Circulating Tumor Cells

Part I. Technologies for CTC Identification

1. Significance of Studying Circulating Tumor Cells
Ram H. Datar, Zheng Ao, Richard J. Cote

2. Affinity-Based Enrichment of Circulating Tumor Cells
Zheng Ao, Richard J. Cote, Ram H. Datar

3. Size-Based and Non-Affinity Based Microfluidic Devices for Circulating Tumor Cell Enrichment and Characterization
Zheng Ao, Kamran Moradi, Richard J. Cote, Ram H. Datar

4. Molecular Assays for the Detection and Molecular Characterization of CTCs
Evi S. Lianidou, Athina Markou, Areti Strati

5. Cancer Stem Cells and Circulating Tumor Cells: Molecular Markers, Isolation Techniques, and Clinical Implications
Ebrahim Azizi, Sunitha Nagrath, Molly Kozminsky, Max S. Wicha

Part II. Fundamental Studies of CTC

6. Circulating Tumor Cells and Tumor Dormancy
Alison L. Allan, Ann F. Chambers

7. Prevention of Conversion of Tumor Dormancy into Proliferative Metastases
Dalit Barkan, Ann F. Chambers

8. Genesis of Circulating Tumor Cells Through Epithelial–Mesenchymal Transition as a Mechanism for Distant Dissemination
Bee Luan Khoo, Prashant Kumar, Chwee Teck Lim, Jean Paul Thiery

Part III. CTC Analysis

9. CTC Analysis: FISH, ISH, Array-CGH, and Other Molecular Assays
Verena Tiran, Marija Balic, Nadia Dandachi

10. Genome-Wide Gene Copy Number Analysis of Circulating Tumor Cells
Mark Jesus M. Magbanua, John W. Park

11. Perspectives on the Functional Characterization and In Vitro Maintenance of Circulating Tumor Cells
Anthony Williams, Ramdane Harouaka, Siyang Zheng, Chris Albanese, Richard Schlegel, Yu-Chong Tai, Ram H. Datar, Richard J. Cote

12. Prognostic Implications of CTC in Breast Cancer
Jeffrey B. Smerage

Part IV. Potential Clinical Applications of CTC

13. CTC in Advanced Breast Cancer Prognosis, Monitoring, and Clinical Utility
Massimo Cristofanilli

14. Evolution of Metastatic Disease: The Need for Monitoring and Emerging Therapeutic Opportunities
Bernhard Polzer, Christoph A. Klein

15. CTCs for Biomarker and Companion Diagnostic Development
Shih-Min A. Huang, Mark R. Lackner

16. Perspectives on Clinical Applications of CTCs
Rajan P. Kulkarni, Stefanie S. Jeffrey

Keywords: Biomedicine, Cancer Research