Antimicrobial Drug Resistance

A. General Overview

1. History of Drug-Resistant Microbes
George A. Jacoby

2. Evolutionary Biology of Drug Resistance
Fernando Baquero, Rafael Cantón

3. Pharmacology of Drug Resistance
G. L. Drusano

4. Antimicrobial Resistance Versus the Discovery and Development of New Antimicrobials
David M. Shlaes, Steven J. Projan

B. General Mechanisms of Drug Resistance

5. Genetic Mechanisms of Transfer of Drug Resistance
Paul H. Roy

6. Mutations as a Basis of Antimicrobial Resistance
Maja Babic, Robert A. Bonomo

7. Target-Mediated Antibacterial Resistance
Louis B. Rice

8. Biochemical Logic of Antibiotic Inactivation and Modification
Vanessa D'Costa, Gerard D. Wright

9. Antibiotic Resistance Due to Reduced Uptake
Joseph B. McPhee, Sandeep Tamber, Michelle D. Brazas, Shawn Lewenza, Robert E. W. Hancock

10. Transport Mechanisms of Resistance to Drugs and Toxic Metals
Adrian R. Walmsley, Barry P. Rosen

11. The Functional Resistance of Bacterial Biofilms
Christoph A. Fux, Paul Stoodley, Mark Shirtliff, J. William Costerton

C. Bacterial Drug Resistance – Mechanisms

12. The Importance of β-Lactamases to the Development of New β-Lactams
Karen Bush

13. Penicillin-Binding Proteins and β-Lactam Resistance
André Zapun, Pauline Macheboeuf, Thierry Vernet

14. Aminoglycosides: Mechanisms of Action and Resistance
Maria L. Magalhães, John S. Blanchard

15. Tetracycline and Chloramphenicol Resistance Mechanisms
Marilyn C. Roberts, Stefan Schwarz

16. Fluoroquinolone Resistance in Bacteria
Varsha V. Moudgal, Glenn W. Kaatz

17. Plasmid-Mediated Quinolone Resistance
George A. Jacoby

18. Macrolides and Lincosamides
Annie Canu, Roland Leclercq

19. Mechanism of Resistance in Metronidazole
Abhay Dhand, David R. Snydman

20. Glycopeptide Resistance in Enterococci
Bruno Périchon, Patrice Courvalin

21. Streptogramin
Kimberly D. Leuthner, Michael J. Rybak

22. Resistance to Linezolid
Dean Shinabarger, George M. Eliopoulos

23. Sulfonamides and Trimethoprim
Ola Sköld

24. Mechanisms of Action and Resistance of Antimycobacterial Agents
Petros C. Karakousis

D. Fungal Drug Resistance – Mechanisms

25. Amphotericin B: Polyene Resistance Mechanisms
Elizabeth M. O'Shaughnessy, Caron A. Lyman, Thomas J. Walsh

26. Fungal Drug Resistance: Azoles
Jose L. Lopez-Ribot, Thomas F. Patterson

27. Flucytosine: Site of Action, Mechanism of Resistance and Use in Combination Therapy
Jyotsna Chandra, Sotohy Mohammad, Mahmoud A. Ghannoum

28. Echinocandins: Exploring Susceptibility and Resistance
Cameron M. Douglas

29. Antifungal Targets, Mechanisms of Action, and Resistance in Candida albicans

Robert A. Akins, Jack D. Sobel

E. Viral Drug Resistance – Mechanisms

30. Mechanisms of Resistance of Antiviral Drugs Active Against the Human Herpes Viruses
Clyde S. Crumpacker

31. Influenza M2 Ion-Channel and Neuraminidase Inhibitors
Margaret Tisdale

32. Molecular Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors
Marleen C. D. G. Huigen, Charles A. B. Boucher

33. Resistance to HIV Non-Nucleoside Reverse Transcriptase Inhibitors
Robert Elston, Pierre R. Bonneau

34. Resistance to HIV-1 Protease Inhibitors
Louise Doyon, Robert Elston, Pierre R. Bonneau

35. Resistance to Enfuvirtide and Other HIV Entry Inhibitors
Thomas Melby, Gabrielle Heilek, Nick Cammack, Michael L. Greenberg

36. Resistance to Inhibitors of Human Immunodeficiency Virus Type I Integration
Daria J. Hazuda

37. The Hepatitis B Virus and Antiviral Drug Resistance: Causes, Patterns, and Mechanisms
Stephen Locarnini

38. Mechanisms of Hepatitis C Virus Drug Resistance
Samir Ali, George Kukolj

F. Parasitic Drug Resistance – Mechanisms

39. Drug Resistance Mechanisms in Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Opportunistic Anaerobic Protozoa
Esther Orozco, Laurence A. Marchat, Consuelo Gómez, César López-Camarillo, D. Guillermo Pérez

40. Mechanisms of Antimalarial Drug Resistance
Giancarlo A. Biagini, Patrick G. Bray, Stephen A. Ward

41. Drug Resistance in Leishmania

Hiranmoy Bhattacharjee, Rita Mukhopadhyay

42. Drug Resistance in African Trypanosomiasis
Thomas Seebeck, Pascal Mäser

43. Drug Resistance and Emerging Targets in the Opportunistic Pathogens Toxoplasma gondii and Cryptosporidium parvum

Boris Striepen

44. Drug Resistance in Nematodes
Roger Prichard

45. Chemotherapy and Drug Resistance in Schistosomiasis,Fascioliasis and Tapeworm Infections
Michael J. Doenhoff, Gerald C. Coles, Livia Pica-Mattoccia, Katherine Wheatcroft-Francklow

46. Drug Resistance in Ectoparasites of Medical and Veterinary Importance
Kathryn Stafford, Gerald Coles

Keywords: Medicine & Public Health, Infectious Diseases