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Polunovsky, Vitaly A.

mTOR Pathway and mTOR Inhibitors in Cancer Therapy

Polunovsky, Vitaly A. - mTOR Pathway and mTOR Inhibitors in Cancer Therapy, ebook

186,00€

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ISBN: 9781603272711
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Table of contents

1. mTORC1: A Signaling Integration Node Involved in Cell Growth
Neil Kubica, John Blenis

2. The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions
Zhaohui Feng, Arnold J. Levine

3. mTOR Signaling in Angiogenesis
Henry Mead, Mirjana Zeremski, Markus Guba

4. mTORC1 Signaling and Hypoxia
James Brugarolas

5. mTOR Signaling in Glioblastoma: Lessons Learned from Bench to Bedside
David Akhavan, Paul S. Mischel

6. mTOR and Cancer Therapy: General Principles
Peter J. Houghton

7. mTOR and Cancer Therapy: Clinical Development and Novel Prospects
Sandrine Faivre, Thomas Decaens, Eric Raymond

8. Drug Combinations as a Therapeutic Approach for mTORC1 Inhibitors in Human Cancer
Madlaina Breuleux, Heidi A. Lane

9. Downstream Targets of mTORC1
Bruno D. Fonseca, Christopher G. Proud

10. Downstream of mTOR: Translational Control of Cancer
Ryan J. O. Dowling, Nahum Sonenberg

11. Genome-Wide Analysis of Translational Control
Ola Larsson, Peter B. Bitterman

12. Translational Control of Cancer: Implications for Targeted Therapy
Peter B. Bitterman, Vitaly A. Polunovsky

13. Downstream from mTOR: Therapeutic Approaches to Targeting the eIF4F Translation Initiation Complex
Jerry Pelletier, Jeremy R. Graff

Keywords: Biomedicine, Cancer Research, Cell Biology, Pharmacology/Toxicology

Author(s)
 
Publisher
Springer
Publication year
2010
Language
en
Edition
1
Series
Cancer Drug Discovery and Development
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (PDF)
9781603272711

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