Hiyama, Keiko

Telomeres and Telomerase in Cancer

Hiyama, Keiko - Telomeres and Telomerase in Cancer, ebook


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ISBN: 9781603278799
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Table of contents

I. Basic Background

1. Telomeres and Telomerase in Humans
Keiko Hiyama, Eiso Hiyama, Jerry W. Shay

2. Telomere-Binding Proteins in Humans
Nadya Dimitrova

3. Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms
Amy N. Depcrynski, Patrick C. Sachs, Lynne W. Elmore, Shawn E. Holt

4. Telomere Dysfunction and the DNA Damage Response
Malissa C. Diehl, Lynne W. Elmore, Shawn E. Holt

5. Alternative Lengthening of Telomeres in Human Cells
Hilda A. Pickett, Roger R. Reddel

6. Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer
Xin Huang, Zhenyu Ju

II. Telomeres and Telomerase in Human Cancers

7. Role of Telomeres and Telomerase in Cancer
Keiko Hiyama, Eiso Hiyama, Keiji Tanimoto, Masahiko Nishiyama

8. Diagnostic Value I: Solid Tumors
Eiso Hiyama, Keiko Hiyama

9. Diagnostic Value II: Hematopoietic Malignancies
H. Ohyashiki Junko, Ohyashiki Kazuma

10. Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors
Brittney-Shea Herbert, Erin M. Goldblatt

11. Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors
Chandanamali Punchihewa, Danzhou Yang

12. Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors
Hiroyuki Seimiya, Takashi Tsuruo

13. Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer
Toshiyoshi Fujiwara, Yasuo Urata, Noriaki Tanaka

III. Experimental Protocols

14. Protocol I: Telomerase Activity and Telomerase Expression
Eiso Hiyama

15. Protocol II: Importance and Methods of Telomere G-Tail Length Quantification
Akira Shimamoto, Eriko Aoki, Angie M. Sera, Hidetoshi Tahara

16. Protocol III: Detection of Alternative Lengthening of Telomeres
Wei-Qin Jiang, Jeremy D. Henson, A. Neumann Axel, R. Reddel Roger

Keywords: Biomedicine, Cancer Research, Oncology, Pharmacology/Toxicology

Publication year
Cancer Drug Discovery and Development
Page amount
385 pages
Medicine, Health Care, Mode

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