Translational Neuroscience

1. Introduction
Mark H. Tuszynski

Part I. Molecular Approaches

2. Gene Therapy of CNS Disorders Using Recombinant AAV Vectors
Giridhar Murlidharan, R. Jude Samulski, Aravind Asokan

3. NGF and BDNF Gene Therapy for Alzheimer’s Disease
Mark H. Tuszynski, Alan H. Nagahara

4. GDNF and AADC Gene Therapy for Parkinson’s Disease
Krystof Bankiewicz, Waldy San Sebastian, Lluis Samaranch, John Forsayeth

5. GAD Gene Therapy for Parkinson’s Disease
Michael G. Kaplitt, Matthew J. During

6. Antisense Oligonucleotides for Amyotrophic Lateral Sclerosis
Wade K. Self, Timothy M. Miller

7. Gene Therapy for Inborn Errors of Metabolism: Batten Disease
Dolan Sondhi, Ronald G. Crystal, Stephen M. Kaminsky

8. Gene Therapy for Spinal Cord Injury
Ioana Goganau, Armin Blesch

9. Gene Therapy for Epilepsy
Thomas J. McCown

10. Translating Gene Therapy for Pain from Animal Studies to the Clinic
Darren Wolfe, David Krisky, James Goss, James Wechuck, Marina Mata, David J. Fink

Part II. Cellular Approaches

11. Stem Cells for Parkinson’s Disease
Andrés M. Bratt-Leal, Jeanne F. Loring

12. Could Stem Cells Be Used to Treat or Model Alzheimer’s Disease?
Edsel M. Abud, Mathew Blurton-Jones

13. Stem Cells for Amyotrophic Lateral Sclerosis
Anthony Donsante, Lindsey Nicole Urquia, Nicholas M. Boulis

14. Stem Cells for Multiple Sclerosis
Pamela Sarkar, Neil Scolding

15. Cell Therapy for Pediatric Disorders of Glia
M. Joana Osorio, Steven A. Goldman

16. Neural Stem Cells for Spinal Cord Injury
Paul Lu, Ruhel Ahmad, Mark H. Tuszynski

17. Marrow-Derived Mesenchymal Stromal Cells in the Treatment of Stroke
Steven C. Cramer

18. Glioma Stem Cells
Regina Teresa Martuscello, Brent A. Reynolds, Santosh Kesari

Part III. Novel Pharmacological Approaches

19. Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer’s Disease
Kevin D. Rynearson, Rudolph E. Tanzi, Steven L. Wagner

20. Blocking the Nogo-A Signaling Pathway to Promote Regeneration and Plasticity After Spinal Cord Injury and Stroke
Anna Magdalena Guzik-Kornacka, Flóra Vajda, Martin E. Schwab

21. Intrinsic Neuronal Mechanisms in Axon Regeneration After Spinal Cord Injury
Fengfeng Bei, Zhigang He

22. Voltage-Gated Ion Channels as Molecular Targets for Pain
Gerald W. Zamponi, Chongyang Han, Stephen G. Waxman

Part IV. Activity-Dependent Plasticity and Neurorehabilitation

23. Rehabilitation-Dependent Neural Plasticity After Spinal Cord Injury
Lea Awai, Volker Dietz, Armin Curt

24. Neural Prostheses for Neurotrauma
Arthur Prochazka

25. Why Is Functional Electrical Stimulation Therapy Capable of Restoring Motor Function Following Severe Injury to the Central Nervous System?
Mary K. Nagai, Cesar Marquez-Chin, Milos R. Popovic

26. Deep Brain Stimulation for Neuropsychiatric Disorders
Ausaf A. Bari, Nicolas Kon Kam King, Nir Lipsman, Andres M. Lozano

27. Novel Interventions for Stroke: Nervous System Cooling
Patrick D. Lyden, Jessica Lamb, Padmesh S. Rajput

28. Rehabilitation Strategies for Restorative Approaches After Stroke and Neurotrauma
Bruce H. Dobkin

29. Bridging the Chasm Between Scientific Discovery and a Pivotal Clinical Trial for a CNS Disorder: A Checklist
John D. Steeves

30. Conclusion
Mark H. Tuszynski

Keywords: Biomedicine, Neurosciences, Neurology, Neurobiology