Human Fetal Tissue Transplantation

Part I. The Ideas Behind This Book

1. Alternatives of Human Organ/Tissue Transplantation
Niranjan Bhattacharya, Phillip Stubblefield

2. Fetomaternal Cell Trafficking: A Window into the Long-Term Health Effects of Treating Disease with Fetal Cell/Tissue Transplants?
Niranjan Bhattacharya, Phillip Stubblefield

Part II. Basic Science and the Unique Aspect of Fetal Growth and Maturation

3. Embryology of Fetal Tissue
Peter Hollands

4. Three-Dimensional Culture of Fetal Mouse, Rat, and Porcine Hepatocytes
Yasuyuki Sakai, Jinlan Jiang, Sanshiro Hanada, Hongyug Huang, Takeshi Katsuda, Nobuhiko Kojima, Takumi Teratani, Atsushi Miyajima, Takahiro Ochiya

5. Response of Fetal and Adult Cells to Growth Factors
Harris Pratsinis, Andreas A. Armatas†, Dimitris Kletsas

6. Accommodation and the Fetus
Ines Silva, Cody A. Koch, Raymond J. Lynch, Jeffrey L. Platt

7. Wharton’s Jelly-Derived Mesenchymal Stromal Cells as Immunoregulatory Cells
M. L. Weiss, Yelica López, K. R. McIntosh

8. Pluripotent Stem Cells of the Mammalian Early Embryo
Maria P. Miguel, Jon Schoorlemmer, Ignacio Garcia-Tuñón

9. Stem Cells in Fetal Tissue (The Kidney as a Model)
Oren Pleniceanu, Benjamin Dekel

10. Potential Therapeutic Applications of Placental-Derived Stem Cells to Combat Tissue Inflammation and Fibrosis
Yuben Moodley, Ursula Manuelpillai

Part III. Fetal Cell Transplant Experiments in Animal and Human Systems

11. Experiences with In Utero Transplantation of Mesenchymal Stem Cells
Carolyn Troeger, Irina Perahud, Eva Visca, Wolfgang Holzgreve

12. In Utero Hematopoietic Stem Cell Transplantation for Congenital Disorders
Amar Nijagal, Tippi C. MacKenzie

13. Tissue and Progenitor Cell Transplantation for the Management of Pituitary Disorders: From Harvey Cushing to the Next Frontier
Courtney Pendleton, Alfredo Quinones-Hinojosa

14. Fetal Cell Therapy and Tissue Engineering for Musculoskeletal Tissues
Nathalie Hirt-Burri, Lee Ann Applegate

15. Cell Therapy for Parkinson’s Disease
Yasushi Kondo, Tsuyoshi Okuno, Sayaka Asari, Shin-ichi Muramatsu

16. Transplantation of Human Fetal Liver Cells into Children or Human Fetuses
Jean-Louis Touraine

17. Fetal Liver Cell Transplantation
Suchitra Sumitran-Holgersson, Meghnad Joshi, Michael Olausson

18. Human Pancreatic Progenitors: Implications for Clinical Transplantation in Diabetes
Mugdha V. Joglekar, Anandwardhan A. Hardikar

19. Amniotic Fluid Cell Therapy to Relieve Disc-Related Low Back Pain and Its Efficacy Comparison with Long-Acting Steroid Injection
Niranjan Bhattacharya

20. Human Neural Stem Cell Transplants in Neurological Disorders: Current Trends and Future Options
Abhijit Chaudhuri, Niranjan Bhattacharya

21. Umbilical Cord Stem Cells for Pancreatic Regenerative Medicine
Hélène Roy, Nicolas Forraz, Marcin Jurga, Colin P. McGuckin

22. Maturation of the Human Fetal Pancreas: A Lesson for Embryonic Stem Cell Differentiation as a Therapy for Diabetes
Bernard E. Tuch, Steven Y. Gao, Jennifer C. Y. Wong, Justin G. Lees

Part IV. Fetal Tissue Transplant Experiments in Animal and Human Systems

23. Fetal Neural Tissue Transplantation for Spinal Cord Injury Repair
Sankar Venkatachalam

24. Fetal Lung Tissue Transplant at a Heterotopic Site in Common Chronic Inflammatory Diseases of the Airways: A Study of 11 Cases
Niranjan Bhattacharya

25. Treatment by Human Fetal Neuronal Tissue Transplant at a Heterotopic Site in the Axilla in Case of Motor Neuron Disease: A Report of Two Cases
Niranjan Bhattacharya

26. Adjuvant Role of Human Heterotopic Fetal Kidney Tissue Transplant in Reversing the Visible Parameters of Chronic Renal Diseases: A Preliminary Report of 9 Cases
Niranjan Bhattacharya

27. Treatment by Human Fetal Neuronal Tissue Transplant from Brain and Spinal Cord at Heterotopic Site in Axilla in Case of Posttraumatic Quadriplegia: A Report of Two Cases
Niranjan Bhattacharya

28. Fetal Liver Tissue Transplant in Alcoholic Fatty Degeneration of the Liver: A Study of 13 Cases
Niranjan Bhattacharya

29. Human Heterotopic Fetal Cardiac Tissue Transplant in Patients with Varying Degrees of Cardiomyopathy with Ischemic Heart Disease and Diabetes Mellitus: A Report of 7 Cases
Niranjan Bhattacharya, M. K. Chettri, M. K. Chettri

30. A Study and Follow-Up (1999–2012) of Fetal Midbrain Tissue Transplant (Iatrogenic Chimera) at a Heterotopic Site in Axilla as a Treatment Support in Cases of Adult Idiopathic Parkinsonism Patients
Niranjan Bhattacharya, Abhijit Chaudhuri

31. Growing Organs for Transplantation from Embryonic Precursor Tissues
Dalit Yutzis-Tchorsh, Yair Reisner

Part V. Fetal Organ Transplant Experiments in Animal and Human Systems

32. Fetal Thymus Transplantation in DiGeorge Syndrome
Jean-Louis Touraine

33. Clinical Improvement After First-Trimester Fetal Whole Pancreas Transplant at a Heterotopic Site in Uncontrolled Diabetes with Varying Degrees of Skin Ulceration of the Leg and Emaciation
Niranjan Bhattacharya

34. Experience with Human Fetal Thymus Transplantation In a Heterotopic Site in Patients with Advanced Lymphoma and Leukopenia
Niranjan Bhattacharya

35. Human Fetal Adrenal Transplant at Heterotopic Site as an Adjuvant for Treatment of Excruciating Pain in Cases of Arthritides
Niranjan Bhattacharya

Part VI. Biobanking

36. Biobanking and Cryopreservation of Obstetrical Cell Sources for Cardiovascular Tissue Engineering: Implications for Future Therapies
Steffen M. Zeisberger, Benedikt Weber, Simon P. Hoerstrup

Part VII. Ethics of Fetal Tissue Transplant

37. Of Bioethics, Stem Cells, and Tissue Transplants
Sanjukta Banerji Bhattacharya, Phillip Stubblefield

Keywords: Medicine & Public Health, Hematology, Pathology