Role of Proteases in Cellular Dysfunction

Part I. Proteases and Neural Disorders

1. Role of Calpain in Immunobiology of Neurodegenerative Diseases
Nicole Trager, Azizul Haque, Swapan K. Ray, Arabinda Das, Naren L. Banik

2. Calpain Interactions with the Protein Phosphatase Calcineurin in Neurodegeneration
Christopher M. Norris

3. Involvement of Caspases in the Pathophysiology of Neurodegeneration and Stroke
Alakananda Goswami, Prosenjit Sen, Kuladip Jana, Sanghamitra Raha

4. Matrix Metalloproteinases in Ischemia–Reperfusion Injury in Brain: Antioxidants as Rescuer
Sibani Sarkar, Somnath Chatterjee, Snehasikta Swarnakar

5. The Role of Matrix Metalloproteinases in Neurovascular Injury
Ji Hae Seo, Shuzhen Guo, Josephine Lok, Deepti Navaratna, Changhong Xing, Eng H. Lo

6. The Role of Proteases in Embryonic Neural Crest Cells
Avi Bar, Irit Shoval, Efrat Monsonego-Ornan, Dalit Sela-Donenfeld

Part II. Proteases and Cancer

7. Proteases and Cancer Development
Shudong Zhu, Zhoufang Li

8. Matrix Metalloproteinase and Its Inhibitors in Cancer Progression
Ajay K. Chaudhary, Anita H. Nadkarni, Shruti Pandya, Kanjaksha Ghosh

9. Ubiquitin–Proteasome System in the Hallmarks of Cancer
Pushpak Bhattacharjee, Minakshi Mazumdar, Deblina Guha, Gaurisankar Sa

10. Matrix Metalloproteinases in Cancer Metastasis: An Unsolved Mystery
Shravanti Mukherjee, Argha Manna, Minakshi Mazumdar, Tanya Das

11. A Disintegrin and Metalloproteinase-12 as a New Target for Cancer Treatment
Alpana Ray, Bimal K. Ray

12. Proteases and Their Role in Drug Development with an Emphasis in Cancer
Sindhuri Upadrasta, Neeru Saini

Part III. Proteases and Cardiovascular Defects

13. Role of Matrix Metalloproteinases in Atherosclerosis
Karina Gregoli, Jason L. Johnson

14. The Importance of the Urokinase-Type Plasminogen Activator and Its Receptor for the Development and Progression of Atherosclerosis
Nicole Paland, Bianca Fuhrman

15. Matrix Metalloproteinases and Hypertension
Alejandro F. Prado, Michele M. Castro, Raquel F. Gerlach

16. Regulation of Proteolysis in Vascular Remodeling
Erin R. Mandel, Cassandra Uchida, Tara L. Haas

17. Emerging Role of Genetic Variants of Matrix Metalloproteinases Genes in Left Ventricular Dysfunction
Balraj Mittal, Avshesh Mishra, Anshika Srivastava, Naveen Garg

18. Implications of Intracellular Proteolytic Activation of MMP-2 in the Heart
Marcia Y. Kondo, Richard Schulz

19. Matrix Metalloprotease-2 in the Development and Progression of Cardiovascular Diseases
Soumitra Roy, Tapati Chakraborti, Soni Shaikh, Animesh Chowdhury, Sajal Chakraborti

20. Role of Protease Activation in Subcellular Remodeling and Heart Failure
Naranjan S. Dhalla, Vijayan Elimban, Davinder S. Jassal

21. Proteases as Potential Targets in Left Ventricular Remodeling After Myocardial Infarction
Bodh I. Jugdutt

22. MMPs in Cardiovascular Diseases: Emerging Pharmacological Targets
Aastha Chhabra, Shrey Kohli, Vibha Rani

23. Proteases as Clinical Markers of Adverse Remodeling for Heart Failure in the Aging Population
Bodh I. Jugdutt

Keywords: Life Sciences, Proteomics, Cell Physiology, Receptors, Cancer Research, Neurosciences, Biomedicine general