Bonetti, Andrea

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Bonetti, Andrea - Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy, ebook


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Table of contents

1. Novel Platinum Analogues, Original Formulations and Other Heavy Metals

1. Platinum Compounds: The Culmination of the Era of Cancer Chemotherapy
Franco M. Muggia

2. Studies on New Platinum Compounds
Fazlul Huq, Jun Qing Yu, Philip Beale

3. Assessment of the In Vivo Antiproliferative Activity of a Novel Platinum Particulate Pharmacophore
Elena Monti, Marzia B. Gariboldi, Raffaella Ravizza, Roberta Molteni, Elisabetta Gabano, Katia Sparnacci, Michele Laus, Domenico Osella

4. Nanocapsules of Platinum-Based Anticancer Drugs
Irene H.L. Hamelers, Anton I.P.M. de Kroon

5. The Design and Development of the Tumor-Targeting Nanopolymer Dach Platinum Conjugate AP5346 (Prolindac)
Stephen B. Howell

6. In vitro Anti-proliferative Effects of ProLindac™, a Novel Dach-Platinum-Linked Polymer Compound, as a Single Agent and in Combination with Other Anti-cancer Drugs
Maria Serova, Aïda Ghoul, Keyvan Rezaï, François Lokiec, Esteban Cvitkovic, David Nowotnik, Sandrine Faivre, Eric Raymond

7. Synthesis of Cisplatin Analogues: Cytotoxic Efficacy and Anti-tumour Activity of Bis-Amidine and Bis-Iminoether Pt(II) Complexes
Roberta Bertani, Silvia Mazzega Sbovata, Valentina Gandin, Rino A. Michelin, Cristina Marzano

8. Ruthenium Drugs for Cancer Chemotherapy: An Ongoing Challenge to Treat Solid Tumours
Gianni Sava, Alberta Bergamo

9. X-ray Crystal Structure of a Monofunctional Platinum–DNA Adduct, cis-{Pt(NH3)2-(Pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex
Ryan C. Todd, Stephen J. Lippard

10. Osmium Arenes: A New Class of Potential Anti-cancer Agents
Sabine H. van Rijt, Anna F. A. Peacock, Peter J. Sadler

2. Cellular Transport and Intracellular Trafficking of Platinum Compounds

11. Resistance to Cisplatin Results from Multiple Mechanisms in Cancer Cells
Michael M. Gottesman, Matthew D. Hall, Xing-Jie Liang, Ding-Wu Shen

12. CTR1 as a Determinant of Platinum Drug Transport
Stephen B. Howell, Roohangiz Safaei

13. Regulation of the Export of Platinum-Containing Drugs by the Copper Efflux Transporters ATP7A and ATP7B
Roohangiz Safaei, Stephen B. Howell

14. Altered Localization of Transport Proteins Associated with Cisplatin Resistance
Ganna V. Kalayda, Ulrich Jaehde

15. How to Overcome Cisplatin Resistance Through Proton Pump Inhibitors
Angelo De Milito, Francesca Luciani, Stefano Fais

16. Cellular Resistance to Oxaliplatin and Drug Accumulation Defects
Laura Gatti, Paola Perego

17. Possible Incorporation of Free N7-Platinated Guanines in DNA by DNA Polymerases, Relevance for the Cisplatin Mechanism of Action
Michele Benedetti, Cosimo Ducani, Danilo Migoni, Daniela Antonucci, Vita M. Vecchio, Alessandro Romano, Tiziano Verri, Francesco P. Fanizzi

3. DNA Damage and Signal Transduction: Recognition/Repair And Cell-Response

18. Structural and Mechanistic Studies of Anticancer Platinum Drugs: Uptake, Activation, and the Cellular Response to DNA Binding
Shanta Dhar, Stephen J. Lippard

19. Platinum Drugs and DNA Repair: Lessons from the NCI Panel and Clinical Correlates
Jacques Robert, Armelle Laurand, Delphine Meynard, Valérie Le Morvan

20. Differences in Conformation and Conformational Dynamics Between Cisplatin and Oxaliplatin DNA Adducts
Stephen G. Chaney, Srinivas Ramachandran, Shantanu Sharma, Nikolay V. Dokholyan, Brenda Temple, Debadeep Bhattacharyya, Yibing Wu, Sharon Campbell

21. Regrowth Resistance: Low-Level Platinum Resistance Mediated by Rapid Recovery from Platinum-Induced Cell-Cycle Arrest
Britta Stordal, Ross Davey

22. Targeting Nucleotide Excision Repair as a Mechanism to Increase Cisplatin Efficacy
John J. Turchi, Sarah C. Shuck, Emily A. Short, Brooke J. Andrews

23. CHK2 and ERCC1 in the DNA Adduct Repair Pathway that Mediates Acquired Cisplatin Resistance
Jing Jie Yu, Xiaobing Liang, Qing-Wu Yan, Eddie Reed, Antonio Tito Fojo, Ying Guo, Qi He, Michael D. Mueller

24. Modulation of Survival Pathways in Ovarian Carcinoma Cells Resistant to Platinum Compounds
Paola Perego, Valentina Benedetti, Cinzia Lanzi, Franco Zunino

25. Paraptotic Cell Death Induced by the Thioxotriazole Copper Complex A0: A New Tool to Kill Apoptosis-Resistant Cancer Cells
Saverio Tardito, Claudio Isella, Enzo Medico, Luciano Marchiò, Maurizio Lanfranchi, Ovidio Bussolati, Renata Franchi-Gazzola

4. Clinical Applications

26. Platinum Compounds and Radiation
Lea Baer, Franco M. Muggia, Silvia C. Formenti

27. Treating Cisplatin-Resistant Cancer: A Systematic Analysis of Oxaliplatin or Paclitaxel Salvage Chemotherapy
Britta Stordal, Nick Pavlakis, Ross Davey

28. Platinum Compounds in Lung Cancer: Current Status
Kevin Tay, Martin Gutierrez, Giuseppe Giaccone

29. Is Lipoplatinum Monotherapy an Active Alternative in Second Line Treatment of Metastatic Non–Small Cell Lung Cancer? A Phase II Trial
Alberto Ravaioli, Manuela Fantini, Fabrizio Drudi, Maximilian Papi, Enzo Pasquini, Maurizio Marangolo, Wainer Zoli, Ilaria Panzini, Britt Rudnas, Stefania VL Nicoletti, Cinzia Possenti, Emiliano Tamburini, Lorenzo Gianni, Manuela Imola

30. Combining Platinums in Gastric Cancer
Florian Lordick, Dirk Jäger

31. Oxaliplatin-Based Chemotherapy for Colon Cancer
Andrea Bonetti, Furini Lara

32. First-Line Systemic Chemotherapy with Folfoxiri Followed by Radical Surgical Resection of Metastases for the Treatment of Unresectable Metastatic Colorectal Cancer Patients
Enrico Vasile, Gianluca Masi, Fotios Loupakis, Samanta Cupini, Giacomo Giulio Baldi, Lorenzo Fornaro, Irene Stasi, Lisa Salvatore, Alfredo Falcone

33. Pre-operative Radio-Chemotherapy of Rectal Cancer: Toxicity and Preliminary Results with the Addition of Weekly Oxaliplatin
Francesco Dionisi, Daniela Musio, Gian Paolo Spinelli, Giuseppe Parisi, Nicola Raffetto, Enzo Banelli, Giovanni Codacci-Pisanelli

34. The Role of Platins in Newly Diagnosed Endometrial Cancer
Paul J. Hoskins

35. Platinum Compounds: Key Ingredients in Ovarian Cancer Treatment and Strategies
Franco M. Muggia

36. Intraperitoneal Chemotherapy: An Important Strategy in Ovarian Cancer Treatment
Franco M. Muggia

37. Novel Strategies for Enhancing the Efficacy of Intraperitoneal Chemotherapy for Patients with Ovarian Cancer
Stephen B. Howell

38. Laparoscopically Assisted Heated Intra-Operative Intraperitoneal Chemotherapy (HIPEC): Technical Aspect and Pharmacokinetics Data
Gwenaël Ferron, Amélie Gesson-Paute, Laurence Gladieff, Fabienne Thomas, Etienne Chatelut, Denis Querleu

39. Organic Cation Transporters 2 as Mediators of Cisplatin Nephrotoxicity
Giuliano Ciarimboli

40. Peripheral Neurotoxicity of Platinum Compounds
Alessandra Gilardini, Guido Cavaletti

41. Platinum Drugs in Children with Cancer
Antonio Ruggiero, Riccardo Riccardi

42. Optimising Carboplatin Dose using Patient Characteristics and Therapeutic Drug Monitoring
Aurélie Pétain, Antonin Schmitt, Fabienne Thomas, Christine Chevreau, Etienne Chatelut

Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000

Publication year
Cancer Drug Discovery and Development
Page amount
409 pages
Medicine, Health Care, Mode

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