Imaging and Focal Therapy of Early Prostate Cancer

Part I. Scientific Foundation for the Focal Therapy Concept

1. Focal Therapy in Other Genitourinary Systems: Renal Cell Carcinoma
Joseph A. Graversen, Jaime Landman

2. Changing Landscape of Prostate Cancer Favoring Low-Risk Prostate Cancer: Implications for Active Surveillance Versus Focal Therapy
Byron H. Lee, Peter R. Carroll, Eric A. Klein

3. Active Surveillance and Focal Therapy: A European Perspective
Hendrik Poppel, Steven Joniau

4. Pathologic Basis for Focal Therapy: Understanding Cancer Grade, Volume, and Spatial Location
Thomas J. Polascik, Arnauld Villers, Thomas M. Wheeler, David G. Bostwick, Rodolfo Montironi, Pierre Nevoux, Vladimir Mouraviev

5. Identifying the Index Lesion
Markos Karavitakis, Mark Emberton, Hashim Uddin Ahmed

6. Molecular Identification of the Indolent Versus Lethal Tumor
G. H. J. M. Leyten, J. A. Schalken

Part II. Advances in Prostate Biopsy Technique

7. Biopsy Strategies to Detect Small Prostate Cancers
Ryan Berglund, J. Stephen Jones

8. 3D Image-Guided Mapping Biopsy for Defining Spatial Distribution of Prostate Cancer
Samuel Clark Berngard, Kyle O. Rove, Jens Rassweiler, Oliver Kalthoff, Marcel Hruz, E. David Crawford

9. Stereotactic, Image-Guided Robotic Biopsy
Osamu Ukimura, André Luis Castro Abreu

10. Multimodality MRI-Guided Targeting
Arnauld Villers, Adil Ouzzane

11. Quality Assurance in Prostate Biopsy Sampling, Processing, and Reporting: A New Pathologic Paradigm for Prostate Cancer Diagnosis
David G. Bostwick

Part III. Functional and Molecular Imaging

12. Contrast-Enhanced Ultrasonography
M. Smeenge, M. Mischi, M. P. Laguna, J. J. M. C. H. Rosette, H. Wijkstra

13. Prostate Elastrography
Stephen Rosenzweig, Liang Zhai, Kathryn R. Nightingale

14. Multiparametric Magnetic Resonance Imaging Approaches in Focal Prostate Cancer Therapy
Sadhna Verma, Michael A. S. Lamba, Daniel B. Vigneron, Adam Jung, John Kurhanewicz

15. Nanomedicines for Diagnosis and Treatment of Prostate Cancer
Nazila Kamaly, Archana Swami, Ryan Wagner, Omid Cameron Farokhzad

16. New Horizons in Molecular Imaging of Prostate Cancer
Baris Turkbey, Peter L. Choyke

Part IV. Focal Therapy Nomenclature and Patient Selection

17. Prostate Focal Therapy: Definitions and Common Terminology
John F. Ward

18. Selection Criteria for Focal Therapy of Prostate Cancer
Vladimir Mouraviev, Thomas J. Polascik

19. Standardisation of Focal Therapy Protocols
Louise Dickinson, Hashim Uddin Ahmed, Mark Emberton

Part V. Novel Thermoablation Technologies for Focal Therapy

20. High Intensity Focused Ultrasound
Satoru Muto, Shigeo Horie

21. Photodynamic Therapy for Early Prostate Cancer
Caroline M. Moore, Mark Emberton

22. MRI-Guided Laser Ablation for Localized Prostate Cancer
Uri Lindner, John Trachtenberg

23. Cell Electroporation Mechanisms and Preclinical Foundation for Focal Therapy
Mark V. Ortiz, Rafael V. Davalos

24. Histotripsy
William W. Roberts

25. Cryoablation
David A. Levy, J. Stephen Jones

26. Optimizing Ablative Therapy: Manipulating the Microenvironment
John M. Baust, Kimberly Santucci, Andrew A. Gage, Anthony Robilotto

Part VI. Post-treatment Follow-Up and Future Directions

27. Setting Rules for Post-ablation and Follow-Up
David S. Finley, Arie S. Belldegrun

28. Roadmap for Focal Therapy
Thomas J. Polascik, Vladimir Mouraviev

29. Optimizing Ablative Therapy Manipulating the Microenvironment
John M. Baust, Kimberly Santucci, Andrew A. Gage, Anthony Robilotto, John G. Baust

Keywords: Medicine & Public Health, Urology/Andrology, Oncology, Imaging / Radiology