Molecular and Cellular Mechanobiology

Part I. Mechanosensors

1. The Primary Cilium as a Strain Amplifying Microdomain for Mechanotransduction at the Cell Membrane
Emily R. Moore, Christopher R. Jacobs

2. Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress
Li-Jing Chen, Wei-Li Wang, Jeng-Jiann Chiu

3. Cadherins in Mechanotransduction
D. E. Leckband

Part II. Transducers

4. Emerging Roles of YAP/TAZ in Mechanobiology
Yubing Sun, Yue Shao, Xufeng Xue, Jianping Fu

5. Role of Rho GTPases in Mechanobiology
Christopher A. McCulloch

6. Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions
Vinay Swaminathan, Clare M. Waterman

Part III. Epigenetic and Genetic Regulations in the Nucleus

7. Perspectives of FRET Imaging to Study Epigenetics and Mechanobiology in the Nucleus
Qin Peng, Binbin Cheng, Shaoying Lu, Shu Chien, Yingxiao Wang

8. Mechanotransduction to Epigenetic Remodeling
Douglas Kelkhoff, Timothy Downing, Song Li

9. The Nuclear Lamina: From Mechanosensing in Differentiation to Cancer Cell Migration
Jerome Irianto, Irena L. Ivanovska, Joe Swift, Dennis E. Discher

10. Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression
Yejun Wang, Ekta Makhija, Karthik Damodaran, G. V. Shivashankar

Part IV. Applications

11. Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine
Andrew J. Putnam

12. Heart Valve Mechanobiology in Development and Disease
Aileen Zhong, Craig A. Simmons

13. Molecular and Cellular Mechanobiology of Cancer
Laurent Fattet, Jing Yang

Keywords: Biomedicine, Human Physiology, Cell Physiology, Atomic/Molecular Structure and Spectra, Protein Science, Molecular Medicine