Annunziato, Lucio

Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications

Annunziato, Lucio - Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications, ebook


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Table of contents

Part I. Historical Perspective

1. Livin’ with NCX and Lovin’ It: A 45 Year Romance
Mordecai P. Blaustein

2. 20 Years from NCX Purification and Cloning: Milestones
Debora A. Nicoll, Michela Ottolia, Joshua I. Goldhaber, Kenneth D. Philipson

Part II. Structural and Functional Aspects of NCX

3. Ca2+ Regulation in the Na+/Ca2+ Exchanger Features a Dual Electrostatic Switch Mechanism
Mark Hilge

4. Molecular Determinants of Allosteric Regulation in NCX Proteins
Moshe Giladi, Daniel Khananshvili

5. NCX1: Mechanism of Transport
Michela Ottolia, Kenneth D. Philipson

6. Structural Studies of the Ca2+ Regulatory Domain of Drosophila Na+/Ca2+ Exchanger CALX
Lei Zheng, Mousheng Wu, Shuilong Tong

7. Interplay of Ca2+ and Mg2+ in Sodium-Calcium Exchanger and in Other Ca2+-Binding Proteins: Magnesium, Watchdog That Blocks Each Turn if Able
Dmitri O. Levitsky, Masayuki Takahashi

Part III. Structural and Functional Aspects of NCKX

8. Functional and Structural Properties of the NCKX2 Na+-Ca2+/K+ Exchanger: A Comparison with the NCX1 Na+/Ca2+ Exchanger
Haider F. Altimimi, Robert T. Szerencsei, Paul P. M. Schnetkamp

9. NCKX5, a Natural Regulator of Human Skin Colour Variation, Regulates the Expression of Key Pigment Genes MC1R and Alpha-MSH and Alters Cholesterol Homeostasis in Normal Human Melanocytes
Stephen Wilson, Rebecca S. Ginger, Tony Dadd, David Gunn, Fei-Ling Lim, Magdalena Sawicka, Melanie Sandel, Paul P. M. Schnetkamp, Martin R. Green

10. Expression and Regulation of Sodium/Calcium Exchangers, NCX and NCKX, in Reproductive Tissues: Do They Play a Critical Role in Calcium Transport for Reproduction and Development?
Hyun Yang, Kyung-Chul Choi, Eui-Man Jung, Beum-Soo An, Sang-Hwan Hyun, Eui-Bae Jeung

Part IV. Genetic and Epigenetic Regulation

11. Transcriptional Pathways and Potential Therapeutic Targets in the Regulation of Ncx1 Expression in Cardiac Hypertrophy and Failure
Donald R. Menick, Mona S. Li, Olga Chernysh, Ludivine Renaud, Denise Kimbrough, Harinath Kasiganesan, Santhosh K. Mani

12. Transcriptional Regulation of ncx1 Gene in the Brain
Valeria Valsecchi, Giuseppe Pignataro, Rossana Sirabella, Carmela Matrone, Francesca Boscia, Antonella Scorziello, Maria Josè Sisalli, Elga Esposito, Nicola Zambrano, Mauro Cataldi, Gianfranco Renzo, Lucio Annunziato

Part V. Regulatory Mechanisms of NCX

13. Metabolic Regulation of the Squid Nerve Na+/Ca2+ Exchanger: Recent Developments
Luis Beaugé, Reinaldo DiPolo, Mariana Bollo, Alexandra Cousido, Graciela Berberián, Alberto Podjarny

14. Regulation of Sodium-Calcium Exchanger Activity by Creatine Kinase
Ya-Chi Yang, Lung-Sen Kao

15. Coordinated Regulation of Cardiac Na+/Ca2+ Exchanger and Na+-K+-ATPase by Phospholemman (FXYD1)
Joseph Y. Cheung, Xue-Qian Zhang, Jianliang Song, Erhe Gao, Tung O. Chan, Joseph E. Rabinowitz, Walter J. Koch, Arthur M. Feldman, JuFang Wang

Part VI. Subcellular Localization and Function of NCX in Ca-Storing Organelles and Mitochondria

16. Mitochondria Na+-Ca2+ Exchange in Cardiomyocytes and Lymphocytes
Bongju Kim, Ayako Takeuchi, Orie Koga, Masaki Hikida, Satoshi Matsuoka

17. New Insights in Mitochondrial Calcium Handling by Sodium/Calcium Exchanger
Antonella Scorziello, Claudia Savoia, Agnese Secondo, Francesca Boscia, Maria Josè Sisalli, Alba Esposito, Annalisa Carlucci, Pasquale Molinaro, Luca Lignitto, Gianfranco Renzo, Antonio Feliciello, Lucio Annunziato

Part VII. NCX in Neurodegenerative Diseases

18. Genetically Modified Mice as a Strategy to Unravel the Role Played by the Na+/Ca2+ Exchanger in Brain Ischemia and in Spatial Learning and Memory Deficits
Pasquale Molinaro, Mauro Cataldi, Ornella Cuomo, Davide Viggiano, Giuseppe Pignataro, Rossana Sirabella, Agnese Secondo, Francesca Boscia, Anna Pannaccione, Antonella Scorziello, Sophie Sokolow, André Herchuelz, Gianfranco Renzo, Lucio Annunziato

19. NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning
Giuseppe Pignataro, Ornella Cuomo, Antonio Vinciguerra, Rossana Sirabella, Elga Esposito, Francesca Boscia, Gianfranco Renzo, Lucio Annunziato

20. The Role of the Mitochondrial NCX in the Mechanism of Neurodegeneration in Parkinson’s Disease
Alison Wood-Kaczmar, Emma Deas, Nicholas W. Wood, Andrey Y. Abramov

21. The Contribution of the Sodium-Calcium Exchanger (NCX) and Plasma Membrane Ca2+ ATPase (PMCA) to Cerebellar Synapse Function
Chris J. Roome, Ruth M. Empson

Part VIII. Emerging Role of NCX Activity in Immune and Glial Cells

22. Sodium-Calcium Exchanger Modulates the L-Glutamate Cai
2+ Signalling in Type-1 Cerebellar Astrocytes
Héctor Rojas, Claudia Colina, Magaly Ramos, Gustavo Benaim, Erica Jaffe, Carlo Caputo, Reinaldo Polo

23. Immunosuppressive Drugs, Immunophilins, and Functional Expression of NCX Isoforms
Hannah Rahamimoff, Benayahu Elbaz, Michael Valitsky, Mahdi Khatib, Marina Eskin-Schwartz, Daniela Elmaz

24. Calcium Influx Through Reversed NCX Controls Migration of Microglia
Mami Noda, Masataka Ifuku, Yuki Mori, Alexei Verkhratsky

25. Sodium Fluxes and Astroglial Function
Alexei Verkhratsky, Mami Noda, Vladimir Parpura, Sergei Kirischuk

26. New Roles of NCX in Glial Cells: Activation of Microglia in Ischemia and Differentiation of Oligodendrocytes
Francesca Boscia, Carla D’Avanzo, Anna Pannaccione, Agnese Secondo, Antonella Casamassa, Luigi Formisano, Natascia Guida, Antonella Scorziello, Gianfranco Renzo, Lucio Annunziato

27. Human Macrophages and Monocytes Express Functional Na+/Ca2+ Exchangers 1 and 3
Rosaria I. Staiano, Francescopaolo Granata, Agnese Secondo, Angelica Petraroli, Stefania Loffredo, Lucio Annunziato, Massimo Triggiani, Gianni Marone

Part IX. NCX in the Heart and Vascular Smooth Muscle

28. New Insights into the Contribution of Arterial NCX to the Regulation of Myogenic Tone and Blood Pressure
Jin Zhang

29. Toward an Understanding of the Complete NCX1 Lifetime in the Cardiac Sarcolemma
Donald W. Hilgemann, Mei-Jung Lin, Michael Fine, Gary Frazier, Hao-Ran Wang

Part X. NCX Role in Hypertension, Heart Failure, Ischemia-Reperfusion, Arrhythmias and Diabetes

30. Cardiac Sodium-Calcium Exchange and Efficient Excitation-Contraction Coupling: Implications for Heart Disease
Joshua I. Goldhaber, Kenneth D. Philipson

31. Cross Talk Between Plasma Membrane Na+/Ca2+ Exchanger-1 and TRPC/Orai-Containing Channels: Key Players in Arterial Hypertension
Maria V. Pulina, A. Zulian, Sergey G. Baryshnikov, Cristina I. Linde, Eiji Karashima, John M. Hamlyn, Patrizia Ferrari, Mordecai P. Blaustein, Vera A. Golovina

32. T-Tubule Remodelling and Ryanodine Receptor Organization Modulate Sodium-Calcium Exchange
Karin R. Sipido, Károly Acsai, Gudrun Antoons, Virginie Bito, Niall Macquaide

33. Na+/Ca2+ Exchange and the Plasma Membrane Ca2+-ATPase in β-Cell Function and Diabetes
André Herchuelz, Evrard Nguidjoe, Lin Jiang, Nathalie Pachera

Part XI. NCX Partners in Ionic Homeostasis: ASIC, NMDA, NHE and TRPC

34. The Na+/H+ Exchanger NHE5 Is Sorted to Discrete Intracellular Vesicles in the Central and Peripheral Nervous Systems
Viktoria Lukashova, Tushare Jinadasa, Alina Ilie, David Verbich, Ellis Cooper, John Orlowski

35. The Role of Na+/H+ Exchanger Isoform 1 in Inflammatory Responses: Maintaining H+ Homeostasis of Immune Cells
Yejie Shi, Dong Kim, Marie Caldwell, Dandan Sun

36. Acid-Sensing Ion Channels in Pathological Conditions
Xiang-Ping Chu, Zhi-Gang Xiong

37. Nonselective Cation Channels and Links to Hippocampal Ischemia, Aging, and Dementia
John F. MacDonald, Jillian C. Belrose, Yu-Feng Xie, Michael F. Jackson

38. Erratum To: Chapter 17 New Insights in Mitochondrial Calcium Handling by Sodium/Calcium Exchanger
Antonella Scorziello, Claudia Savoia, Agnese Secondo, Francesca Boscia, Maria Josè Sisalli, Alba Esposito, Annalisa Carlucci, Pasquale Molinaro, Luca Lignitto, Gianfranco Renzo, Antonio Feliciello, Lucio Annunziato

Keywords: Biomedicine, Neurosciences, Immunology, Cardiology, Endocrinology

Publication year
Advances in Experimental Medicine and Biology
Page amount
25 pages
Medicine, Health Care, Mode

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