Meir, Erwin G.

CNS Cancer

Meir, Erwin G. - CNS Cancer, ebook


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Table of contents

2. Modeling Gliomas Using PDGF-Expressing Retroviruses
Marcela Assanah, Kim A. Lopez, Jeffrey N. Bruce, Peter Canoll

3. Modeling Brain Tumors Using Avian Retroviral Gene Transfer
Tod D. Holland, Eric C. Holland

4. Using Neurofibromatosis Type 1 Mouse Models to Understand Human Pediatric Low-Grade Gliomas
David H Gutmann

5. Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role of p21-Ras in Glioblastoma Multiforme
Diana Munoz, Sameer Agnihotri, Abhijit Guha

Pten-Deficient Mouse Models for High-Grade Astrocytomas
Chang Hyuk Kwon

7. The Nf1–/+; Trp53–/+cis Mouse Model of Anaplastic Astrocytoma and Secondary Glioblastoma: Dissecting Genetic Susceptibility to Brain Cancer
Karlyne M. Reilly

8. Modeling Astrocytomas in a Family of Inducible Genetically Engineered Mice: Implications for Preclinical Cancer Drug Development
C. Ryan Miller, Natalie O. Karpinich, Qian Zhang, Elizabeth Bullitt, Serguei Kozlov, Terry Dyke

9. Human Brain Tumor Cell and Tumor Tissue Transplantation Models
Tomoko Ozawa, C. David James

10. Transformed Human Brain Cells in Culture as a Model for Brain Tumors
Russell O. Pieper

11. Rat Glioma Models for Preclinical Evaluation of Novel Therapeutic and Diagnostic Modalities
Balveen Kaur, Rolf F. Barth

12. Neuro-oncogenesis Induced by Nitroso Compounds in Rodents and Strain-Specific Genetic Modifiers of Predisposition
Bernd U. Koelsch, Andrea Kindler-Röhrborn

13. The Murine GL261 Glioma Experimental Model to Assess Novel Brain Tumor Treatments
Elizabeth W. Newcomb, David Zagzag

14. Spontaneous Occurrence of Brain Tumors in Animals: Opportunities as Preclinical Model Systems
Simon R. Platt

15. p53 Pathway Alterations in Brain Tumors
Shaoman Yin, Erwin G. Van Meir

16. The PTEN/PI3 Kinase Pathway in Human Glioma
David Stokoe, Frank B. Furnari

17. Value of 1p/19q and Other LOH Markers for Brain Tumor Diagnosis, Prognosis, and Therapy
Jean Louis Boulay, Adrian Merlo

18. Discovery of Genetic Markers for Brain Tumors by Comparative Genomic Hybridization
Anjan Misra, Burt G. Feuerstein

19. Genomic Identification of Significant Targets in Brain Cancer
Rameen Beroukhim, Gaddy Getz, Ingo K Mellinghoff

20. Oncomodulatory Role of the Human Cytomegalovirus in Glioblastoma
Liliana Soroceanu, Charles S. Cobbs

21. Aberrant EGFR Signaling in Glioma
YeoHyeon Hwang, Khatri Latha, Anupama Gururaj, Marta Rojas, Oliver Bogler

22. Mechanisms of Brain Tumor Angiogenesis
Bo Hu, Shi-Yuan Cheng

23. Vaso-occlusive Mechanisms that Intiate Hypoxia and Necrosis in Glioblastoma: The Role of Thrombosis and Tissue Factor
Yuan Rong, Daniel J. Brat

24. Transcription Profiling of Brain Tumors: Tumor Biology and Treatment Stratification
Erik P. Sulman, Marisol Guerrero, Ken Aldape

25. Proteomic Profiling of Human Brain Tumors
Rongcai Jiang, Jian Yi Li, Gregory N. Fuller, Wei Zhang

26. Proteomic Discovery of Biomarkers in the Cerebrospinal Fluid of Brain Tumor Patients
Fatima W. Khwaja, Erwin G. Van Meir

27. Epigenetic Profiling of Gliomas
Raman P. Nagarajan, Joseph F. Costello

28. MicroRNAs in the Central Nervous System and Potential Roles of RNA Interference in Brain Tumors
Benjamin Purow

29. Of Escherichia coli and Man: Understanding Glioma Resistance to Temozolomide Therapy
Clark C. Chen, Kristopher T. Kahle, Kimberly Ng, Masayuki Nitta, Alan D’Andrea

30. Brain Tumor Stem Cell Markers
Jeremy N. Rich

31. Clinical Agents for the Targeting of Brain Tumor Vasculature
Elizabeth R. Gerstner, Tracy T. Batchelor

32. Bone Marrow-Derived Cells in GBM Neovascularization
Gabriele Bergers

33. Vascular Targeting of Brain Tumors – Bridging the Gap with Phage Display
Michael G. Ozawa, Fernanda I. Staquicini, Richard L. Sidman, Renata Pasqualini, Wadih Arap

34. Impact of the Blood–Brain Barrier on Brain Tumor Imaging and Therapy
James Provenzale

35. Targeting CXCR4 in Brain Tumors
Hyunsuk Shim

36. Molecular Targeting of IL-13Rα2 and EphA2 Receptor in GBM
Waldemar Debinski, Jill Wykosky

37. Molecular Targets for Antibody-Mediated Immunotherapy of Malignant Glioma
Joanne E. Ayriss, Chien-Tsun Kuan, Susan T. Boulton, David A. Reardon, Darell D. Bigner

38. Stat3 Oncogenic Signaling in Glioblastoma Multiforme
Saikh Jaharul Haque, Pankaj Sharma

39. Inhibition of Ras Signaling for Brain Tumor Therapy
Sameer Agnihotri, Diana Munoz, Abhijit Guha

40. HGF/c-Met Signaling and Targeted Therapeutics in Brain Tumors
Roger Abounader, John Laterra

41. Combinatorial Therapeutic Strategies for Blocking Kinase Pathways in Brain Tumors
Paul H. Huang, Forest M. White

42. Targeting of TRAIL Apoptotic Pathways for Glioblastoma Therapies
Anita C. Bellail, Patrick Mulligan, Chunhai Hao

43. The NF-κB Signaling Pathway in GBMs: Implications for Apoptotic and Inflammatory Responses and Exploitation for Therapy
Travis Laver, Susan Nozell, Etty N. Benveniste

44. Targeting Endoplasmic Reticulum Stress for Malignant Glioma Therapy
Peter Pyrko, Axel H. Schönthal, Thomas C. Chen

45. Brain Cancer Stem Cells as Targets of Novel Therapies
Jennifer M. Atkinson, Richard J. Gilbertson, Jeremy N. Rich

46. The Use of Retinoids as Differentiation Agents Against Medulloblastoma
Matthew Wortham, Hai Yan

47. Herpes Simplex Virus 1 (HSV-1) for Glioblastoma Multiforme Therapy
Costas G. Hadjipanayis

48. The Development of Targeted Cancer Gene-Therapy Adenoviruses for High-Grade Glioma Treatment
Dawn E. Post, Erwin G. Meir

49. Harnessing T-Cell Immunity to Target Brain Tumors
Paul R. Walker, Robert M. Prins, Pierre-Yves Dietrich, Linda M. Liau

50. Glioma Invasion: Mechanisms and Therapeutic Challenges
Mariano S. Viapiano, Sean E. Lawler

Keywords: Biomedicine, Cancer Research, Pharmacology/Toxicology, Oncology

Publication year
Cancer Drug Discovery and Development
Page amount
37 pages
Medicine, Health Care, Mode

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