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Jakowlew, Sonia B.

Transforming Growth Factor-β in Cancer Therapy, Volume II

Jakowlew, Sonia B. - Transforming Growth Factor-β in Cancer Therapy, Volume II, ebook

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ISBN: 9781597452939
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Table of contents

I. Transforming Growth Factor-β In Developing and Advanced Cancers

1. Transforming Growth Factor-β Signaling in Pancreas Development and Pancreatic Disease
Sushil G. Rane, Huei-Min Lin, Ji-Hyeon Lee

2. Role of Transforming Growth Factor-β in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma
Stephen M. Weber, Shi-Long Lu, Sophia Bernstein, Xiao-Jing Wang

3. TGF-β, Smads and Cervical Cancer
Devarajan Karunagaran, Goodwin Jinesh

4. TGF-β Signaling and Biglycan in Pancreatic Cancer
Hendrik Ungefroren

5. TGF-β Signaling in Endometrial Cancer
Dagmara Piestrzeniewicz-Ulanska, David H. McGuinness, Grant R. Yeaman

6. TGF-β Ligands, TGF-β Receptors, and Lung Cancer
Guiying Y. Wang, Xiaochua H. Hu, Rongmei M. Zhang, Lindsey J. Leach, Zewei W. Luo

7. Role of TGF-β in Osteolytic Bone Metastases
Laurent Bartholin, Theresa Guise

8. Hormonal Regulation of Transforming Growth Factor-β in Breast Cancer
Miriam Buck, Cornelius Knabbe

9. TGF-β and Progression of Esophageal Cancer
Minoru Fukuchi, Hiroyuki Kato, Hiroyuki Kuwano

10. TGF-β and HER2/ErbB2 and Breast Cancer Progression
Nataša Todorović-Raković

11. TGF-β Dependent T-Cell Regulation in Colitis and Colon Cancer
Christoph Becker, Markus F. Neurath

12. Role of Transforming Growth Factor-β in the Kidney — Physiology and Pathology
Elena Gagliardini, Ariela Benigni

13. Perturbations of TGF-β Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis
Lawrence A. Wolfraim, John J. Letterio

14. Transforming Growth Factor-β in Brain Functions and Dysfunctions
Denis Vivien, Karim Benchenane, Carine Ali

15. Inhibition of TGF-β Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment
Hiroshi Yasui, Teru Hideshima, Kenneth C. Anderson

16. Key Roles of TGF-β and Smad3 in Prostate Cancer
Kyung Song, David Danielpour

17. Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-β Type I Receptor
Francis Ruscetti, Salem Akel, Maria Birchenall-Roberts, Zhouhong Cao, Anita B. Roberts

II. Transforming Growth Factor-β in Cancer Treatment and Therapy

18. High-Throughput Screening of Protein Interaction Networks in the TGFβ Interactome: Understanding the Signaling Mechanisms Driving Tumor Progression
Miriam Barrios-Rodiles, Alicia Viloria-Petit, Kevin R. Brown, Igor Jurisica, Jeffrey L. Wrana

19. Tumor Suppressor and Pro-progression Roles for TGF-β in Breast Cancer
Ethan A. Kohn, Binwu Tang

20. Tumor Suppressors p53 and TGFβ Converge to Regulate the Alpha-Fetoprotein Oncodevelopmental Tumor Marker
Deepti S. Wilkinson, Michelle Craig Barton

21. TGFβ: Roles in DNA Damage Responses
Kumari L. Andarawewa, Julia Kirshner, Joni D. Mott, Mary Helen Barcellos-Hoff

22. The Rationale for and Effects of Targeting TGF-β for Glioma Therapy
Anita B. Hjelmeland, Jeremy N. Rich

23. Tumor Suppressor Functions of TGFβ1 in T Cells
Ramireddy Bommireddy, Thomas Doetschman

24. Therapeutic Effects of Adenovirus-Mediated Gene Transfer of TGF-β Signal Antagonists on Undesirable Epithelial-Mesenchymal Transition and Neovascularization
Shizuya Saika

25. Role of TGF-β in Tumor Protection and Antitumor Immunity
Catherine M. Bollard, Cliona M. Rooney

26. Regulation of Angiogenesis and Tumor Growth by Thrombospondin-1
Karen O. Yee, Jack Lawler

27. Cancer-Associated Fibroblasts and the Role of TGF-β
Patrick Micke, Aristidis Moustakas, Mitsuhiro Ohshima, Kai Kappert

28. Adoptive Transfer of Tumor Reactive TGF-β Insensitive CD8+ T-cells for Cancer Therapy
Chung Lee, Ali Shah, Victoria C. Liu, Irwin I. Park, Larry Y. Wong, Xuemei Huang, Lijun Huang, Vivian W. Zhou, Terry Medler, Shilajit D. Kundu, Qiang Zhang, Norm D. Smith

29. DNA Methylation and Histone Deacetylation Inhibitors as Potential Therapeutic Agents for the Reconstitution of TGF-β Signaling in Breast Cancer
Sudhakar Ammanamanchi, Michael G. Brattain

30. Reactive Stroma and Evolution of Tumors: Integration of Transforming Growth Factor-β, Connective Tissue Growth Factor, and Fibroblast Growth Factor-2 Activities
David R. Rowley

31. TGF-β Signaling and Vascular Morphogenesis
Evangelia Pardali, Zhen Liu, Marion Scharpfenecker, Peter Dijke

32. Aberrant Transforming Growth Factor-β Signaling in Human Pancreatic Cancer: Translational Implications
Murray Korc

33. TGF-β and Stromal Influences Over Local Tumor Invasion
Sylviane Dennler, Alain Mauviel, Franck Verrecchia

34. TGF-β at the Crossroads Between Inflammation, Suppression and Cancer
Nancy L. McCartney-Francis, Sharon M. Wahl

III. Development of Inhibitors of Transforming Growth Factor-β Signaling for Therapy

35. Transforming Growth Factor-β (TGF-β) Signaling Inhibitors in Cancer Therapy
Pran K. Datta, Jason R. Mann

36. Targeting TGF-β as a Strategy to Ameliorate Intestinal Side Effects of Radiation Therapy
Marjan Boerma, Junru Wang, Michael J. Corbley, Martin Hauer-Jensen

37. Targeting Transforming Growth Factor-β in Metastasis: In Vitro and In Vivo Mechanisms
Michael Reiss

38. Targeted Downregulation of TGF-β2 with AP 12009 in Tumor Therapy
Karl-Hermann Schlingensiepen, Piotr Jachimczak, Birgit Fischer-Blass, Dagmar Fischer, Heike Specht, Susanne Schmaus, Reimar Schlingensiepen

39. Modulating TGF-β Receptor Signaling: A Novel Approach of Cancer Therapy
Ulrike Naumann, Michael Weller

40. Engineering TGF-β Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-β Action
Gregory Crescenzo, Heman Chao, John Zwaagstra, Yves Durocher, Maureen D. O’Connor-McCourt

41. The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology
Leona E. Ling, Juswinder Singh, Claudio E. Chuaqui, P. Ann Boriack-Sjodin, Michael J. Corbley, Doreen J. Lepage, Erika L. Silverio, Lihong Sun, James L. Papadatos, Feng Shan, Timothy Pontz, H. -Kam Cheung, Xiamei Zhang, Robert M. Arduini, Jonathan N. Mead, Miki N. Newman, Scott Bowes, Serene Josiah, Wen-Cherng Lee

42. Soluble Type II Transforming Growth Factor-β Receptor Inhibits Tumorigenesis by Augmenting Host Antitumor Immunity
Eiji Suzuki, Steven M. Albelda

43. Reversal of EMT by Small-Molecule Inhibitors of TGF-β Type I and II Receptors: Implications for Carcinoma Treatment
Markus D. Lacher, W. Michael Korn, Rosemary J. Akhurst

44. Soluble TGF-β Type III Receptor Suppresses Malignant Progression of Human Cancer Cells
Abhik Bandyopadhyay, LuZhe Sun

45. Targeting Smad-Dependent TGF-β Signaling with Peptide Aptamers
F. Michael Hoffmann, Qiqi Cui, S. Kyun Lim, Bryan M. Zhao

46. Rationale for Anti-TGF-β Antibody Therapy in Oncology
Frank J. Hsu, Beverly A. Teicher, John M. McPherson

Keywords: Medicine & Public Health, Oncology, Cancer Research, Cell Biology, Pathology

Author(s)
Publisher
Springer
Publication year
2008
Language
en
Edition
1
Series
Cancer Drug Discovery and Development
Page amount
812 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (PDF)
9781597452939

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