Folding for the Synapse

1. Folding for the Synapse
Andreas Wyttenbach, Vincent O’Connor

2. Protein Aggregation: Opposing Effects of Chaperones and Crowding
R. John Ellis

3. Molecular Chaperones as Facilitators of Protein Degradation
Jörg Höhfeld, Nikolaus Dick, Verena Arndt

4. The Small Heat-Shock Proteins: Cellular Functions and Mutations Causing Neurodegeneration
C. d’Ydewalle, J. Krishnan, V. Timmerman, L. Bosch

5. Keeping it Together. Axonal Transport to the Synapse and the Effects of Molecular Chaperones in Health and Disease
Christopher Sinadinos, Amrit Mudher

6. Mechanisms of Neuronal Mitochondrial Transport
F. Anne Stephenson, Kieran Brickley

7. Molecular Chaperones in the Mammalian Brain: Regional Distribution, Cellular Compartmentalization and Synaptic Interactions
Andreas Wyttenbach, Shmma Quraishe, Joanne Bailey, Vincent O’Connor

8. Cysteine-String Protein’s Role at Synapses
Konrad E. Zinsmaier, Mays Imad

9. The Role of Protein SUMOylation in Neuronal Function
Kevin A. Wilkinson, Jeremy M. Henley

10. The Ubiquitin–Proteasome System in Synapses
Suzanne Tydlacka, Shi-Hua Li, Xiao-Jiang Li

11. VAPB Aggregates and Neurodegeneration
P. Skehel

12. Synaptic Dysfunction in Huntington’s Disease
Dervila Glynn, A. Jennifer Morton

13. Synaptic Dysfunction in Parkinson’s Disease: From Protein Misfolding to Functional Alterations
Tiago Fleming Outeiro, Luísa Vaqueiro Lopes

14. Synapses and Alzheimers’s Disease: Effect of Immunotherapy?
Nathan C. Denham, James A. R. Nicoll, Delphine Boche

15. Prion Protein Misfolding at the Synapse
Zuzana Šišková, V. Hugh Perry, Ayodeji A. Asuni

Keywords: Biomedicine, Neurosciences, Molecular Medicine, Neurobiology, Cell Biology, Biochemistry, general