A Systems Biology Approach to Study Metabolic Syndrome

Part I. Introduction

1. The Metabolic Syndrome and its Complex Pathophysiology
Antonio Vidal-Puig

2. Systems Biology in Human Health and Disease
Matej Orešič

Part II. Pathophysiology of Metabolic Syndrome

3. The Liver in Metabolic Syndrome
Simona D’Amore, Giuseppe Palasciano, Antonio Moschetta

4. Role of Adipose Tissue in the Pathogenesis and Treatment of Metabolic Syndrome
David Sanchez-Infantes, Jacqueline M. Stephens

5. The Beta Cell in Metabolic Syndrome
Bader Zarrouki, Ghislaine Fontés, Meriem Semache, Julie Amyot, Vincent Poitout

6. The Skeletal Muscle in Metabolic Syndrome
Antonio Zorzano, David Sebastián, Montserrat Romero

7. The Central Nervous System in Metabolic Syndrome
Luís Martins, Andrew J. Whittle, Rubén Nogueiras, Antonio Vidal-Puig, Carlos Diéguez, Miguel López

8. Lipid Metabolism in Metabolic Syndrome
Jan Borén, Martin Adiels

9. Gut Microbiota in Metabolic Syndrome
Fredrik Bäckhed

Part III. Key Technologies to Study Metabolic Syndrome

10. Proteomics in the Systems-Level Study of the Metabolic Syndrome
Isabel Rubio-Aliaga, Irma Silva-Zolezzi, Michael Affolter, Loïc Dayon, Alexandre Panchaud, Martin Kussmann

11. Metabolomics in the Systems-Level Study of the Metabolic Syndrome
Tuulia Hyötyläinen

12. Fluxomics
Marta Cascante, Adrián Benito, Igor Marín de Mas, Josep J. Centelles, Anibal Miranda, Pedro de Atauri

13.
In vitro Colon Model to Study Metabolic Syndrome
Anna-Marja Aura

Part IV. Modeling Metabolic Syndrome

14. Genome-Scale Modeling of Tissue and Cancer Metabolism
Livnat Jerby, Eytan Ruppin

15. Modeling of Lipid Membranes and Lipoproteins
Artturi Koivuniemi, Ilpo Vattulainen

16. Computational Statistics Approaches to Study Metabolic Syndrome
Ilkka Huopaniemi, Samuel Kaski

17. Towards Modeling of Metabolic Syndrome: Tissue Crosstalk in Lipid Spillover
Sergey Smirnov, Eugeny Metelkin, Nail Gizzatkulov, Oleg Stepanov, Oleg Demin

Keywords: Biomedicine, Biomedicine general, Molecular Medicine, Human Physiology