Key Clinical Trials in Erectile Dysfunction

1. The Earliest Carefully Controlled Clinical Trial Evaluating Oral Pharmacotherapy (Yohimbine) in ED

2. A Description of the Pioneering Work That Led to the First Approved Agents for ED: Giles Brindley, the Needle, and the Penis (Phenoxybenzamine)

3. The Pivotal Study Showing That Intracorporal Injection of Vasoactive Agents (Papaverine or Phenoxybenzamine) Was Effective Pharmacotherapy

4. The First Placebo-Controlled Study on the Benefits of Intracorporal Administration of Vasorelaxant Agents to ED Patients (Papaverine/Phentolamine Combination)

5. Representative Study on the Use of Yohimbine in the Treatment of Organic ED

6. Defining the Therapeutic Ratio for Intracavernosal Administration of Prostaglandin E1 (Alprostadil)

7. An Elegant Long-Term Trial Assessing the Clinical Profile of Intracavernosal Prostaglandin E1 (Alprostadil)

8. Evaluation of Novel Combination (Vasoactive Intestinal Polypeptide and Phentolamine) as Intracavernosal Therapy

9. Now-Classic Study on the Use of Intraurethral Prostaglandin E1 (Alprostadil)

10. Route of Administration Has a Considerable Impact on Clinical Profile: A Comparison of Intraurethral and Intracavernosal Alprostadil

11. First Clinical Data on Sildenafil: The Arrival of Oral Pharmacotherapy

12. Original “Gold Standard” Clinical Trial of Sildenafil in ED

13. Pilot Study Showing Benefit of Clinical Response to Apomorphine Sublingual (SL)

14. A Viable Alternative to PDE Inhibitors: Definition of Therapeutic Ratio of Apomorphine Sublingual (SL) in Patients with ED

15. Summary of Clinical Trials of Phentolamine

16. Impact of Testosterone Replacement in Androgen-Deficient Males

17. Evaluation of Psychotherapy for Patients and Partners

18. Quantification of Benefit of a Vacuum Device on Erectile Function

19. Pioneering Clinical Trial of Surgical Procedures

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Keywords: MEDICAL / Public Health MED078000