej Banach, Franco Bernini, Guido Franceschini, Laura Calabresi

20. Emerging Small Molecule Drugs
Sophie Colin, Giulia Chinetti-Gbaguidi, Jan A. Kuivenhoven, Bart Staels

21. ApoA-I Mimetics
R. M. Stoekenbroek, E. S. Stroes, G. K. Hovingh

22. Antisense Oligonucleotides, microRNAs, and Antibodies
Alberto Dávalos, Angeliki Chroni

Keywords: Biomedicine, Pharmacology/Toxicology, Molecular Medicine, Human Physiology, Immunology, Cell Biology