Nuclear Signaling Pathways and Targeting Transcription in Cancer

Part I. Gene Regulation and Cancer

1. Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression
Weiwen Long, Bert W. O’Malley

2. Role of Alteration/Deficiency in Activation (ADA) Complex in Cell Cycle, Genomic Instability and Cancer
Shakur Mohibi, Shashank Srivastava, Hamid Band, Vimla Band

3. RUNX2 Transcriptional Regulation in Development and Disease
Jessica L. Brusgard, Antonino Passaniti

4. Epigenetic Mechanisms of Cancer Metastasis
Jing Liang, Yongfeng Shang

Part II. Signaling Pathway and Cancer

5. Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications
Elspeth M. Beauchamp, Ruth Serrano, Leonidas C. Platanias

6. Nuclear Factors Linking Cancer and Inflammation
Kunzang Chosdol, Mohita Bhagat, Bhawana Dikshit, Evanka Madan, Parthaprasad Chattopadhyay, Subrata Sinha

7. Regulation of the Jak/STATs Pathways by Histone Deacetylases
David M. Woods, Maritza Lienlaf-Moreno, Eduardo Sotomayor, Edward Seto, Alejandro Villagra

8. Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers
Longfei Huo, Jennifer L. Hsu, Mien-Chie Hung

9. Nucleolar Signaling Determines Cell Fate: The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis
Yong Liu, Yanping Zhang

10. Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment
Chenguang Wang, Jun-Yuan Ji, Lifeng Tian, Richard G. Pestell

Part III. Protein Domains and Cancer Therapeutics

11. Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology
Susanne Müller, Hannah Lingard, Stefan Knapp

12. Domain Specific Targeting of Cancer
Pratik Chandrani, Amit Dutt

Part IV. Targeted Cancer Therapy

13. The Potential of Targeting Splicing for Cancer Therapy
Ana Rita Grosso, Maria Carmo-Fonseca

14. Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies
Angela Alexander, Khandan Keyomarsi

15. Histone Demethylases in Prostate Cancer
Ling-Yu Wang, Wenchang Guo, Kevin Kim, Mamata Pochampalli, Chiu-Lien Hung, Yoshihiro Izumiya, Hsing-Jien Kung

16. Therapeutic Significance of Chromatin Remodeling Complexes in Cancer
Da-Qiang Li, Rakesh Kumar

Keywords: Biomedicine, Cancer Research, Pharmacology/Toxicology