Diffuse Low-Grade Gliomas in Adults

1. Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Diffuse Low-Grade Gliomas
Hugues Duffau

Part I. Epidemiology and Classification

2. Epidemiology of Diffuse Low-Grade Gliomas
Luc Bauchet

3. Histological Classification
Valérie Rigau

4. Is Gliomatosis Cerebri a Diffuse Low-Grade Glioma?
Catherine Godfraind

5. Contribution of Molecular Biology to the Classification of Low-Grade Diffuse Glioma
Hiroko Ohgaki

Part II. Basic Science and Experimental Research in DLGG

6. Cellular Origin of Grade II Gliomas
Pierre-Olivier Guichet, Jean-Philippe Hugnot

7. Deciphering the Molecular and Cellular Basis for Dissemination of Diffuse Low-Grade Gliomas
Zahra Hassani, Jean-Philippe Hugnot

8. The Molecular Biology of Diffuse Low-Grade Gliomas
Nicholas F. Marko, Robert J. Weil

9. Proteomic Studies in Low-Grade Gliomas: What Have They Informed About Pathophysiology?
A. M. J. Gerth, R. F. Deighton, J. McCulloch, Ian R. Whittle

10. Human Low-Grade Glioma Cultures
Daniela Cesselli, Antonio Paolo Beltrami, Anja Pucer, Evgenia Bourkoula, Tamara Ius, Marco Vindigni, Miran Skrap, Carlo Alberto Beltrami

11. Animal Models for Low-Grade Gliomas
Rolf Bjerkvig, Sébastien Bougnaud, Simone P. Niclou

Part III. Clinical Aspects and Diagnostic Imaging

12. Clinical Presentation in Diffuse Low-Grade Gliomas
Juan Torres-Reveron, Joseph M. Piepmeier, Kevin P. Becker

13. Epilepsy in Diffuse Low-Grade Gliomas
Anja Smits

14. Quality of Life in Low-Grade Gliomas
Martin J. B. Taphoorn

15. Metabolic-Oncological MR Imaging of Diffuse Low-Grade Glioma: A Dynamic Approach
Rémy Guillevin

16. Positron Emission Tomography in Diffuse Low-Grade Gliomas
Karl-Josef Langen, Frank Willi Floeth, Michael Sabel, Norbert Galldiks

17. Dynamics of DLGG and Clinical Implications
Emmanuel Mandonnet

Part IV. Natural History and Spontaneous Prognostic Factors

18. Natural History and Spontaneous Prognostic Factors
Roberta Rudà, Luca Bertero, Riccardo Soffietti

Part V. Functional Assessment and Interaction with the Brain

19. Language and Other Cognitive Evaluations
Sylvie Moritz-Gasser, Guillaume Herbet

20. Functional MR and Diffusion MR Imaging in Diffuse Low-Grade Gliomas
Alberto Bizzi

21. Magnetoencephalography, Functional Connectivity, and Neural Network Topology in Diffuse Low-Grade Gliomas
Jan J. Heimans, Jaap C. Reijneveld, Cornelis J. Stam

22. Interactions Between Diffuse Low-Grade Glioma (DLGG) and Brain Plasticity
Hugues Duffau

Part VI. New Insights into the Therapeutic Strategies for DLGG

23. Surgery for Diffuse Low-Grade Gliomas (DLGG) Oncological Considerations
Hugues Duffau

24. Surgery for Diffuse Low-Grade Gliomas (DLGG) Functional Considerations
Hugues Duffau

25. Chemotherapy for Diffuse Low-Grade Gliomas
Luc Taillandier

26. Radiation Therapy for the Treatment of Diffuse Low-Grade Gliomas
Stephanie E. Combs

27. New Individualized Strategies in DLGG
Hugues Duffau, Luc Taillandier

Part VII. Prospects

28. Biomathematical Modeling of DLGG Behavior
Emmanuel Mandonnet

29. Toward the Definition of New Endpoints
Emmanuel Mandonnet, Luc Bauchet, Luc Taillandier, Hugues Duffau

30. Functional Rehabilitation in Patients with Diffuse Low-Grade Glioma (DLGG)
Guillaume Herbet, Sylvie Moritz-Gasser

31. Early Detection and Management of Incidental Diffuse Low-Grade Gliomas (IDLGG): Toward a “Prophylactic Oncological Neurosurgery”
Hugues Duffau

32. The Origins of Diffuse Low-Grade Gliomas (DLGGs): “Functional Theory” Versus “Molecular Theory”
Catherine Gozé, Luc Taillandier, Valérie Rigau, Luc Bauchet, Hugues Duffau

Keywords: Medicine & Public Health, Oncology, Neurology, Neuroradiology