Drug Delivery to the Brain

Part I. Physiology and Basic Principles for Drug Handling by the Brain

1. Anatomy and Physiology of the Blood–Brain Barriers
N. Joan Abbott

2. Recent Progress in Blood–Brain Barrier and Blood–CSF Barrier Transport Research: Pharmaceutical Relevance for Drug Delivery to the Brain
Masanori Tachikawa, Yasuo Uchida, Sumio Ohtsuki, Tetsuya Terasaki

3. Blood–Brain Barrier (BBB) Pharmacoproteomics: A New Research Field Opened Up by Quantitative Targeted Absolute Proteomics (QTAP)
Yasuo Uchida, Masanori Tachikawa, Sumio Ohtsuki, Tetsuya Terasaki

4. Drug Metabolism at the Blood–Brain and Blood–CSF Barriers
Xavier Declèves, Nathalie Strazielle, Jean-Michel Scherrmann, Jean-François Ghersi-Egea

Part II. Pharmacokinetic Concepts and Methods for Studying Drug Delivery

5. Pharmacokinetic Concepts in Brain Drug Delivery
Margareta Hammarlund-Udenaes

6. In Vitro Models of CNS Barriers
N. Joan Abbott, Diana E. M. Dolman, Siti R. Yusof, Andreas Reichel

7. In Situ and In Vivo Animal Models
Quentin R. Smith, Ramakrishna Samala

8. Principles of PET and Its Role in Understanding Drug Delivery to the Brain
Stina Syvänen, Roger N. Gunn

9. PKPD Aspects of Brain Drug Delivery in a Translational Perspective
Elizabeth C. M. Lange

Part III. Industrial Approaches for Investigation of Potential Central Nervous System Drugs

10. Drug Discovery Methods for Studying Brain Drug Delivery and Distribution
Irena Loryan, Margareta Hammarlund-Udenaes

11. Prediction of Drug Exposure in the Brain from the Chemical Structure
Markus Fridén

12. Integrated Approach to Optimizing CNS Penetration in Drug Discovery: From the Old to the New Paradigm and Assessment of Drug–Transporter Interactions
Andreas Reichel

13. Pharmacoeconomic Considerations in CNS Drug Development
David Gray

Part IV. Strategies for Improved Central Nervous System Drug Delivery

14. Intranasal Drug Delivery to the Brain
Jeffrey J. Lochhead, Robert G. Thorne

15. Blood-to-Brain Drug Delivery Using Nanocarriers
Pieter J. Gaillard, Corine C. Visser, Marco Boer, Chantal C. M. Appeldoorn, Jaap Rip

16. Development of New Protein Vectors for the Physiologic Delivery of Large Therapeutic Compounds to the CNS
Reinhard Gabathuler

17. CNS Gene Therapy Utilizing Intravenously Administered Viral Vectors
Adam K. Bevan, Brian K. Kaspar

18. Neurosurgical Approaches: Drug Infusion Directly into the Parenchyma or the Cerebrospinal Fluid
Krystof Bankiewicz

19. Osmotic Opening of the BBB for Drug Treatment of Brain Tumors (Focus on Methodological Issues)
David Fortin

20. Emerging Engineering Technologies for Opening the BBB
Elisa E. Konofagou

Part V. Brain Drug Delivery in Disease Conditions

21. Disease Influence on BBB Transport in Inflammatory Disorders
Geert J. Schenk, Gijs Kooij, Arie Reijerkerk, Helga Vries

22. Disease Influence on BBB Transport in Neurodegenerative Disorders
Elizabeth C. M. Lange

23. Drug Delivery in the Context of Stroke and Brain Trauma
Richard F. Keep, Jianming Xiang, Ningna Zhou, Anuska V. Andjelkovic

24. Which Drug or Drug Delivery Method Can Change Clinical Practice for Brain Tumor Therapy?
Tali Siegal

Keywords: Biomedicine, Pharmaceutical Sciences/Technology, Biomedicine general