Sequential Experimentation in Clinical Trials

1. Introduction
Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih

2. Nonlinear Regression, Experimental Design, and Phase I Clinical Trials
Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih

3. Sequential Testing Theory and Stochastic Optimization Over Time
Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih

4. Group Sequential Design of Phase II and III Trials
Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih

5. Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health
Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih

6. Time-Sequential Design of Clinical Trials with Failure-Time Endpoints
Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih

7. Confidence Intervals and p-Values
Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih

8. Adaptive Design of Confirmatory Trials
Jay Bartroff, Tze Leung Lai, Mei-Chiung Shih

Keywords: Statistics, Statistics for Life Sciences, Medicine, Health Sciences, Statistics, general, Statistical Theory and Methods